Endoplasmic Reticulum Stress: Relevance and Therapeutics in Central Nervous System Diseases

Calcium-dependent protein folding in amyotrophic lateral sclerosis

(2013) Tino Prell et al.   CELL CALCIUM

Neuronal ER Stress Impedes Myeloid-Cell-Induced Vascular Regeneration through IRE1α Degradation of Netrin-1

(2013) François Binet et al.   Cell Metabolism

Polymorphism −116C/G of Human X-box-Binding Protein 1 Promoter is Associated with Risk of Alzheimer's Disease

(2013) Sheng-Yuan Liu et al.   CNS Neuroscience & Therapeutics

Tenuigenin Attenuatesα-Synuclein-Induced Cytotoxicity by Down-Regulating Polo-Like Kinase 3

(2013) Jin-Xia Zhou et al.   CNS Neuroscience & Therapeutics

Kir6.1 Knockdown Aggravates Cerebral Ischemia/Reperfusion-Induced Neural Injury in Mice

(2013) Yin-Feng Dong et al.   CNS Neuroscience & Therapeutics

Endoplasmic Reticulum Stress Plays a Key Role in the Pathogenesis of Diabetic Peripheral Neuropathy

(2013) S. Lupachyk et al.   DIABETES

Role of Endoplasmic Reticulum Stress in Diabetic Neuropathy

(2013) N. E. Cameron   DIABETES

Mapping the crossroads of immune activation and cellular stress response pathways

(2013) Nuno Cláudio et al.   EMBO JOURNAL

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

(2013) Timothy M Miller et al.   LANCET NEUROLOGY

Regulation of Autophagy and Ubiquitinated Protein Accumulation by bFGF Promotes Functional Recovery and Neural Protection in a Rat Model of Spinal Cord Injury

(2013) Hong-Yu Zhang et al.   MOLECULAR NEUROBIOLOGY

Viral Delivery of Antioxidant Genes as a Therapeutic Strategy in Experimental Models of Amyotrophic Lateral Sclerosis

(2013) Aikaterini Nanou et al.   MOLECULAR THERAPY

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Delayed neurological deterioration after subarachnoid haemorrhage

(2013) R. Loch Macdonald   Nature Reviews Neurology

Restoring endoplasmic reticulum homeostasis improves functional recovery after spinal cord injury

(2013) Sujata Saraswat Ohri et al.   NEUROBIOLOGY OF DISEASE

Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders

(2013) Liang Qiang et al.   NEURON

Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis

(2013) J. C. Dodge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From basics to clinical: A comprehensive review on spinal cord injury

(2013) Nuno A. Silva et al.   PROGRESS IN NEUROBIOLOGY

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

An ERcentric view of Parkinson's disease

(2013) Gabriela Mercado et al.   TRENDS IN MOLECULAR MEDICINE

The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress

(2012) Richard Jäger et al.   BIOLOGY OF THE CELL

Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity

(2012) Christel Dentel et al.   BRAIN

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Exogenous Basic Fibroblast Growth Factor Inhibits ER Stress-Induced Apoptosis and Improves Recovery from Spinal Cord Injury

(2012) Hong-Yu Zhang et al.   CNS Neuroscience & Therapeutics

Therapeutic Targeting of the Endoplasmic Reticulum in Alzheimers Disease

(2012) Wayne Chadwick et al.   Current Alzheimer Research

Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes

(2012) C. Sims-Robinson et al.   DIABETOLOGIA

BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α

(2012) Diego A Rodriguez et al.   EMBO JOURNAL

Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

Inhibition of mitochondrial cytochrome c oxidase potentiates Aβ-induced ER stress and cell death in cortical neurons

(2012) Rui O. Costa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Endoplasmic Reticulum Enrollment in Alzheimer’s Disease

(2012) Ricardo J. S. Viana et al.   MOLECULAR NEUROBIOLOGY

Spinal cord trauma and the molecular point of no return

(2012) Ping K Yip et al.   Molecular Neurodegeneration

Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice

(2012) Adrian C. Lo et al.   NEUROBIOLOGY OF DISEASE

bFGF inhibits ER stress induced by ischemic oxidative injury via activation of the PI3K/Akt and ERK1/2 pathways

(2012) Zhouguang Wang et al.   TOXICOLOGY LETTERS

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

(2012) V Valenzuela et al.   Cell Death & Disease

Deletion of the Pro-Apoptotic Endoplasmic Reticulum Stress Response Effector CHOP Does Not Result in Improved Locomotor Function after Severe Contusive Spinal Cord Injury

(2011) Sujata Saraswat Ohri et al.   JOURNAL OF NEUROTRAUMA

3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP

(2011) Krishnamoorthy Srinivasan et al.   LIFE SCIENCES

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

(2011) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

ER stress response plays an important role in aggregation of α-synuclein

(2011) Peizhou Jiang et al.   Molecular Neurodegeneration

Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

(2011) Xi Chen et al.   Molecular Neurodegeneration

Augmentation of endoplasmic reticulum stress in cerebral ischemia/reperfusion injury associated with comorbid type 2 diabetes

(2011) Krishnamoorthy Srinivasan et al.   NEUROLOGICAL RESEARCH

Neuroprotective effect of mithramycin against endoplasmic reticulum stress-induced neurotoxicity in organotypic hippocampal slice cultures

(2011) Yasuhiro Kosuge et al.   NEUROPHARMACOLOGY

Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury

(2011) C. Penas et al.   NEUROSCIENCE

Silencing GADD153/CHOP Gene Expression Protects against Alzheimer's Disease-Like Pathology Induced by 27-Hydroxycholesterol in Rabbit Hippocampus

(2011) Jaya R. P. Prasanthi et al.   PLoS One

Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease

(2010) Yasuyuki Honjo et al.   BRAIN RESEARCH

Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway

(2010) Yajing Yuan et al.   BRAIN RESEARCH

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosis

(2010) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Parkinson's Disease Dementia and Potential Therapeutic Strategies

(2010) John N. Caviness et al.   CNS Neuroscience & Therapeutics

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

(2010) Jin Hwan Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Endoplasmic Reticulum Stress Sensor, ATF6α, Protects against Neurotoxin-induced Dopaminergic Neuronal Death

(2010) Naohiro Egawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson’s disease

(2010) Arianna Bellucci et al.   JOURNAL OF NEUROCHEMISTRY

Sodium 4-phenylbutyrate protects against spinal cord ischemia by inhibition of endoplasmic reticulum stress

(2010) Taketomo Mizukami et al.   JOURNAL OF VASCULAR SURGERY

Characterization of neuronal and astroglial responses to ER stress in the hippocampal CA1 area in mice following transient forebrain ischemia

(2010) Nobuhiro Osada et al.   NEUROCHEMISTRY INTERNATIONAL

Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice

(2010) Yasuhisa Oida et al.   NEUROSCIENCE LETTERS

Phenylbutyric Acid Rescues Endoplasmic Reticulum Stress-Induced Suppression of APP Proteolysis and Prevents Apoptosis in Neuronal Cells

(2010) Jesse C. Wiley et al.   PLoS One

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

Moderate exercise delays the motor performance decline in a transgenic model of ALS

(2009) Isabel Carreras et al.   BRAIN RESEARCH

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

(2009) M Wang et al.   CELL DEATH AND DIFFERENTIATION

ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis

(2009) Kohsuke Kanekura et al.   MOLECULAR NEUROBIOLOGY

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE