Meeting report of the 8th International Conference on cGMP “cGMP: generators, effectors, and therapeutic implications” at Bamberg, Germany, from June 23 to 25, 2017

Patient-reported outcomes in the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED ejection fraction (SOCRATES-PRESERVED) study

(2017) Gerasimos Filippatos et al.   EUROPEAN JOURNAL OF HEART FAILURE

RESPITE: switching to riociguat in pulmonary arterial hypertension patients with inadequate response to phosphodiesterase-5 inhibitors

(2017) Marius M. Hoeper et al.   EUROPEAN RESPIRATORY JOURNAL

Sacubitril/valsartan: beyond natriuretic peptides

(2017) Jagdeep S S Singh et al.   HEART

Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα)Novelty and Significance

(2017) Joseph R. Burgoyne et al.   HYPERTENSION

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure

(2017) Markus Follmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

NO-Sensitive Guanylate Cyclase Isoforms NO-GC1 and NO-GC2 Contribute to Noise-Induced Inner Hair Cell Synaptopathy

(2017) Dorit Möhrle et al.   MOLECULAR PHARMACOLOGY

Anti-fibrotic effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence

(2017) Peter Sandner et al.   RESPIRATORY MEDICINE

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

(2017) David A. Baker et al.   Nature Communications

Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer

(2017) Allison A. Aka et al.   Expert Review of Clinical Pharmacology

New Pharmacological Strategies to Increase cGMP

(2016) Alessia Buglioni et al.   Annual Review of Medicine

Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G

(2016) Peter P. Rainer et al.   CARDIOVASCULAR RESEARCH

Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology

(2016) JM Oettrich et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Targeting NO/cGMP Signaling in the CNS for Neurodegeneration and Alzheimer’s Disease

(2016) Manel Aissa et al.   CURRENT MEDICINAL CHEMISTRY

Physiological Functions of NO-Sensitive Guanylyl Cyclase Isoforms

(2016) Doris Koesling et al.   CURRENT MEDICINAL CHEMISTRY

The Potential of sGC Modulators for the Treatment of Age-Related Fibrosis: A Mini-Review

(2016) Peter Sandner et al.   GERONTOLOGY

Molecular Physiology of Membrane Guanylyl Cyclase Receptors

(2016) Michaela Kuhn   PHYSIOLOGICAL REVIEWS

Cyclic GMP in Vascular RelaxationSignificance

(2015) Christian Krawutschke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood

(2015) C. Reiss et al.   BRITISH JOURNAL OF PHARMACOLOGY

PDE-5 Inhibitors: Clinical Points

(2015) Michael Doumas et al.   CURRENT DRUG TARGETS

Renal effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence

(2015) Johannes-Peter Stasch et al.   CURRENT OPINION IN PHARMACOLOGY

Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: insights from PARADIGM-HF

(2015) Pardeep S. Jhund et al.   EUROPEAN HEART JOURNAL

Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction

(2015) Mihai Gheorghiade et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

From bedside to bench—meeting report of the 7th International Conference on cGMP “cGMP: generators, effectors and therapeutic implications” in Trier, Germany, from June 19th to 21st 2015

(2015) Andreas Friebe et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The molecular targets of approved treatments for pulmonary arterial hypertension

(2015) Marc Humbert et al.   THORAX

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

(2015) Mahmood M. Alam et al.   Nature Communications

Pericytes in Chronic Lung Disease

(2014) Jessica E. Rowley et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Nitric Oxide and Heat Shock Protein 90 Activate Soluble Guanylate Cyclase by Driving Rapid Change in Its Subunit Interactions and Heme Content

(2014) Arnab Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial C-type natriuretic peptide maintains vascular homeostasis

(2014) Amie J. Moyes et al.   JOURNAL OF CLINICAL INVESTIGATION

cGMP: transition from bench to bedside: a report of the 6th International Conference on cGMP Generators, Effectors and Therapeutic Implications

(2014) Linda S. Hoffmann et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections

(2013) Dong-chuan Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HNO Enhances SERCA2a Activity and Cardiomyocyte Function by Promoting Redox-Dependent Phospholamban Oligomerization

(2013) Vidhya Sivakumaran et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitroxyl (HNO)

(2013) Hani N. Sabbah et al.   Circulation-Heart Failure

Evaluation of the Therapeutic Potential of a CNP Analog in a Fgfr3 Mouse Model Recapitulating Achondroplasia

(2012) Florence Lorget et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Large-scale association analysis identifies new risk loci for coronary artery disease

(2012) Panos Deloukas et al.   NATURE GENETICS

cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function

(2012) Mirko Jaumann et al.   NATURE MEDICINE

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension

(2012) Oleksandra Prysyazhna et al.   NATURE MEDICINE

A Novel PDE2A Reporter Cell Line: Characterization of the Cellular Activity of PDE Inhibitors

(2008) Frank Wunder et al.   MOLECULAR PHARMACEUTICS