The role of semaphorins in immune responses and autoimmune rheumatic diseases

Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma

(2017) Hesam Movassagh et al.   JOURNAL OF IMMUNOLOGY

Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis

(2016) Zahava Vadasz et al.   CLINICAL IMMUNOLOGY

CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP

(2016) Chizuru Akatsu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Safety, Pharmacokinetics, and Pharmacodynamics of a Humanized Anti-Semaphorin 4D Antibody, in a First-In-Human Study of Patients with Advanced Solid Tumors

(2015) A. Patnaik et al.   CLINICAL CANCER RESEARCH

Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice

(2015) Naoya Yamashita et al.   INTERNATIONAL IMMUNOLOGY

Semaphorin 4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor

(2015) Hai-Ying Peng et al.   JOURNAL OF BIOSCIENCES

Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis

(2015) A. Bertram et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Semaphorin 3A: an immunoregulator in systemic sclerosis

(2015) Doron Rimar et al.   RHEUMATOLOGY INTERNATIONAL

Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis

(2015) Celestina Mazzotta et al.   ARTHRITIS RESEARCH & THERAPY

Expression of Semaphorin 4A and its potential role in rheumatoid arthritis

(2015) Lin Wang et al.   ARTHRITIS RESEARCH & THERAPY

Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis

(2015) Svetlana P. Chapoval   ARTHRITIS RESEARCH & THERAPY

Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications

(2015) Yuji Yoshida et al.   Arthritis & Rheumatology

Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D

(2015) Elizabeth E Evans et al.   OncoImmunology

TheSEM6A6Locus Is Not Associated With Granulomatosis With Polyangiitis or Other Forms of Antineutrophil Cytoplasmic Antibody-Associated Vasculitides in Europeans: Comment on the Article by Xie et al

(2014) Stefan Wieczorek et al.   Arthritis & Rheumatology

Secreted Semaphorin 5A Activates Immune Effector Cells and Is a Biomarker for Rheumatoid Arthritis

(2014) Christiane Gras et al.   Arthritis & Rheumatology

Association of Granulomatosis With Polyangiitis (Wegener's) WithHLA-DPB1*04andSEMA6AGene Variants: Evidence From Genome-Wide Analysis

(2013) Gang Xie et al.   ARTHRITIS AND RHEUMATISM

Decreased Semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis

(2013) Shu Takagawa et al.   BMC MUSCULOSKELETAL DISORDERS

Neuroimmune semaphorin 4A as a drug and drug target for asthma

(2013) G. Mogie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

A regulatory role for CD72 expression on B cells in systemic lupus erythematosus

(2013) Zahava Vadasz et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration

(2013) Satoshi Nojima et al.   Nature Communications

Emerging Role of Semaphorins as Major Regulatory Signals and Potential Therapeutic Targets in Cancer

(2012) Luca Tamagnone   CANCER CELL

Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival

(2012) T. Toyofuku et al.   GENES & DEVELOPMENT

The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function

(2012) Deborah A. Witherden et al.   IMMUNITY

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

(2012) Federica Maione et al.   JOURNAL OF CLINICAL INVESTIGATION

Semaphorin 3A – a marker for disease activity and a potential putative disease-modifying treatment in systemic lupus erythematosus

(2012) Z Vadasz et al.   LUPUS

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Getting neural circuits into shape with semaphorins

(2012) R. Jeroen Pasterkamp   NATURE REVIEWS NEUROSCIENCE

Diverse roles for semaphorin−plexin signaling in the immune system

(2012) Hyota Takamatsu et al.   TRENDS IN IMMUNOLOGY

Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease

(2011) Ye Gan et al.   ARTHRITIS AND RHEUMATISM

Peripheral blood lymphocytes analysis detects CD100/SEMA4D alteration in systemic sclerosis patients

(2011) Alina Besliu et al.   AUTOIMMUNITY

Identification of Semaphorin 4B as a Negative Regulator of Basophil-Mediated Immune Responses

(2011) Y. Nakagawa et al.   JOURNAL OF IMMUNOLOGY

The involvement of immune semaphorins and neuropilin-1 in lupus nephritis

(2011) Z Vadasz et al.   LUPUS

Suppression of bone formation by osteoclastic expression of semaphorin 4D

(2011) Takako Negishi-Koga et al.   NATURE MEDICINE

Class 5 Transmembrane Semaphorins Control Selective Mammalian Retinal Lamination and Function

(2011) Ryota L. Matsuoka et al.   NEURON

Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

(2010) Andrea Casazza et al.   JOURNAL OF CLINICAL INVESTIGATION

Plexin-A4–semaphorin 3A signaling is required for Toll-like receptor– and sepsis-induced cytokine storm

(2010) Haitao Wen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Neuroimmune Semaphorin-3A Reduces Inflammation and Progression of Experimental Autoimmune Arthritis

(2010) A. Catalano   JOURNAL OF IMMUNOLOGY

CD72 Negatively Regulates KIT-Mediated Responses in Human Mast Cells

(2010) Tatsuki R. Kataoka et al.   JOURNAL OF IMMUNOLOGY

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II

(2010) Hyota Takamatsu et al.   NATURE IMMUNOLOGY

Anti–neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis

(2009) Jin-Sun Kong et al.   ARTHRITIS AND RHEUMATISM

Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis

(2009) Anguraj Sadanandam et al.   MICROVASCULAR RESEARCH

PlexinD1 Glycoprotein Controls Migration of Positively Selected Thymocytes into the Medulla

(2008) Young I. Choi et al.   IMMUNITY

Plexin-A4 negatively regulates T lymphocyte responses

(2008) Midori Yamamoto et al.   INTERNATIONAL IMMUNOLOGY

Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages

(2008) Jose Rafael Sierra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses

(2008) B. P. O'Connor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA