Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

(2017) Cassandra N. Spracklen et al.   HUMAN MOLECULAR GENETICS

Coding-sequence variants are associated with blood lipid levels in 14,473 Chinese

(2016) Xiangfeng Lu et al.   HUMAN MOLECULAR GENETICS

Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease

(2016) Anna Helgadottir et al.   NATURE GENETICS

Risk factors and biomarkers of age-related macular degeneration

(2016) Nathan G. Lambert et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Genetic Susceptibility to Lipid Levels and Lipid Change Over Time and Risk of Incident Hyperlipidemia in Chinese PopulationsCLINICAL PERSPECTIVE

(2015) Xiangfeng Lu et al.   Circulation-Cardiovascular Genetics

Mitochondrial calcium and the regulation of metabolism in the heart

(2015) George S.B. Williams et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The impact of low-frequency and rare variants on lipid levels

(2015) Ida Surakka et al.   NATURE GENETICS

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

A method to predict the impact of regulatory variants from DNA sequence

(2015) Dongwon Lee et al.   NATURE GENETICS

Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese

(2015) Clara S. Tang et al.   Nature Communications

Genetic Susceptibility to Lipid Levels and Lipid Change Over Time and Risk of Incident Hyperlipidemia in Chinese PopulationsCLINICAL PERSPECTIVE

(2015) Xiangfeng Lu et al.   Circulation-Cardiovascular Genetics

Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

(2014) Leslie A. Lange et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks

(2014) Gina M. Peloso et al.   AMERICAN JOURNAL OF HUMAN GENETICS

RAREMETAL: fast and powerful meta-analysis for rare variants

(2014) S. Feng et al.   BIOINFORMATICS

Rare Coding Variants and Breast Cancer Risk: Evaluation of Susceptibility Loci Identified in Genome-Wide Association Studies

(2014) Y. Zhang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease

(2014) Robert S. Rosenson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

(2014) Oddgeir L Holmen et al.   NATURE GENETICS

The potential of novel biomarkers to improve risk prediction of type 2 diabetes

(2013) Christian Herder et al.   DIABETOLOGIA

Meta-analysis of gene-level tests for rare variant association

(2013) Dajiang J Liu et al.   NATURE GENETICS

Common variants associated with plasma triglycerides and risk for coronary artery disease

(2013) Ron Do et al.   NATURE GENETICS

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

(2013) Ying Wu et al.   PLoS Genetics

Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci

(2012) Folkert W. Asselbergs et al.   AMERICAN JOURNAL OF HUMAN GENETICS

zCall: a rare variant caller for array-based genotyping

(2012) Jacqueline I. Goldstein et al.   BIOINFORMATICS

Nonalcoholic fatty liver disease and lipids

(2012) Anthony S. Wierzbicki et al.   CURRENT OPINION IN LIPIDOLOGY

Soluble CD163: a biomarker linking macrophages and insulin resistance

(2012) T. Parkner et al.   DIABETOLOGIA

Cohort Profile: The HUNT Study, Norway

(2012) S. Krokstad et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

The accessible chromatin landscape of the human genome

(2012) Robert E. Thurman et al.   NATURE

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

(2012) Xiangfeng Lu et al.   NATURE GENETICS

Large-scale genome-wide association studies in east Asians identify new genetic loci influencing metabolic traits

(2011) Young Jin Kim et al.   NATURE GENETICS

Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability

(2011) Serena Sanna et al.   PLoS Genetics

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease

(2009) Lena M.S. Carlsson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Linkage and Genome-wide Association Analysis of Obesity-related Phenotypes: Association of Weight With the MGAT1 Gene

(2009) Åsa Johansson et al.   Obesity

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

APCSK9Missense Variant Associated with a Reduced Risk of Early-Onset Myocardial Infarction

(2008) Sekar Kathiresan   NEW ENGLAND JOURNAL OF MEDICINE