Biodegradable nanocarriers for small interfering ribonucleic acid (siRNA) co-delivery strategy increase the chemosensitivity of pancreatic cancer cells to gemcitabine

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Biodegradable charged polyester-based vectors (BCPVs) as an efficient non-viral transfection nanoagent for gene knockdown of the BCR–ABL hybrid oncogene in a human chronic myeloid leukemia cell line

(2016) Chengbin Yang et al.   Nanoscale

Preclinical and clinical development of siRNA-based therapeutics

(2015) Gulnihal Ozcan et al.   ADVANCED DRUG DELIVERY REVIEWS

Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted siRNA Delivery to HER2+Breast Cancer

(2015) Worapol Ngamcherdtrakul et al.   ADVANCED FUNCTIONAL MATERIALS

Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer

(2015) Xiao Zhao et al.   BIOMATERIALS

Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery

(2015) Nan Zheng et al.   JOURNAL OF CONTROLLED RELEASE

Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles

(2015) Mark McCully et al.   Nano Research

15 years on siRNA delivery: Beyond the State-of-the-Art on inorganic nanoparticles for RNAi therapeutics

(2015) João Conde et al.   Nano Today

RNAi-based therapeutic nanostrategy: IL-8 gene silencing in pancreatic cancer cells using gold nanorods delivery vehicles

(2015) Nishtha Panwar et al.   NANOTECHNOLOGY

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Synthesis and Characterization of Mn:ZnSe/ZnS/ZnMnS Sandwiched QDs for Multimodal Imaging and Theranostic Applications

(2015) Yucheng Wang et al.   Small

A Light-Driven Therapy of Pancreatic Adenocarcinoma Using Gold Nanorods-Based Nanocarriers for Co-Delivery of Doxorubicin and siRNA

(2015) Feng Yin et al.   Theranostics

Biodegradable nanoparticle-mediated K-ras down regulation for pancreatic cancer gene therapy

(2015) Chengbin Yang et al.   Journal of Materials Chemistry B

Efficacy of gemcitabine conjugated and miRNA-205 complexed micelles for treatment of advanced pancreatic cancer

(2014) Anupama Mittal et al.   BIOMATERIALS

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Early Detection of Pancreatic Cancer: What Will It Take to Diagnose and Treat Curable Pancreatic Neoplasia?

(2014) A. M. Lennon et al.   CANCER RESEARCH

Aggregation-induced emission (AIE) dye loaded polymer nanoparticles for gene silencing in pancreatic cancer and their in vitro and in vivo biocompatibility evaluation

(2014) Rui Hu et al.   Nano Research

Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery

(2014) Li Li et al.   Nano Research

Pancreatic cancer gene therapy using an siRNA-functionalized single walled carbon nanotubes (SWNTs) nanoplex

(2014) Tommy Anderson et al.   Biomaterials Science

Interleukin-8 gene silencing on pancreatic cancer cells using biodegradable polymer nanoplexes

(2014) Guimiao Lin et al.   Biomaterials Science

Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer

(2013) Shinichi Yabuuchi et al.   CANCER LETTERS

Polymer gene delivery: overcoming the obstacles

(2013) Ahmed Aied et al.   DRUG DISCOVERY TODAY

Synthesis of Cationic Polylactides with Tunable Charge Densities as Nanocarriers for Effective Gene Delivery

(2013) Charles H. Jones et al.   MOLECULAR PHARMACEUTICS

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Biodegradable Nanocapsules as siRNA Carriers for Mutant K-Ras Gene Silencing of Human Pancreatic Carcinoma Cells

(2013) Guimiao Lin et al.   Small

Lipopolysaccharide enhances FcɛRI-mediated mast cell degranulation by increasing Ca2+entry through store-operated Ca2+channels: implications for lipopolysaccharide exacerbating allergic asthma

(2012) Chengbin Yang et al.   EXPERIMENTAL PHYSIOLOGY

Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice

(2012) Meredith A. Collins et al.   PLoS One

RETRACTED: Notch-1 induces epithelial–mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

(2011) Bin Bao et al.   CANCER LETTERS

Notch and Kras in pancreatic cancer: At the crossroads of mutation, differentiation and signaling

(2011) Jean-Paul De La O et al.   CELL CYCLE

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Delivery of siRNA Therapeutics: Barriers and Carriers

(2010) Jie Wang et al.   AAPS Journal

Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF

(2010) Shadan Ali et al.   CANCER RESEARCH

Promise and Challenge of RNA Interference–Based Therapy for Cancer

(2010) Fabio Petrocca et al.   JOURNAL OF CLINICAL ONCOLOGY

KRAS and BRAF: drug targets and predictive biomarkers

(2010) Efsevia Vakiani et al.   JOURNAL OF PATHOLOGY

Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells

(2009) Y. Li et al.   CANCER RESEARCH

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel

(2009) Changxing Liu et al.   JOURNAL OF CONTROLLED RELEASE

Epithelial-to-Mesenchymal Transition and Integrin-Linked Kinase Mediate Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Hepatoma Cells

(2008) B. C. Fuchs et al.   CANCER RESEARCH

Notch-1 associates with IKKα and regulates IKK activity in cervical cancer cells

(2008) L L Song et al.   ONCOGENE

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA