Diruthenium(ii,iii) metallodrugs of ibuprofen and naproxen encapsulated in intravenously injectable polymer–lipid nanoparticles exhibit enhanced activity against breast and prostate cancer cells

Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks

(2017) Rui Xue Zhang et al.   Nanoscale

The development of RAPTA compounds for the treatment of tumors

(2016) Benjamin S. Murray et al.   COORDINATION CHEMISTRY REVIEWS

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Metal Complexes and Their Effect at the Cellular Level

(2016) Christina N. Banti et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery

(2016) Xiao Yu Wu   Expert Opinion on Drug Delivery

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Axially-modified paddlewheel diruthenium(II,III)-ibuprofenato metallodrugs and the influence of the structural modification on U87MG and A172 human glioma cell proliferation, apoptosis, mitosis and migration

(2016) Hanif-Ur-Rehman et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Polymer–lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin–mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor

(2016) Rui Xue Zhang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Design of Hybrid MnO2-Polymer-Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment

(2015) Claudia R. Gordijo et al.   ADVANCED FUNCTIONAL MATERIALS

Linking the future of anticancer metal-complexes to the therapy of tumour metastases

(2015) Alberta Bergamo et al.   CHEMICAL SOCIETY REVIEWS

Nanoparticle colloidal stability in cell culture media and impact on cellular interactions

(2015) Thomas L. Moore et al.   CHEMICAL SOCIETY REVIEWS

Self-assembly of myristic acid in the presence of choline hydroxide: Effect of molar ratio and temperature

(2015) Audrey Arnould et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Manganese oxide and docetaxel co-loaded fluorescent polymer nanoparticles for dual modal imaging and chemotherapy of breast cancer

(2015) Azhar Z. Abbasi et al.   JOURNAL OF CONTROLLED RELEASE

Spectroscopic studies on interactions of the tetrakis(acetato)chloridodiruthenium(II,III) complex and the Ru2(II,III)-NSAID-derived metallodrugs of ibuprofen and ketoprofen with human serum albumin

(2015) Rodrigo Luis Silva Ribeiro Santos et al.   JOURNAL OF COORDINATION CHEMISTRY

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Unusual Structural Features in the Lysozyme Derivative of the Tetrakis(acetato)chloridodiruthenium(II,III) Complex

(2014) Luigi Messori et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru2Cl(Ibp)4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo

(2014) Marcel Benadiba et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Synergistic Nanoparticulate Drug Combination Overcomes Multidrug Resistance, Increases Efficacy, and Reduces Cardiotoxicity in a Nonimmunocompromised Breast Tumor Model

(2014) Adam J. Shuhendler et al.   MOLECULAR PHARMACEUTICS

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

RGD-conjugated solid lipid nanoparticles inhibit adhesion and invasion of αvβ3 integrin-overexpressing breast cancer cells

(2014) Dan Shan et al.   Drug Delivery and Translational Research

Nanocarriers for delivery of platinum anticancer drugs

(2013) Hardeep S. Oberoi et al.   ADVANCED DRUG DELIVERY REVIEWS

NSAIDs Inhibit Tumorigenesis, but How?

(2013) Evrim Gurpinar et al.   CLINICAL CANCER RESEARCH

Kinetic and mechanistic studies on reactions of diruthenium(ii,iii) with biologically relevant reducing agents

(2013) Rodrigo Luis Silva Ribeiro Santos et al.   DALTON TRANSACTIONS

Nanoformulation Improves Activity of the (pre)Clinical Anticancer Ruthenium Complex KP1019

(2013) P. Heffeter et al.   Journal of Biomedical Nanotechnology

Secretion of intestinal goblet cells: A novel excretion pathway of nanoparticles

(2013) Baoquan Zhao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Deciphering the mechanisms of cellular uptake of engineered nanoparticles by accurate evaluation of internalization using imaging flow cytometry

(2013) Sandra Vranic et al.   Particle and Fibre Toxicology

Perspectives for Novel Mixed Diruthenium-Organic Drugs as Metallopharmaceuticals in Cancer Therapy

(2012) Denise de Oliveira Silva   Anti-Cancer Agents in Medicinal Chemistry

Doxorubicin and mitomycin C co-loaded polymer-lipid hybrid nanoparticles inhibit growth of sensitive and multidrug resistant human mammary tumor xenografts

(2012) Preethy Prasad et al.   CANCER LETTERS

Targeting and delivery of platinum-based anticancer drugs

(2012) Xiaoyong Wang et al.   CHEMICAL SOCIETY REVIEWS

Thermodynamics of Axial Substitution and Kinetics of Reactions with Amino Acids for the Paddlewheel Complex Tetrakis(acetato)chloridodiruthenium(II,III)

(2012) Rodrigo L. S. R. Santos et al.   INORGANIC CHEMISTRY

Synthesis and characterization of a diruthenium(II,III)–ketoprofen compound and study of the in vitro effects on CRC cells in comparison to the naproxen and ibuprofen derivatives

(2012) Rodrigo L.S.R. Santos et al.   POLYHEDRON

A Novel Solid Lipid Nanoparticle Formulation for Active Targeting to Tumor αvβ3Integrin Receptors Reveals Cyclic RGD as A Double-Edged Sword

(2012) Adam J. Shuhendler et al.   Advanced Healthcare Materials

A novel nanoparticle formulation overcomes multiple types of membrane efflux pumps in human breast cancer cells

(2012) Preethy Prasad et al.   Drug Delivery and Translational Research

Hybrid Quantum Dot−Fatty Ester Stealth Nanoparticles: Toward Clinically Relevant in Vivo Optical Imaging of Deep Tissue

(2011) Adam J. Shuhendler et al.   ACS Nano

Thermally-triggered ‘off–on–off’ response of gadolinium-hydrogel–lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry

(2011) Adam J. Shuhendler et al.   JOURNAL OF CONTROLLED RELEASE

Approaching tumour therapy beyond platinum drugs

(2011) A. Bergamo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Inhibition of C6 rat glioma proliferation by [Ru2Cl(Ibp)4] depends on changes in p21, p27, Bax/Bcl2 ratio and mitochondrial membrane potential

(2010) Marcel Benadiba et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A novel doxorubicin-mitomycin C co-encapsulated nanoparticle formulation exhibits anti-cancer synergy in multidrug resistant human breast cancer cells

(2009) Adam J. Shuhendler et al.   BREAST CANCER RESEARCH AND TREATMENT

The novel ruthenium—γ-linolenic complex [Ru2(aGLA)4Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased reactive oxygen species generation and apoptosisin vitro

(2009) Geise Ribeiro et al.   CELL BIOCHEMISTRY AND FUNCTION

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells

(2009) H. Hanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diruthenium(II,III) complexes of ibuprofen, aspirin, naproxen and indomethacin non-steroidal anti-inflammatory drugs: Synthesis, characterization and their effects on tumor-cell proliferation

(2008) Geise Ribeiro et al.   POLYHEDRON