Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted siRNA Delivery to HER2+Breast Cancer

Trastuzumab emtansine: mechanisms of action and drug resistance

(2014) Mark Barok et al.   BREAST CANCER RESEARCH

Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target?

(2014) Hisataka Kobayashi et al.   Theranostics

Cyclodextrin and Polyethylenimine Functionalized Mesoporous Silica Nanoparticles for Delivery of siRNA Cancer Therapeutics

(2014) Jianliang Shen et al.   Theranostics

Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo

(2013) Huan Meng et al.   ACS Nano

Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery

(2013) Christian Argyo et al.   CHEMISTRY OF MATERIALS

A Targeted RNAi Screen of the Breast Cancer Genome Identifies KIF14 and TLN1 as Genes That Modulate Docetaxel Chemosensitivity in Triple-Negative Breast Cancer

(2013) S. M. Singel et al.   CLINICAL CANCER RESEARCH

Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro

(2013) R. Broering et al.   INTERNATIONAL IMMUNOLOGY

Independent versus Cooperative Binding in Polyethylenimine–DNA and Poly(l-lysine)–DNA Polyplexes

(2013) Tiia-Maaria Ketola et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Comparison of Thiolated and Disulfide-Crosslinked Polyethylenimine for Nonviral Gene Delivery

(2013) Latha Aravindan et al.   MACROMOLECULAR BIOSCIENCE

Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo

(2013) Daoshu Lin et al.   Nanoscale

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma

(2013) S. A. Jensen et al.   Science Translational Medicine

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

(2012) Fangqiong Tang et al.   ADVANCED MATERIALS

A mesoporous silica nanoparticle – PEI – Fusogenic peptide system for siRNA delivery in cancer therapy

(2012) Xu Li et al.   BIOMATERIALS

Coadministration of Epithelial Junction Opener JO-1 Improves the Efficacy and Safety of Chemotherapeutic Drugs

(2012) I. Beyer et al.   CLINICAL CANCER RESEARCH

Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization Laboratory

(2012) Rachael M. Crist et al.   Integrative Biology

Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles

(2012) Limin Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A genome-wide RNAi screen identifies novel targets of neratinib resistance leading to identification of potential drug resistant genetic markers

(2012) Attila A. Seyhan et al.   Molecular BioSystems

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane

(2012) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4

(2012) Y. Ren et al.   Science Translational Medicine

Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis

(2012) Y.-d. Yao et al.   Science Translational Medicine

The Business of RNAi Therapeutics in 2012

(2012) Dirk Haussecker   Molecular Therapy-Nucleic Acids

Strong EGFR signaling in cell line models of ERBB2-amplified breast cancer attenuates response towards ERBB2-targeting drugs

(2012) F Henjes et al.   Oncogenesis

Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells

(2011) Haiyuan Zhang et al.   ACS Nano

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Novel Cationic Lipids with Enhanced Gene Delivery and Antimicrobial Activity

(2010) D. E. Fein et al.   MOLECULAR PHARMACOLOGY

Controlled Extracellular Matrix Degradation in Breast Cancer Tumors Improves Therapy by Trastuzumab

(2010) Ines Beyer et al.   MOLECULAR THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Using Functional Genetics to Understand Breast Cancer Biology

(2010) A. Ashworth et al.   Cold Spring Harbor Perspectives in Biology

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Ferumoxytol: A New Intravenous Iron Preparation for the Treatment of Iron Deficiency Anemia in Patients with Chronic Kidney Disease

(2009) Michael H Schwenk   PHARMACOTHERAPY

How Location Governs Toll-Like Receptor Signaling

(2009) Akanksha Chaturvedi et al.   TRAFFIC

siRNA stabilization prolongs gene knockdown in primary T lymphocytes

(2008) Andrej Mantei et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Determinants of Cytokine Induction by Small Interfering RNA in Human Peripheral Blood Mononuclear Cells

(2008) Maryam Zamanian-Daryoush et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH