The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity

Seizing Control of KCC2: A New Therapeutic Target for Epilepsy

(2017) Yvonne E. Moore et al.   TRENDS IN NEUROSCIENCES

Enhancing KCC2 function counteracts morphine-induced hyperalgesia

(2017) Francesco Ferrini et al.   Scientific Reports

Diminished KCC2 confounds synapse specificity of LTP during senescence

(2016) Isabella Ferando et al.   NATURE NEUROSCIENCE

Stress Increases Ethanol Self-Administration via a Shift toward Excitatory GABA Signaling in the Ventral Tegmental Area

(2016) Alexey Ostroumov et al.   NEURON

Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo

(2015) S. Sivakumaran et al.   JOURNAL OF NEUROSCIENCE

KCC2 function modulates in vitro ictogenesis

(2015) Shabnam Hamidi et al.   NEUROBIOLOGY OF DISEASE

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

(2015) Perrine Friedel et al.   Science Signaling

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

(2015) Perrine Friedel et al.   Science Signaling

Disrupted Cl−homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states

(2013) Tarek Z. Deeb et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Visualization of Synaptic Inhibition with an Optogenetic Sensor Developed by Cell-Free Protein Engineering Automation

(2013) J. S. Grimley et al.   JOURNAL OF NEUROSCIENCE

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Improved method for efficient imaging of intracellular Cl− with Cl-Sensor using conventional fluorescence setup

(2013) Perrine Friedel et al.   Frontiers in Molecular Neuroscience

Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: Development of a highly selective and more potent in vitro probe

(2012) Eric Delpire et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival

(2011) Christophe Pellegrino et al.   JOURNAL OF PHYSIOLOGY-LONDON

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

(2009) E. Delpire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA