Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension

Interleukin-6 (IL-6) Trans Signaling Drives a STAT3-dependent Pathway That Leads to Hyperactive Transforming Growth Factor-β (TGF-β) Signaling Promoting SMAD3 Activation and Fibrosis via Gremlin Protein

(2014) Steven O'Reilly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Gremlin-1 in Patients with Loeys-Dietz Syndrome: Implications on Pathophysiology and Early Disease Detection

(2014) Jasmin Wellbrock et al.   PLoS One

Treatment with Anti–Gremlin 1 Antibody Ameliorates Chronic Hypoxia/SU5416–Induced Pulmonary Arterial Hypertension in Mice

(2013) Loredana Ciuclan et al.   AMERICAN JOURNAL OF PATHOLOGY

Gremlin-1 Identifies Fibrosis and Predicts Adverse Outcome in Patients With Heart Failure Undergoing Endomyocardial Biopsy

(2013) Karin A.L. Mueller et al.   JOURNAL OF CARDIAC FAILURE

Updated Clinical Classification of Pulmonary Hypertension

(2013) Gerald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension

(2012) Edwina Cahill et al.   CIRCULATION

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Bone Morphogenetic Protein Receptor II Is a Novel Mediator of Endothelial Nitric-oxide Synthase Activation

(2011) Archana Gangopahyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

(2010) S. Mitola et al.   BLOOD

Penetrance of pulmonary arterial hypertension is modulated by the expression of normalBMPR2allele

(2009) Rizwan Hamid et al.   HUMAN MUTATION

Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension

(2008) Christine M. Costello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Gremlin promotes vascular smooth muscle cell proliferation and migration

(2007) Thiago T. Maciel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY