PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1

Neuroimmunity: Physiology and Pathology

(2016) Sébastien Talbot et al.   Annual Review of Immunology

SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons

(2016) Qingjian Han et al.   NEURON

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain

(2015) Deepitha Selvaraj et al.   CANCER CELL

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

(2015) Sonja Kleffel et al.   CELL

Nivolumab: targeting PD-1 to bolster antitumor immunity

(2015) Julie R Brahmer et al.   Future Oncology

Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion

(2015) Gang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and Antitumor Activity of Anti–PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer

(2015) Junzo Hamanishi et al.   JOURNAL OF CLINICAL ONCOLOGY

Delayed Activation of Spinal Microglia Contributes to the Maintenance of Bone Cancer Pain in Female Wistar Rats via P2X7 Receptor and IL-18

(2015) Y. Yang et al.   JOURNAL OF NEUROSCIENCE

Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

(2015) Jeffrey S Weber et al.   LANCET ONCOLOGY

PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy

(2015) S. P. Patel et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

(2015) Zhen-Zhong Xu et al.   NATURE MEDICINE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Crosstalk between the nociceptive and immune systems in host defence and disease

(2015) Stephen B. McMahon et al.   NATURE REVIEWS NEUROSCIENCE

Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma

(2015) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

(2015) Stephen M. Ansell et al.   NEW ENGLAND JOURNAL OF MEDICINE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

(2014) Temugin Berta et al.   JOURNAL OF CLINICAL INVESTIGATION

TREK2 Expressed Selectively in IB4-Binding C-Fiber Nociceptors Hyperpolarizes Their Membrane Potentials and Limits Spontaneous Pain

(2014) C. Acosta et al.   JOURNAL OF NEUROSCIENCE

Toll-Like Receptor 4 Signaling Contributes to Paclitaxel-Induced Peripheral Neuropathy

(2014) Yan Li et al.   JOURNAL OF PAIN

Painful and painless channelopathies

(2014) David L H Bennett et al.   LANCET NEUROLOGY

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Transmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control

(2014) João Braz et al.   NEURON

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

The Neurobiology of Cancer Pain

(2014) Brian L. Schmidt   NEUROSCIENTIST

SHP-1 phosphatase activity counteracts increased T cell receptor affinity

(2013) Michael Hebeisen et al.   JOURNAL OF CLINICAL INVESTIGATION

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

Bone cancer pain: Causes, consequences, and therapeutic opportunities

(2013) Patrick Mantyh   PAIN

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain

(2011) Juan Miguel Jimenez-Andrade et al.   PAIN

Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve

(2010) Nurcan Üçeyler et al.   EXPERIMENTAL NEUROLOGY

Overcoming obstacles to developing new analgesics

(2010) Clifford J Woolf   NATURE MEDICINE

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Hematopoietic colony–stimulating factors mediate tumor-nerve interactions and bone cancer pain

(2009) Matthias Schweizerhof et al.   NATURE MEDICINE

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Critical role of nociceptor plasticity in chronic pain

(2009) David B. Reichling et al.   TRENDS IN NEUROSCIENCES

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology