A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations

Chloride-Mediated Apoptosis-Inducing Activity of Bis(sulfonamide) Anionophores

(2016) Tanmoy Saha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

pH-Regulated Nonelectrogenic Anion Transport by Phenylthiosemicarbazones

(2016) Ethan N. W. Howe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nonprotonophoric Electrogenic Cl − Transport Mediated by Valinomycin-like Carriers

(2016) Xin Wu et al.   Chem

A Small Molecule Inhibitor of ATPase Activity of HSP70 Induces Apoptosis and Has Antitumor Activities

(2015) Sung-Kyun Ko et al.   CHEMISTRY & BIOLOGY

Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia

(2015) Hongyu Li et al.   Nature Chemistry

Does lipophilicity affect the effectiveness of a transmembrane anion transporter? Insight from squaramido-functionalized bis(choloyl) conjugates

(2015) Zhi Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cytosolic chloride ion is a key factor in lysosomal acidification and function of autophagy in human gastric cancer cell

(2014) Shigekuni Hosogi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells

(2014) Sung-Kyun Ko et al.   Nature Chemistry

Thiosquaramides: pH switchable anion transporters

(2014) Nathalie Busschaert et al.   Chemical Science

Lipophilic balance – a new design principle for transmembrane anion carriers

(2014) Hennie Valkenier et al.   Chemical Science

Application and interpretation of current autophagy inhibitors and activators

(2013) Ya-ping Yang et al.   ACTA PHARMACOLOGICA SINICA

Squaramide-based tripodal receptors for selective recognition of sulfate anion

(2013) Can Jin et al.   CHEMICAL COMMUNICATIONS

Towards predictable transmembrane transport: QSAR analysis of anion binding and transport

(2013) Nathalie Busschaert et al.   Chemical Science

Squaramides as Potent Transmembrane Anion Transporters

(2012) Nathalie Busschaert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chloride in Vesicular Trafficking and Function

(2012) Tobias Stauber et al.   Annual Review of Physiology

Autophagy-regulating small molecules and their therapeutic applications

(2012) Kyung-Hwa Baek et al.   CHEMICAL SOCIETY REVIEWS

Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas

(2012) Stephen J. Moore et al.   Chemical Science

JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry

(2012) A Perelman et al.   Cell Death & Disease

Ditopic Ion Transport Systems: Anion-π Interactions and Halogen Bonds at Work

(2011) Andreas Vargas Jentzsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Lysosomal pH and analysis of the counter ion pathways that support acidification

(2011) Jessica E. DiCiccio et al.   JOURNAL OF GENERAL PHYSIOLOGY

A Small Molecule That Binds to an ATPase Domain of Hsc70 Promotes Membrane Trafficking of Mutant Cystic Fibrosis Transmembrane Conductance Regulator

(2011) Hyungseoph J. Cho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure–Activity Relationships in Tripodal Transmembrane Anion Transporters: The Effect of Fluorination

(2011) Nathalie Busschaert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Apoptosis-Inducing Small Molecule That Binds to Heat Shock Protein 70

(2008) Darren R. Williams et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

(2008) Austin R. Graves et al.   NATURE

The Itinerary of Autophagosomes: From Peripheral Formation to Kiss-and-Run Fusion with Lysosomes

(2008) Luca Jahreiss et al.   TRAFFIC