Biodegradable nanoparticle-mediated K-ras down regulation for pancreatic cancer gene therapy

Interleukin-8 gene silencing on pancreatic cancer cells using biodegradable polymer nanoplexes

(2014) Guimiao Lin et al.   Biomaterials Science

eEF1A2 promotes cell migration, invasion and metastasis in pancreatic cancer by upregulating MMP-9 expression through Akt activation

(2013) Chao Xu et al.   CLINICAL & EXPERIMENTAL METASTASIS

Targeting the RAS oncogene

(2013) Asami Takashima et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Synthesis of Cationic Polylactides with Tunable Charge Densities as Nanocarriers for Effective Gene Delivery

(2013) Charles H. Jones et al.   MOLECULAR PHARMACEUTICS

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Diversifying microRNA sequence and function

(2013) Stefan L. Ameres et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biodegradable Nanocapsules as siRNA Carriers for Mutant K-Ras Gene Silencing of Human Pancreatic Carcinoma Cells

(2013) Guimiao Lin et al.   Small

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Involvement of oncogenic K-ras on cell migration stimulated by lysophosphatidic acid receptor-2 in pancreatic cancer cells

(2012) Kyohei Yoshikawa et al.   EXPERIMENTAL CELL RESEARCH

Lipopolysaccharide enhances FcɛRI-mediated mast cell degranulation by increasing Ca2+entry through store-operated Ca2+channels: implications for lipopolysaccharide exacerbating allergic asthma

(2012) Chengbin Yang et al.   EXPERIMENTAL PHYSIOLOGY

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice

(2012) Meredith A. Collins et al.   PLoS One

Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

(2012) Chih-Kuang Chen et al.   Advanced Healthcare Materials

Special delivery: targeted therapy with small RNAs

(2011) D Peer et al.   GENE THERAPY

Delivery of siRNA Therapeutics: Barriers and Carriers

(2010) Jie Wang et al.   AAPS Journal

Targeting apoptosis pathways in pancreatic cancer

(2010) Alexander Arlt et al.   CANCER LETTERS

miR-146a Suppresses Invasion of Pancreatic Cancer Cells

(2010) Y. Li et al.   CANCER RESEARCH

Promise and Challenge of RNA Interference–Based Therapy for Cancer

(2010) Fabio Petrocca et al.   JOURNAL OF CLINICAL ONCOLOGY

Elimination Pathways of Systemically Delivered siRNA

(2010) Yuanyu Huang et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug

(2009) J. Guillermet-Guibert et al.   MOLECULAR CANCER THERAPEUTICS

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion

(2009) Ying-Hui Zhi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications

(2008) Chuan Huang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Novel Ras pathway inhibitor induces apoptosis and growth inhibition of K-ras-mutated cancer cells in vitro and in vivo

(2008) Piotr Jasinski et al.   Translational Research