Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7

Twisted Gastrulation, a BMP Antagonist, Exacerbates Podocyte Injury

(2014) Sachiko Yamada et al.   PLoS One

Treatment with Anti–Gremlin 1 Antibody Ameliorates Chronic Hypoxia/SU5416–Induced Pulmonary Arterial Hypertension in Mice

(2013) Loredana Ciuclan et al.   AMERICAN JOURNAL OF PATHOLOGY

Gremlin aggravates hyperglycemia-induced podocyte injury by a TGFβ/smad dependent signaling pathway

(2013) Guiying Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Bone Morphogenetic Protein–Inducer Tilorone Identified by High-Throughput Screening Is AntifibroticIn Vivo

(2012) Outi Leppäranta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists

(2012) Hamed Alborzinia et al.   JOURNAL OF CELL SCIENCE

Members of the DAN Family Are BMP Antagonists That Form Highly Stable Noncovalent Dimers

(2012) Chandramohan Kattamuri et al.   JOURNAL OF MOLECULAR BIOLOGY

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

(2012) Hikaru Sugimoto et al.   NATURE MEDICINE

Heparan Sulfate Proteoglycans Mediate the Angiogenic Activity of the Vascular Endothelial Growth Factor Receptor-2 Agonist Gremlin

(2011) Paola Chiodelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts

(2011) Simon P. Curran et al.   CELLULAR SIGNALLING

Bone morphogenetic protein 7: A broad-spectrum growth factor with multiple target therapeutic potency

(2011) Mariëtte R. Boon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Insulin receptor substrate 2 and FoxO3a signalling are involved in E-cadherin expression and transforming growth factor-β1-induced repression in kidney epithelial cells

(2011) Rosemarie M. Carew et al.   FEBS Journal

Activation of Bone Morphogenetic Protein 4 Signaling Leads to Glomerulosclerosis That Mimics Diabetic Nephropathy

(2011) Tatsuya Tominaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition

(2011) Yu-Lin Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Gremlin1 is required for skeletal development and postnatal skeletal homeostasis

(2011) Ernesto Canalis et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Circulating Bone Morphogenetic Protein 1-3 Isoform Increases Renal Fibrosis

(2011) L. Grgurevic et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The BMP-7–Smad1/5/8 Pathway Promotes Kidney Repair After Obstruction Induced Renal Injury

(2011) Scott R. Manson et al.   JOURNAL OF UROLOGY

Genetic Analysis Reveals an Unexpected Role of BMP7 in Initiation of Ureteric Bud Outgrowth in Mouse Embryos

(2011) Alexandre Gonçalves et al.   PLoS One

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

(2010) Christopher C. Rider et al.   BIOCHEMICAL JOURNAL

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

(2010) S. Mitola et al.   BLOOD

Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys

(2010) Jan Willem Leeuwis et al.   JOURNAL OF PATHOLOGY

In Vivo Delivery of Gremlin siRNA Plasmid Reveals Therapeutic Potential against Diabetic Nephropathy by Recovering Bone Morphogenetic Protein-7

(2010) Qingxian Zhang et al.   PLoS One

Extracellular BMP-antagonist regulation in development and disease: tied up in knots

(2010) David W. Walsh et al.   TRENDS IN CELL BIOLOGY

Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease

(2009) S. A. Roxburgh et al.   DIABETES

Bone Morphogenetic Protein-2 Antagonizes Renal Interstitial Fibrosis by Promoting Catabolism of Type I Transforming Growth Factor-β Receptors

(2008) Yu-Lin Yang et al.   ENDOCRINOLOGY

BMP-7 fails to attenuate TGF- 1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells

(2008) P. L. Dudas et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Bone Morphogenetic Protein-7 and Connective Tissue Growth Factor: Novel Targets for Treatment of Renal Fibrosis?

(2008) Tri Q. Nguyen et al.   PHARMACEUTICAL RESEARCH

BMP-7 Does Not Protect against Bleomycin-Induced Lung or Skin Fibrosis

(2008) Lynne A. Murray et al.   PLoS One

Gremlin: A Novel Mediator of Epithelial Mesenchymal Transition and Fibrosis in Chronic Allograft Nephropathy

(2008) G. Carvajal et al.   TRANSPLANTATION PROCEEDINGS

Co-regulation of Gremlin and Notch signalling in diabetic nephropathy

(2007) David W. Walsh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Focus on Molecules: Gremlin

(2007) Robert J. Wordinger et al.   EXPERIMENTAL EYE RESEARCH