Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics

At the cross-point of connexins, calcium, and ATP: blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries

(2016) Mélissa Bol et al.   CARDIOVASCULAR RESEARCH

Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease

(2016) C Yi et al.   CELL DEATH AND DIFFERENTIATION

Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism

(2016) Rosario Gajardo-Gómez et al.   GLIA

Connexin43 hemichannels mediate secondary cellular damage spread from the trauma zone to distal zones in astrocyte monolayers

(2015) Maximiliano Rovegno et al.   GLIA

Dual pathways mediate β-amyloid stimulated glutathione release from astrocytes

(2015) Bing Ye et al.   GLIA

Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

(2015) Verónica Abudara et al.   GLIA

Isoform-specific phosphorylation-dependent regulation of connexin hemichannels

(2015) Jette Skov Alstrøm et al.   JOURNAL OF NEUROPHYSIOLOGY

Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder

(2015) Jonathan M. Beckel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Amyloid β peptide (25–35) in picomolar concentrations modulates the function of glycine receptors in rat hippocampal pyramidal neurons through interaction with extracellular site(s)

(2014) J.V. Bukanova et al.   BRAIN RESEARCH

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc

(2014) Esperanza Agullo-Pascual et al.   CARDIOVASCULAR RESEARCH

Role of Connexins and Pannexins in Ischemic Stroke

(2014) J.A. Orellana et al.   CURRENT MEDICINAL CHEMISTRY

Hunting for connexin hemichannels

(2014) Juan C. Sáez et al.   FEBS LETTERS

Connexin hemichannel and pannexin channel electrophysiology: How do they differ?

(2014) Dakshesh Patel et al.   FEBS LETTERS

Distinct permeation profiles of the connexin 30 and 43 hemichannels

(2014) Daniel Bloch Hansen et al.   FEBS LETTERS

Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels

(2014) Daniel Bloch Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astroglial Connexin43 Hemichannels Tune Basal Excitatory Synaptic Transmission

(2014) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Connexin43 hemichannels mediate small molecule exchange between chondrocytes and matrix in biomechanically-stimulated temporomandibular joint cartilage

(2014) J. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Permeation, regulation and control of expression of TRP channels by trace metal ions

(2014) Alexandre Bouron et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ultrafine carbon black induces glutamate and ATP release by activating connexin and pannexin hemichannels in cultured astrocytes

(2014) Hongying Wei et al.   TOXICOLOGY

Opening of pannexin- and connexin-based channels increases the excitability of nodose ganglion sensory neurons

(2014) Mauricio A. Retamal et al.   Frontiers in Cellular Neuroscience

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes

(2014) Verónica Abudara et al.   Frontiers in Cellular Neuroscience

Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet

(2014) Juan A. Orellana et al.   Frontiers in Cellular Neuroscience

Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling

(2013) Helene M. Langevin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism

(2013) Juan Andres Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Connexin47 Protein Phosphorylation and Stability in Oligodendrocytes Depend on Expression of Connexin43 Protein in Astrocytes

(2013) D. May et al.   JOURNAL OF NEUROSCIENCE

Regulation of connexin hemichannel activity by membrane potential and the extracellular calcium in health and disease

(2013) Ilaria Fasciani et al.   NEUROPHARMACOLOGY

Antibodies targeting extracellular domain of connexins for studies of hemichannels

(2013) Manuel A. Riquelme et al.   NEUROPHARMACOLOGY

Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening

(2013) Nan Wang et al.   NEUROPHARMACOLOGY

Flufenamic acid as an ion channel modulator

(2013) Romain Guinamard et al.   PHARMACOLOGY & THERAPEUTICS

Connexin43 Hemichannel-Mediated Regulation of Connexin43

(2013) Kai Li et al.   PLoS One

Cyclic nucleotide permeability through unopposed connexin hemichannels

(2013) Virginijus Valiunas   Frontiers in Pharmacology

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles

(2013) Christian Giaume et al.   Frontiers in Pharmacology

Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury

(2012) Michael J. Chen et al.   GLIA

Manipulating Connexin Communication Channels: Use of Peptidomimetics and the Translational Outputs

(2012) W. Howard Evans et al.   JOURNAL OF MEMBRANE BIOLOGY

Critical Role of Connexin 43 in Secondary Expansion of Traumatic Spinal Cord Injury

(2012) C. Huang et al.   JOURNAL OF NEUROSCIENCE

Putative TRP channel antagonists, SKF 96365, flufenamic acid and 2-APB, are non-competitive antagonists at recombinant human α1β2γ2 GABAA receptors

(2012) M.G. Rae et al.   NEUROCHEMISTRY INTERNATIONAL

Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels

(2012) T. Desplantez et al.   PHARMACOLOGICAL RESEARCH

Electrophysiology of Single and Aggregate Cx43 Hemichannels

(2012) Cole Brokamp et al.   PLoS One

Mechanical stress-activated integrin  5 1 induces opening of connexin 43 hemichannels

(2012) N. Batra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species

(2011) Juan A. Orellana et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice

(2011) John A. Jansen et al.   HEART RHYTHM

Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia

(2011) Lucia Seminario-Vidal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

(2011) Juan A. Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes

(2010) Meera Sridharan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Carbenoxolone inhibits volume-regulated anion conductance in cultured rat cortical astroglia

(2010) Valentina Benfenati et al.   Channels

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity

(2010) Raf Ponsaerts et al.   FASEB JOURNAL

Role of astroglial connexin30 in hippocampal gap junction coupling

(2010) Dominic Gosejacob et al.   GLIA

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels

(2010) J. M. Garre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system

(2009) Christian Giaume et al.   BRAIN RESEARCH REVIEWS

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

(2009) Elke De Vuyst et al.   CELL CALCIUM

Differential water permeability and regulation of three aquaporin 4 isoforms

(2009) Robert A. Fenton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Direct Actions of Carbenoxolone on Synaptic Transmission and Neuronal Membrane Properties

(2009) Kenneth R. Tovar et al.   JOURNAL OF NEUROPHYSIOLOGY

Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"

(2009) R. Iglesias et al.   JOURNAL OF NEUROSCIENCE

Structure of the connexin 26 gap junction channel at 3.5 Å resolution

(2009) Shoji Maeda et al.   NATURE

Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs

(2009) Hongzhen Hu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: Animal and human studies

(2009) Grzegorz R. Juszczak et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

(2008) R. Iglesias et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP

(2008) Feng Qiu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Similar Transcriptomic Alterations in Cx43 Knockdown and Knockout Astrocytes

(2008) Dumitru A. Iacobas et al.   CELL COMMUNICATION AND ADHESION

Currently Used Methods for Identification and Characterization of Hemichannels

(2008) Kurt A. Schalper et al.   CELL COMMUNICATION AND ADHESION

Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary culture

(2008) Hong-Tao Liu et al.   CELL RESEARCH

Extracellular-loop peptide antibodies reveal a predominant hemichannel organization of connexins in polarized intestinal cells

(2008) Caroline Clair et al.   EXPERIMENTAL CELL RESEARCH

Pharmacological “cross-inhibition” of connexin hemichannels and swelling activated anion channels

(2008) Zu-Cheng Ye et al.   GLIA

Stimulated Efflux of Amino Acids and Glutathione from Cultured Hippocampal Slices by Omission of Extracellular Calcium

(2008) Malin H. Stridh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptation of Connexin 43-Hemichannel Prostaglandin Release to Mechanical Loading

(2008) Arlene J. Siller-Jackson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 Hemichannels Are Permeable to ATP

(2008) J. Kang et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Characterization of Pannexin-1 Currents Expressed in Mammalian Cells

(2008) W. Ma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Connexins, pannexins, innexins: novel roles of “hemi-channels”

(2008) Eliana Scemes et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear

(2008) F. Anselmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA