标题
Targeting glutamate signalling in depression: progress and prospects
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 16, Issue 7, Pages 472-486
出版商
Springer Nature
发表日期
2017-03-17
DOI
10.1038/nrd.2017.16
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Change in cytokine levels is not associated with rapid antidepressant response to ketamine in treatment-resistant depression
- (2017) Minkyung Park et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression
- (2016) C. K. Loo et al. ACTA PSYCHIATRICA SCANDINAVICA
- A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression
- (2016) Jaskaran B. Singh et al. AMERICAN JOURNAL OF PSYCHIATRY
- Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation
- (2016) Cristina Cusin et al. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
- Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study
- (2016) Jaskaran B. Singh et al. BIOLOGICAL PSYCHIATRY
- Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling
- (2016) Eléonore Beurel et al. BIPOLAR DISORDERS
- Oral ketamine for the treatment of pain and treatment-resistant depression
- (2016) Robert A. Schoevers et al. BRITISH JOURNAL OF PSYCHIATRY
- NMDA antagonist treatment of depression
- (2016) Nolan R Williams et al. CURRENT OPINION IN NEUROBIOLOGY
- Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate
- (2016) Darragh Downey et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder
- (2016) James W. Murrough et al. HUMAN BRAIN MAPPING
- Ketamine administration reduces amygdalo-hippocampal reactivity to emotional stimulation
- (2016) Milan Scheidegger et al. HUMAN BRAIN MAPPING
- An assessment of the anti-fatigue effects of ketamine from a double-blind, placebo-controlled, crossover study in bipolar disorder
- (2016) Leorey N. Saligan et al. JOURNAL OF AFFECTIVE DISORDERS
- A New Perspective on the Anti-Suicide Effects With Ketamine Treatment
- (2016) Yena Lee et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects
- (2016) G M I Chowdhury et al. MOLECULAR PSYCHIATRY
- NMDAR inhibition-independent antidepressant actions of ketamine metabolites
- (2016) Panos Zanos et al. NATURE
- Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
- (2016) Ronald S Duman et al. NATURE MEDICINE
- Deuterated drugs draw heavier backing
- (2016) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Efficacy and Safety of Basimglurant as Adjunctive Therapy for Major Depression
- (2016) Jorge A. Quiroz et al. JAMA Psychiatry
- ABCB1gene variants and antidepressant treatment outcome: A meta-analysis
- (2015) Barbara Breitenstein et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression
- (2015) D. Jeffrey Newport et al. AMERICAN JOURNAL OF PSYCHIATRY
- Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics
- (2015) Chadi G. Abdallah et al. Annual Review of Medicine
- Serum Interleukin-6 Is a Predictive Biomarker for Ketamine’s Antidepressant Effect in Treatment-Resistant Patients With Major Depression
- (2015) Jian-jun Yang et al. BIOLOGICAL PSYCHIATRY
- Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex
- (2015) Laura Jiménez-Sánchez et al. CEREBRAL CORTEX
- COGNITION-CHILDHOOD MALTREATMENT INTERACTIONS IN THE PREDICTION OF ANTIDEPRESSANT OUTCOMES IN MAJOR DEPRESSIVE DISORDER PATIENTS: RESULTS FROM THE iSPOT-D TRIAL
- (2015) Shefali Miller et al. DEPRESSION AND ANXIETY
- Single-Dose Ketamine Followed by Daily d-Cycloserine in Treatment-Resistant Bipolar Depression
- (2015) Joshua T. Kantrowitz et al. JOURNAL OF CLINICAL PSYCHIATRY
- Randomized Proof of Concept Trial of GLYX-13, an N-Methyl-D-Aspartate Receptor Glycine Site Partial Agonist, in Major Depressive Disorder Nonresponsive to a Previous Antidepressant Agent
- (2015) SHELDON PRESKORN et al. Journal of Psychiatric Practice
- Neural correlates of change in major depressive disorder anhedonia following open-label ketamine
- (2015) Níall Lally et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Sex differences in glutamate receptor gene expression in major depression and suicide
- (2015) A L Gray et al. MOLECULAR PSYCHIATRY
- A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder
- (2015) M S Milak et al. MOLECULAR PSYCHIATRY
- Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder
- (2015) G I Papakostas et al. MOLECULAR PSYCHIATRY
- The Genetics of Stress-Related Disorders: PTSD, Depression and Anxiety Disorders
- (2015) Jordan W Smoller NEUROPSYCHOPHARMACOLOGY
- Amygdala Reactivity to Emotional Faces in the Prediction of General and Medication-Specific Responses to Antidepressant Treatment in the Randomized iSPOT-D Trial
- (2015) Leanne M Williams et al. NEUROPSYCHOPHARMACOLOGY
- Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+channels in unconsciousness
- (2015) Soonwook Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Single i.v. ketamine augmentation of newly initiated escitalopram for major depression: results from a randomized, placebo-controlled 4-week study
- (2015) Y.-D. Hu et al. PSYCHOLOGICAL MEDICINE
- Ketamine for rapid reduction of suicidal ideation: a randomized controlled trial
- (2015) J. W. Murrough et al. PSYCHOLOGICAL MEDICINE
- Large-Scale Network Dysfunction in Major Depressive Disorder
- (2015) Roselinde H. Kaiser et al. JAMA Psychiatry
- R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects
- (2015) C Yang et al. Translational Psychiatry
- Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder
- (2015) J W Murrough et al. Translational Psychiatry
- Glutamate Metabolism in Major Depressive Disorder
- (2014) Chadi G. Abdallah et al. AMERICAN JOURNAL OF PSYCHIATRY
- A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder
- (2014) Kyle A.B. Lapidus et al. BIOLOGICAL PSYCHIATRY
- Effects of Striatal ΔFosB Overexpression and Ketamine on Social Defeat Stress–Induced Anhedonia in Mice
- (2014) Rachel J. Donahue et al. BIOLOGICAL PSYCHIATRY
- Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States
- (2014) Katharina L. Dürr et al. CELL
- EFFECTS OF KETAMINE ON EXPLICIT AND IMPLICIT SUICIDAL COGNITION: A RANDOMIZED CONTROLLED TRIAL IN TREATMENT-RESISTANT DEPRESSION
- (2014) Rebecca B. Price et al. DEPRESSION AND ANXIETY
- Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression
- (2014) Michelle J. Chandley et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression
- (2014) Paulo R. Shiroma et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Do the dissociative side effects of ketamine mediate its antidepressant effects?
- (2014) David A. Luckenbaugh et al. JOURNAL OF AFFECTIVE DISORDERS
- Ketamine Safety and Tolerability in Clinical Trials for Treatment-Resistant Depression
- (2014) Le-Ben Wan et al. JOURNAL OF CLINICAL PSYCHIATRY
- A Targeted Multiplexed Proteomic Investigation Identifies Ketamine-Induced Changes in Immune Markers in Rat Serum and Expression Changes in Protein Kinases/Phosphatases in Rat Brain
- (2014) Hendrik Wesseling et al. JOURNAL OF PROTEOME RESEARCH
- Improvement in suicidal ideation after ketamine infusion: Relationship to reductions in depression and anxiety
- (2014) Elizabeth D. Ballard et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Neurocognitive Effects of Ketamine and Association with Antidepressant Response in Individuals with Treatment-Resistant Depression: A Randomized Controlled Trial
- (2014) James W Murrough et al. NEUROPSYCHOPHARMACOLOGY
- Organization, control and function of extrasynaptic NMDA receptors
- (2014) T. Papouin et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses
- (2014) E. S. Gideons et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Review of the Clinical, Economic, and Societal Burden of Treatment-Resistant Depression: 1996–2013
- (2014) David A. Mrazek et al. PSYCHIATRIC SERVICES
- A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes
- (2014) A. McGirr et al. PSYCHOLOGICAL MEDICINE
- Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression
- (2014) N Lally et al. Translational Psychiatry
- Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial
- (2013) James W. Murrough et al. AMERICAN JOURNAL OF PSYCHIATRY
- Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses
- (2013) Bhavya Voleti et al. BIOLOGICAL PSYCHIATRY
- Inhibition of Glycine Transporter-I as a Novel Mechanism for the Treatment of Depression
- (2013) Chih-Chia Huang et al. BIOLOGICAL PSYCHIATRY
- Glycine Transporter-I Inhibitors: A New Class of Antidepressant?
- (2013) Sanjay J. Mathew BIOLOGICAL PSYCHIATRY
- Neural Correlates of Rapid Antidepressant Response to Ketamine in Treatment-Resistant Unipolar Depression: A Preliminary Positron Emission Tomography Study
- (2013) Paul J. Carlson et al. BIOLOGICAL PSYCHIATRY
- From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders
- (2013) Gerard Sanacora et al. BIOLOGICAL PSYCHIATRY
- Neural correlates of rapid antidepressant response to ketamine in bipolar disorder
- (2013) Allison C Nugent et al. BIPOLAR DISORDERS
- PREDICTIVE SOCIOECONOMIC AND CLINICAL PROFILES OF ANTIDEPRESSANT RESPONSE AND REMISSION
- (2013) Felipe A. Jain et al. DEPRESSION AND ANXIETY
- Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression
- (2013) C. N. Haile et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Augmentation of response and remission to serial intravenous subanesthetic ketamine in treatment resistant depression
- (2013) Paulo R. Shiroma et al. JOURNAL OF AFFECTIVE DISORDERS
- Repeated S-ketamine Infusions in Therapy Resistant Depression: A Case Series
- (2013) Felix Segmiller et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Serial infusions of low-dose ketamine for major depression
- (2013) Keith G Rasmussen et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010
- (2013) Harvey A Whiteford et al. LANCET
- Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
- (2013) G Sanacora et al. MOLECULAR PSYCHIATRY
- GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects
- (2013) Jeffrey Burgdorf et al. NEUROPSYCHOPHARMACOLOGY
- Conceptual Confluence: The Kynurenine Pathway as a Common Target for Ketamine and the Convergence of the Inflammation and Glutamate Hypotheses of Depression
- (2013) Andrew H Miller NEUROPSYCHOPHARMACOLOGY
- GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine
- (2013) Rong-Jian Liu et al. NEUROPSYCHOPHARMACOLOGY
- R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine
- (2013) Ji-chun Zhang et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Neurocognitive effects of ketamine in treatment-resistant major depression: association with antidepressant response
- (2013) James W. Murrough et al. PSYCHOPHARMACOLOGY
- Maximum Tolerated Dose Evaluation of the AMPA Modulator Org 26576 in Healthy Volunteers and Depressed Patients
- (2013) Kari R. Nations et al. Drugs in research & development
- Does Intraoperative Ketamine Attenuate Inflammatory Reactivity Following Surgery? A Systematic Review and Meta-Analysis
- (2012) Ola Dale et al. ANESTHESIA AND ANALGESIA
- Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Antidepressant Efficacy of Ketamine in Depressed Patients
- (2012) Gonzalo Laje et al. BIOLOGICAL PSYCHIATRY
- Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial
- (2012) Carlos A. Zarate et al. BIOLOGICAL PSYCHIATRY
- A Randomized Trial of a Low-Trapping Nonselective N-Methyl-D-Aspartate Channel Blocker in Major Depression
- (2012) Carlos A. Zarate et al. BIOLOGICAL PSYCHIATRY
- Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression
- (2012) James W. Murrough et al. BIOLOGICAL PSYCHIATRY
- Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder
- (2012) Wallace C. Duncan et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- A randomized add-on trial of high-dose d-cycloserine for treatment-resistant depression
- (2012) Uriel Heresco-Levy et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- A Randomized, Placebo-Controlled, Crossover Pilot Trial of the Oral Selective NR2B Antagonist MK-0657 in Patients With Treatment-Resistant Major Depressive Disorder
- (2012) Lobna Ibrahim et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial
- (2012) Kari R Nations et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology
- (2012) J M Stone et al. MOLECULAR PSYCHIATRY
- Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression
- (2012) Z.A. Hughes et al. NEUROPHARMACOLOGY
- Chronic Ketamine Administration Modulates Midbrain Dopamine System in Mice
- (2012) Sijie Tan et al. PLoS One
- Synaptic Dysfunction in Depression: Potential Therapeutic Targets
- (2012) R. S. Duman et al. SCIENCE
- Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 PET and Postmortem Study
- (2011) Alexandra Deschwanden et al. AMERICAN JOURNAL OF PSYCHIATRY
- Too Many Cooks? Intrinsic and Synaptic Homeostatic Mechanisms in Cortical Circuit Refinement
- (2011) Gina Turrigiano Annual Review of Neuroscience
- Structural Neuroimaging Studies in Major Depressive Disorder
- (2011) Matthew J. Kempton ARCHIVES OF GENERAL PSYCHIATRY
- Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice
- (2011) E Beurel et al. MOLECULAR PSYCHIATRY
- Grand challenges in global mental health
- (2011) Pamela Y. Collins et al. NATURE
- NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
- (2011) Anita E. Autry et al. NATURE
- A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression
- (2010) Nancy Diazgranados et al. ARCHIVES OF GENERAL PSYCHIATRY
- Magnetic Resonance Spectroscopy Studies of Glutamate-Related Abnormalities in Mood Disorders
- (2010) Cagri Yüksel et al. BIOLOGICAL PSYCHIATRY
- Challenges for and current status of research into positive modulators of AMPA receptors
- (2010) Simon E Ward et al. BRITISH JOURNAL OF PHARMACOLOGY
- Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos
- (2010) Junbo Liu et al. NATURE CELL BIOLOGY
- Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
- (2010) Giles E. Hardingham et al. NATURE REVIEWS NEUROSCIENCE
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
- (2010) N. Li et al. SCIENCE
- Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression
- (2009) Rebecca B. Price et al. BIOLOGICAL PSYCHIATRY
- Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression
- (2009) Marije aan het Rot et al. BIOLOGICAL PSYCHIATRY
- Brain-Derived Neurotrophic Factor and Initial Antidepressant Response to anN-Methyl-D-Aspartate Antagonist
- (2009) Rodrigo Machado-Vieira et al. JOURNAL OF CLINICAL PSYCHIATRY
- Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity
- (2009) R. I. Stanika et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glutamate-based antidepressants: 20 years on
- (2009) Phil Skolnick et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Glutamate and the Neural Basis of the Subjective Effects of Ketamine
- (2008) J. F. William Deakin et al. ARCHIVES OF GENERAL PSYCHIATRY
- Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression
- (2008) Beata Karolewicz et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder
- (2008) Sheldon H. Preskorn et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole
- (2008) M Banasr et al. MOLECULAR PSYCHIATRY
- The molecular neurobiology of depression
- (2008) Vaishnav Krishnan et al. NATURE
- Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
- (2008) Gerard Sanacora et al. NATURE REVIEWS DRUG DISCOVERY
- A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral–CA1 synapses in hippocampus
- (2008) Xiao-lei Zhang et al. NEUROPHARMACOLOGY
- Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression
- (2008) Anteneh M. Feyissa et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors
- (2007) Sungho Maeng et al. BIOLOGICAL PSYCHIATRY
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