Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

Mechanisms of Autoantibody-Induced Pathology

(2017) Ralf J. Ludwig et al.   Frontiers in Immunology

Aptamer BC007 for neutralization of pathogenic autoantibodies directed against G-protein coupled receptors: A vision of future treatment of patients with cardiomyopathies and positivity for those autoantibodies

(2016) Gerd Wallukat et al.   ATHEROSCLEROSIS

Antibodies against angiotensin II type 1 receptor (AT1R) and endothelin receptor type A (ETAR) in systemic sclerosis (SSc)-response

(2016) Gabriela Riemekasten et al.   AUTOIMMUNITY REVIEWS

Vascular hypothesis revisited: Role of stimulating antibodies against angiotensin and endothelin receptors in the pathogenesis of systemic sclerosis

(2016) Otavio Cabral-Marques et al.   AUTOIMMUNITY REVIEWS

Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome

(2016) Madlen Loebel et al.   BRAIN BEHAVIOR AND IMMUNITY

Monocytic Angiotensin and Endothelin Receptor Imbalance Modulate Secretion of the Profibrotic Chemokine Ligand 18

(2016) J. Rademacher et al.   JOURNAL OF RHEUMATOLOGY

Localization and function of the renal calcium-sensing receptor

(2016) Daniela Riccardi et al.   Nature Reviews Nephrology

Autoantibodies against β1-adrenoceptor induce blood glucose enhancement and insulin insufficient via T lymphocytes

(2015) Yulin Gong et al.   IMMUNOLOGIC RESEARCH

Chemokines, their receptors and human disease: the good, the bad and the itchy

(2015) Vanessa L Bryant et al.   IMMUNOLOGY AND CELL BIOLOGY

Molecular Mechanisms Underlying β-Adrenergic Receptor-Mediated Cross-Talk between Sympathetic Neurons and Immune Cells

(2015) Dianne Lorton et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

Functional Autoantibodies in Systemic Sclerosis Pathogenesis

(2015) Angela Kill et al.   Current Rheumatology Reports

Anti-Endothelin Receptor Type A Autoantibodies in Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension

(2015) Li Guo et al.   Arthritis & Rheumatology

Adrenergic regulation of innate immunity: a review

(2015) Angela Scanzano et al.   Frontiers in Pharmacology

Vascular Receptor Autoantibodies in Pulmonary Arterial Hypertension Associated with Systemic Sclerosis

(2014) Mike O. Becker et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A novel luminescence-based method for the detection of functionally active antibodies to muscarinic acetylcholine receptors of the M3 type (mAchR3) in patients' sera

(2014) B. Preuss et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Serum CCL18 is predictive for lung disease progression and mortality in systemic sclerosis

(2014) J. Schupp et al.   EUROPEAN RESPIRATORY JOURNAL

The role of angiotensin II type 1 receptor-activating antibodies in patients with lupus nephritis

(2014) J. Xiong et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Muscarinic acetylcholine receptors: novel opportunities for drug development

(2014) Andrew C. Kruse et al.   NATURE REVIEWS DRUG DISCOVERY

Angiotensin receptor type 1 and endothelin receptor type A on immune cells mediate migration and the expression of IL-8 and CCL18 when stimulated by autoantibodies from systemic sclerosis patients

(2014) Jeannine Günther et al.   ARTHRITIS RESEARCH & THERAPY

Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis

(2014) Angela Kill et al.   ARTHRITIS RESEARCH & THERAPY

Tubulin, actin and heterotrimeric G proteins: Coordination of signaling and structure

(2013) Jeffrey M. Schappi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Calcium-Sensing Receptor Autoantibodies and Idiopathic Hypoparathyroidism

(2013) Neeraj Tomar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

First Clinical Experience with TRV027: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

(2013) David G. Soergel et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Identification of human CCR8 as a CCL18 receptor

(2013) Sabina A. Islam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Different actions of endothelin-1 on chemokine production in rat cultured astrocytes: reduction of CX3CL1/fractalkine and an increase in CCL2/MCP-1 and CXCL1/CINC-1

(2013) Yutaka Koyama et al.   Journal of Neuroinflammation

The inhibitory effects of antimuscarinic autoantibodies in the sera of primary Sjogren syndrome patients on the gastrointestinal motility

(2013) Kyungpyo Park et al.   MOLECULAR IMMUNOLOGY

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

β1-Adrenoceptor Autoantibodies from DCM Patients Enhance the Proliferation of T Lymphocytes through the β1-AR/cAMP/PKA and p38 MAPK Pathways

(2013) Yunhui Du et al.   PLoS One

Agonistic anti-ICAM-1 antibodies in scleroderma: Activation of endothelial pro-inflammatory cascades

(2013) Sabine I. Wolf et al.   VASCULAR PHARMACOLOGY

The Activity of CCL18 is Principally Mediated through Interaction with Glycosaminoglycans

(2013) Sonja Krohn et al.   Frontiers in Immunology

Drug-like actions of autoantibodies against receptors of the autonomous nervous system and their impact on human heart function

(2012) LR Herda et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth

(2012) Faye M Drawnel et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRV120027, a Novel β-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

(2012) Guido Boerrigter et al.   Circulation-Heart Failure

β1-adrenergic receptor autoantibodies from heart failure patients enhanced TNF-α secretion in RAW264.7 macrophages in a largely PKA-dependent fashion

(2012) Yunhui Du et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Deciphering actin cytoskeletal function in the contractile vascular smooth muscle cell

(2012) Rina Yamin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts

(2012) X. Shi-wen et al.   RHEUMATOLOGY

Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries

(2011) Sergio de Frutos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Antibodies interfering with the type 3 muscarinic receptor pathway inhibit gastrointestinal motility and cholinergic neurotransmission in Sjögren's syndrome

(2011) Kyungpyo Park et al.   ARTHRITIS AND RHEUMATISM

A family tree of vertebrate chemokine receptors for a unified nomenclature

(2011) Hisayuki Nomiyama et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Role of anti-β1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction

(2011) Marcela Segovia et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Immunoadsorption (IAS) for systemic lupus erythematosus

(2011) GH Stummvoll   LUPUS

Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome

(2011) Danielle Kohr et al.   PAIN

First report of anti-calcium-sensing receptor antibodies in a patient with Sjogren's syndrome and primary hypoparathyroidism

(2011) H. E. Harris et al.   RHEUMATOLOGY

Peptide-based ELISAs are not sensitive and specific enough to detect muscarinic receptor type 3 autoantibodies in serum from patients with Sjogren's syndrome

(2010) N. Roescher et al.   ANNALS OF THE RHEUMATIC DISEASES

Involvement of functional autoantibodies against vascular receptors in systemic sclerosis

(2010) G. Riemekasten et al.   ANNALS OF THE RHEUMATIC DISEASES

New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome

(2010) H. Tsuboi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Long-term active immunization with a synthetic peptide corresponding to the second extracellular loop of β1-adrenoceptor induces both morphological and functional cardiomyopathic changes in rats

(2010) Lin Zuo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Autoantibodies against the platelet-derived growth factor receptor in scleroderma: Comment on the articles by Classen et al and Loizos et al

(2009) Armando Gabrielli et al.   ARTHRITIS AND RHEUMATISM

CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients

(2009) P. Enghard et al.   ARTHRITIS AND RHEUMATISM

The proadhesive phenotype of systemic sclerosis skin promotes myeloid cell adhesion via ICAM-1 and VCAM-1

(2009) B. J. Rabquer et al.   RHEUMATOLOGY

Muscarinic-3 acetylcholine receptor autoantibody in patients with systemic sclerosis: contribution to severe gastrointestinal tract dysmotility

(2008) Y Kawaguchi et al.   ANNALS OF THE RHEUMATIC DISEASES

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

(2008) I Wessler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Physiologic Properties and Regulation of the Actin Cytoskeleton in Vascular Smooth Muscle

(2008) Dale D. Tang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Role of muscarinic receptors in the regulation of immune and inflammatory responses

(2008) Seddigheh Razani-Boroujerdi et al.   JOURNAL OF NEUROIMMUNOLOGY

Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice

(2006) T Unno et al.   BRITISH JOURNAL OF PHARMACOLOGY