Article
Biochemistry & Molecular Biology
Shuhei Nishizawa, Gaohong Tu, Daisuke Ogata, Kouichiro Miyauchi, Akihiro Ohkubo
Summary: In this study, modified bases that can recognize T-A base pairs were developed by introducing quinoline derivatives into antiparallel TFOs. The ability of these modified bases to form triplexes and discriminate between base pairs was evaluated.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Spectroscopy
Zahra Abolghasemi-Fakhri, Mohammad Amjadi
Summary: A facile method for preparing a gold nanostar-graphene quantum dot composite was reported, which resulted in highly active surfactant-free gold nanostars. The composite was used in a new sensing strategy for colorimetric detection of cysteine by studying its etching reaction with Na2SO3. Larger gold nanostars showed greater activity in the etching reaction, and pre-added cysteine protected the nanostars from etching, allowing for sensitive detection of cysteine with a detection limit of 0.35 nM.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Hari Chandana Yadavalli, Sooyeon Park, Yeolhoe Kim, Riddhi Nagda, Tae-Hwan Kim, Min Kyun Han, Il Lae Jung, Yong Joo Bhang, Won Ho Yang, Louise Torp Dalgaard, Seong Wook Yang, Pratik Shah
Summary: A novel method for sensing target microRNAs using innovative Tailed-Hoogsteen triplex DNA-encapsulated Silver Nanoclusters (DNA/AgNCs) is presented. Upon hybridization of specific microRNA with the tail, the Tailed-Hoogsteen triplex DNA/AgNCs exhibit a pronounced red fluorescence, effectively turning on the signal. The underlying mechanism is elucidated and demonstrates the utility of sensors for microRNA imaging with high sensitivity and specificity.
Article
Chemistry, Analytical
Huafeng Wang, Ting Fang, Hua Liu, Tianxiang Wei, Zhihui Dai
Summary: In this study, a plasmonic sensing platform based on gold nanostars was developed for ultrasensitive catechol detection. The platform exhibited high sensitivity and a wide detection range, making it applicable in various fields such as environmental monitoring, food safety, and disease diagnosis.
Article
Chemistry, Analytical
Huilin Sun, Yuntai Lv, Jiabao Zhang, Chenyu Zhou, Xingguang Su
Summary: A novel dual-signal sensing system for the determination of beta-galactosidase (β-Gal) activity was established using a dual-emission probe assembled from gold-platinum bimetallic nanoclusters (Au-Pt NCs) and rhodamine B. The detection platform based on Au-Pt NCs and rhodamine B showed the ability to sensitively detect β-Gal activity through ratiometric fluorescent and colorimetric methods. The developed assay method demonstrated good performance in quantitative detection of β-Gal in spiked serum samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Engineering, Environmental
Cuiyun Zhang, Lunjie Huang, Da-Wen Sun, Hongbin Pu
Summary: Gold nanorods functionalized with metal-phenolic networks (GNRs@MPNs) exhibit high efficiency in low doses for killing bacteria and accelerating wound healing.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Applied
Yubin Li, Lei Wang, Liting Zhao, Min Li, Yanmei Wen
Summary: An enzyme-free fluorescence resonance energy transfer (FRET) strategy based on triplex DNA and hybridization chain reaction amplification was established for sensitive detection of chloramphenicol (CAP) in milk. This method allows for accurate and rapid quantification of CAP, with a wide range of potential applications.
Article
Chemistry, Analytical
Xiaoming Ma, Hui Zhang, Jin Liu, Huifang Zhang, Xuan Hu, Yu Wang, Xun Li, Jianguo Xu
Summary: This article introduces an ultrahigh-resolution multicolor sensing platform for the specific detection of silver ions (Ag(I)), which can be used for environmental monitoring and food safety detection. By employing platinum nanoparticles (PtNPs) as nanozymes and binding with silver ions, the catalase-like activity responsible for hydrogen peroxide is hindered, resulting in highly oxidizing hydroxyl free radicals and etching of AuNRs. This method demonstrates a proportional response to the target concentration and is visible to the naked eye.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Nanoscience & Nanotechnology
Xinyu Liu, Chenyang Shen, Kedi Yu, Juan Huang, Yumin Leng, Guo Wang, Zhengbo Chen
Summary: Based on the synergetic catalysis of gold nanoparticles (AuNPs) and mercury, a simple and ultrasensitive colorimetric method for the determination of Hg2+ was established. By self-assembling two-dimensional (2D) AuNPs into an orderly distribution at the liquid/liquid interface, the detection of Hg2+ was achieved with improved repeatability and detection signal strength.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Analytical
Yue Qu, Tao Chen, Yuanhong Xu
Summary: It is urgent to develop a sulfur ion detection platform with good selectivity, sensitivity, and portability. In this study, a one-platform-two-channels detection method based on tin telluride (SnTe) nanobelts was constructed, which showed excellent selectivity and sensitivity. The detection platform could accurately visualize the concentration of S2- in 10 minutes with a wide detection range and low detection limit. A portable signal reading platform was established with the assistance of a smartphone.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Sarida Naorungroj, Prinjaporn Teengam, Tirayut Vilaivan, Orawon Chailapakul
Summary: A smartphone-assisted paper-based colorimetric assay was developed for early screening of HPV DNA, offering a simple, sensitive, and selective way of detection. The method quantifies DNA concentration by analyzing color changes, allowing for linear measurement in the range of 1 to 1000 nM.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Applied
Benediktas Brasiunas, Anton Popov, Arunas Ramanavicius, Almira Ramanaviciene
Summary: A colorimetric sensor based on a redox reaction between AuCl4- ions and reducing sugars was developed, with different sugars showing varied reaction rates and LOD values. The sensitivity of the sensor can be enhanced by prolonging the reaction time, and the linear range for different sugars differs, with distinct LOQ values observed.
Review
Chemistry, Multidisciplinary
Tushar Kant, Kamlesh Shrivas, Ankita Tejwani, Khushali Tandey, Anuradha Sharma, Shashi Gupta
Summary: This review provides a comprehensive overview of portable colorimetric chemical sensing devices and their applications in clinical, environmental, and food safety domains. It covers different types of devices, such as handheld, RGB-based, paper-based, and wearable, and explores the underlying principles, functional materials, and detection mechanisms.
Article
Chemistry, Analytical
Lijun Wang, Hong Zhou, Xue Wu, Yanfei Song, Yukun Huang, Xiao Yang, Xianggui Chen
Summary: A novel colorimetric aptasensor based on the peroxidase-like activity of Fe3O4@Cu nanoparticles and sandwich oligonucleotide hybridization has been developed for highly sensitive tetracycline (TC) detection. The proposed method has demonstrated excellent potential for highly sensitive TC detection in milk.
Article
Chemistry, Multidisciplinary
Yejian Wan, Jingwen Zhao, Xiaochun Deng, Jie Chen, Fengna Xi, Xiaobo Wang
Summary: Nanozymes based on carbonaceous nanomaterials have advantages over natural enzymes in terms of high stability, good biocompatibility, and the potential for multifunctionality through material engineering. A sensing platform utilizing nitrogen-doped graphene quantum dots has been developed, demonstrating high efficiency in detecting hydrogen peroxide and biomolecules with high sensitivity through a dual-modality colorimetric and fluorescent platform.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Analytical
Wanhe Wang, Jianhua Liu, Li-An Wu, Chung-Nga Ko, Xueliang Wang, Chuankai Lin, Jingqi Liu, Liansheng Ling, Jing Wang
Summary: This study presents a synergetic signal amplification system combining CRISPR-Cas12a and nicking enzyme-free strand displacement amplification (SDA) technique for accurate detection of prostate-specific antigen (PSA). The system successfully discriminated blood samples from prostate cancer patients among normal individuals/cancer patients.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Wanhe Wang, Jingqi Liu, Xiaoxia Li, Chuankai Lin, Xueliang Wang, Jianhua Liu, Liansheng Ling, Jing Wang
Summary: CRISPR/Cas12a-based biosensors have been widely studied for nucleic acid detection, but this study demonstrates their use in colorimetric detection of serum PSA using an enzyme-free HCR-powered system. The assay shows sensitive and selective detection capabilities in both visual and quantitative modes, highlighting its potential for protein cancer biomarker detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Food Science & Technology
Li Zou, Manjun Zhang, Mengyan Li, Zhiyou Xiao, Liansheng Ling
Summary: This study developed an enzyme-free fluorescent aptasensor using a dual signal amplification strategy for sensitive detection of aflatoxin B1. The aptasensor showed high sensitivity and selectivity, making it suitable for food safety control.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Huaguo Liang, Zexin Chen, Ruihui Yang, Qingsong Huang, Hongmei Chen, Wanting Chen, Li Zou, Peng Wei, Shijie Wei, Yongxia Yang, Yongli Zhang
Summary: The polyphenolic compound Methyl gallate (MG) found in plants can inhibit the proliferation, migration, and invasion of HCC cells both in vitro and in vivo. The therapeutic mechanism of MG potentially involves the regulation of the AMPK/NF-kappa B pathway, which influences the epithelial-mesenchymal transition and MMP expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Wanhe Wang, Xueliang Wang, Jingqi Liu, Chuankai Lin, Jianhua Liu, Jing Wang
Summary: This article introduces the combination of PCR and gold nanoparticles (AuNPs) to construct colorimetric sensing platforms for the visual detection of health-related DNA and proteins. Future trends and perspectives are also discussed.
Article
Chemistry, Analytical
Yufen Lai, Mengyan Li, Xiaofei Liao, Li Zou
Summary: In this study, a DNAzyme-regulated CRISPR/Cas12a cascade signal amplification strategy was developed for sensitive and selective detection of ALP activity and inhibition. The proposed method overcomes the shortcomings of conventional methods and shows great potential in clinical diagnosis and biomedical research.
ANALYTICA CHIMICA ACTA
(2022)
Article
Education, Scientific Disciplines
Huaguo Liang, Ying Wen, Wei Fang, Xiaoyan Cai, Xiangsheng Wang, Li Zou, Peng Wei, Baoyun Yang, Jiazheng Lu, Yongxia Yang, Yongli Zhang
Summary: This study investigated the antitumor activity of 2-Methoxy-1,4-naphthoquinone (MNQ) against hepatocellular carcinoma (HCC) cells, and found that MNQ can suppress tumor cell proliferation and induce apoptosis through mitochondrial and Rel/NF-κB signaling pathways.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2022)
Review
Chemistry, Analytical
Jing Wang, Xueliang Wang, Kai Yang, Sijun Hu, Wanhe Wang
Summary: This review discusses the use of self-assembled biomaterials based on small organic molecules for cancer theranostics. It highlights the applications of peptides, amphiphilic molecules, and aggregation-induced emission luminogens in cancer diagnosis and therapy. These applications demonstrate the potential of small molecule-based self-assembled biomaterials in precision medicine.
Article
Chemistry, Analytical
Mengyan Li, Ruoying Huang, Xiaofei Liao, Zidan Zhou, Li Zou, Bing Liu
Summary: In this study, a label-free fluorescent aptasensor based on the inner filter effect between gold nanoparticles (AuNPs) and graphene oxide quantum dots (GOQDs) was developed for the detection of kanamycin in complex samples. The aptasensor showed a linear relationship between the fluorescence intensity of GOQDs and the concentration of kanamycin, with a detection limit of 3.6 nM. This fluorescent aptasensor was successfully applied for kanamycin detection in complex samples, indicating its potential for food safety control and clinical research.
ANALYTICAL METHODS
(2023)
Review
Chemistry, Inorganic & Nuclear
Wanhe Wang, Jianhua Liu, Sang-Cuo Nao, Dik-Lung Ma, Jing Wang, Chung-Hang Leung
Summary: Changes in protein levels and types can indicate the occurrence of diseases, making differentially expressed proteins useful biomarkers for diagnosis and treatment. Luminescent iridium(III) complexes, especially affinity-based ones, with excellent optical properties, have gained attention in protein-based disease diagnostics. This review summarizes the current advances and future perspectives of affinity-based luminescent iridium(III) complexes for detecting disease-related proteins.
Article
Chemistry, Analytical
Xiaofei Liao, Nian Luo, Mengyan Li, Hao Fu, Li Zou
Summary: A novel label-free fluorescent biosensor for highly sensitive detection of bleomycin (BLM) was developed based on BLM-mediated inactivation of CRISPR-Cas12a and thioflavin T (ThT)-induced G-quadruplex formation. The biosensor exhibits high sensitivity and selectivity for detection of BLM in human serum samples, showing promise for BLM assay in biomedical research.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Mengyan Li, Nian Luo, Xiaofei Liao, Li Zou
Summary: We developed a dual signal amplification strategy for sensitive detection of circulating tumor DNA (ctDNA) based on hybridization chain reaction (HCR) and proximity hybridization-regulated CRISPR/Cas12a. This strategy exhibits high sensitivity toward ctDNA with a low detection limit of 5.43 fM, and it has been successfully applied for ctDNA detection in serum samples, showing great potential in the clinical diagnosis of cancer.
Article
Biochemical Research Methods
Ling Wang, Jingqi Liu, Feng Chen, Guodong Li, Jing Wang, Daniel Shiu-Hin Chan, Chun-Yuen Wong, Wanhe Wang, Chung-Hang Leung
Summary: Glutathione S-transferase (GST) is heterogeneously expressed in breast cancer cells and a highly selective probe 1 has been developed for imaging mitochondrial GST. This probe directly interacts with GST-pi, avoiding interference from nucleophilic species in the cellular environment. Probe 1 exhibits desirable photophysical properties and sensitive detection, enabling specific and quantitative visualization of breast cell lines.
BIOCONJUGATE CHEMISTRY
(2023)
Review
Biotechnology & Applied Microbiology
Jing Wang, Xifang Yang, Xueliang Wang, Wanhe Wang
Summary: CRISPR/Cas-based biosensors have been widely used for nucleic acid detection, but their applications for protein detection have been overlooked. Recent studies show that CRISPR/Cas-based biosensors not only analyze proteins, but also enhance the sensitivity and specificity of protein detection. However, there is a lack of comprehensive reviews and elucidation of the mechanisms of CRISPR/Cas-based biosensors for protein detection, which hinders the development of better protein biosensors.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Xiaofei Liao, Mengyan Li, Li Zou
Summary: A label-free and sensitive colorimetric sensing strategy for the detection of bleomycin (BLM) was developed based on the activation of G-quadruplex DNAzyme via DNA strand scission mediated by BLM. The strategy exhibits high sensitivity and selectivity for detecting BLM in human serum samples, showing promising potential for clinical applications.
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.
