Review
Biochemistry & Molecular Biology
Benita Wiatrak, Katarzyna Balon, Paulina Jawien, Dominika Bednarz, Izabela Jeskowiak, Adam Szelag
Summary: With the increase in life expectancy, the number of patients with dementia, including Alzheimer's disease (AD), is growing. This review focuses on the potential association of AD with the digestive system, particularly the gut microbiota. The role of diet quality in preventing and alleviating Alzheimer's disease is also discussed, as well as the treatment strategies for changing the microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Himanshi Yadav, Jaldhi, Rati Bhardwaj, Anamika, Amrita Bakshi, Suchi Gupta, Shashank Kumar Maurya
Summary: Emerging evidence suggests that gut microbiota plays a crucial role in regulating brain functions and maintaining brain homeostasis. Disturbed gut microbiota has been associated with various neurological diseases, while gut microbiome-derived exosomes have shown potential as therapeutic targets for neurodegenerative diseases. Pharmacological interventions, including antibiotics, prebiotics, and probiotics, can influence the management of neurological diseases mediated by the gut microbiome. However, further research is needed to enhance our understanding of the gut-brain connection and its implications for neurological diseases.
Article
Biochemical Research Methods
Heather Hulme, Lynsey M. Meikle, Nicole Strittmatter, John Swales, Gregory Hamm, Sheila L. Brown, Simon Milling, Andrew S. MacDonald, Richard J. A. Goodwin, Richard Burchmore, Daniel M. Wall
Summary: Microbes have significant effects on the levels of neurotransmitters and their precursors in the brain. Antibiotic treatment does not cause significant changes in these metabolites in the brain.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Review
Endocrinology & Metabolism
Elena Layunta, Berta Buey, Jose Emilio Mesonero, Eva Latorre
Summary: Disruption of the microbiota-gut-brain axis can lead to various pathologies affecting the brain and intestine. Serotonin is identified as a crucial mediator in the communication between microbiota, gut, and brain, playing a significant role in gastrointestinal and brain physiology. The intestinal microbiota also play a key role in serotonin signaling, highlighting the importance of serotonin as a mediator in microbiota-host interactions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Neurosciences
Gregory W. Kirschen, Snigdha Panda, Irina Burd
Summary: This review critically evaluates the current evidence on how early life infection affects neurodevelopment through the gut-brain axis. It discusses the detrimental effects of congenital infections on fetal/neonatal neurological development and highlights the potential role of the gut microbiome in long-term neurodevelopmental consequences. The review also addresses controversies surrounding placental sterility and the influence of antibiotic exposure during pregnancy.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
Minjia Chen, Guangcong Ruan, Lu Chen, Senhong Ying, Guanhu Li, Fenghua Xu, Zhifeng Xiao, Yuting Tian, Linling Lv, Yi Ping, Yi Cheng, Yanling Wei
Summary: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with unknown causes, and disruption in the gut-brain axis is believed to be the cause. Recent studies have shown that neurotransmitters play an important role in IBS, affecting blood flow regulation, intestinal motility, immune system, and gut microbiota. These studies have shed light on the mechanisms of neurotransmitters in the pathogenesis of IBS and provided new therapeutic strategies targeting the nervous system or microbiota.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Berkley Luck, Thomas D. Horvath, Kristen A. Engevik, Wenly Ruan, Sigmund J. Haidacher, Kathleen M. Hoch, Numan Oezguen, Jennifer K. Spinler, Anthony M. Haag, James Versalovic, Melinda A. Engevik
Summary: The study revealed that Bifidobacterium dentium has the capacity to produce the important neurotransmitter gamma-aminobutyric acid (GABA) and can impact neurotransmitter concentrations in vivo, indicating a potential role of B. dentium in neurotransmitter regulation.
Review
Oncology
Se-Young Park, Byeong-Oh Hwang, Mihwa Lim, Seung-Ho Ok, Sun-Kyoung Lee, Kyung-Soo Chun, Kwang-Kyun Park, Yinling Hu, Won-Yoon Chung, Na-Young Song
Summary: Microbiota dysbiosis is closely associated with various diseases in the human body, with the oral cavity and gut serving as the two major microbial habitats that play crucial roles in disease pathogenesis. Despite the well-segregated oral and gut microbiome profiles due to the oral-gut barrier, microbial transmissions between these two regions can shape and modulate the microbial ecosystem, ultimately influencing disease pathogenesis. Understanding the interplay of the oral-gut microbiome axis in disease development can offer insights for precise diagnosis, prognosis, and effective treatment strategies.
Review
Biochemistry & Molecular Biology
Kathryn G. Sterling, Griffin Kutler Dodd, Shatha Alhamdi, Peter G. Asimenios, Ruben K. Dagda, Kenny L. De Meirleir, Dorothy Hudig, Vincent C. Lombardi
Summary: Advances in NGS technologies have provided valuable insights into the gut microbiota composition and its potential impact on diseases. The mucosal immunity plays a significant role in shaping the microbiota and its alterations may affect neuroimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Tradite Neziraj, Lena Siewert, Elisabeth Possnecker, Anne-Katrin Probstel
Summary: This article summarizes the differentiation and functions of regulatory B cells (Bregs) and their involvement in neuroinflammatory diseases. The crosstalk between gut-originating Bregs and the gut microbiome is highlighted, and potential microbiota-regulatory B cell-targeted therapies in immune-mediated diseases are discussed.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Food Science & Technology
Brett J. Deters, Mir Saleem
Summary: Glutamine can positively impact gut health by supporting the gut microbiome, gut mucosal wall integrity, and modulating inflammatory responses. The gut-brain connection, modulated by the vagus nerve, can impact the brain's neurochemical environment, potentially influencing conditions such as depression. Supplementing with glutamine may offer adjunctive nutritional support in cases of depression by promoting proper gut health and function.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Review
Cell Biology
Yun Han Kwon, Waliul I. Khan
Summary: This review examines the interactions between serotonin and the gut microbiota, and discusses their importance for intestinal health. Recent studies have shown bidirectional interactions between the host serotonergic system and the gut microbiota, which may have implications for conditions such as inflammatory bowel disease.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Clinical Neurology
Yanlin Tao, Houyuan Zhou, Zikang Li, Hui Wu, Fanggeng Wu, Zhiguo Miao, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: The deletion of TGR5 in mice results in increased anxiety and depression-like behaviors, accompanied by reduced levels of 5-HT. Gut microbiota changes, characterized by alterations in microbial signatures, play a direct role in these behaviors and serotonin alterations. Fecal microbiota transplantation experiments further support the involvement of gut bacteria in mood regulation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Medicine, Research & Experimental
Liwei Wu, Jiao Feng, Jingjing Li, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai, Chuanyong Guo
Summary: Hepatocellular carcinoma is the most common primary liver malignancy with limited therapeutic options. Alterations in bile acids can affect hepatic metabolic balance and contribute to the pathogenesis of liver cancer. The gut microbiota plays a key role in promoting and developing liver cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Haoran Wang, Tingting Zhao, Zhenjiang Liu, Danzengquzhen, Cisangzhuoma, Jinying Ma, Xin Li, Xiaodan Huang, Bin Li
Summary: Recent investigations suggest that dietary consumption of flavonoids has neuroprotective effects by inhibiting neuroinflammatory and oxidative stress responses. Flavonoids may also shape gut microbiota composition and promote the growth of beneficial bacteria that produce neuroprotective metabolites. By influencing the microbiota-gut-brain axis, flavonoids indirectly improve brain health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mohammed A. A. Saleh, Elizabeth C. M. de Lange
Summary: This study investigated the impact of altered cerebral blood flow, tight junction paracellular pore radius, brain extracellular fluid volume, and pH values on drug transport and concentrations in the central nervous system. The results showed drug-dependent effects of pathophysiological changes on blood-brain barrier transport and drug concentrations within the brain extracellular and intracellular fluid. Changes in pore radius, pH values, and blood flow affected the rate and extent of drug transport, highlighting the importance of considering these factors in drug delivery to the brain.
Review
Hematology
Sanny Scheffer, Dorien M. A. Hermkens, Louise van der Weerd, Helga E. de Vries, Mat J. A. P. Daemen
Summary: Alzheimer's disease is characterized by neurodegeneration, neuroinflammation, and cognitive decline. Cardiovascular disease has been identified as an important contributor to the development and progression of AD, known as the vascular hypothesis. Vascular risk factors are associated with an increased chance of developing AD, with chronic cerebral hypoperfusion suggested to play a key role in disease onset.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wieke M. van Oostveen, Elizabeth C. M. de Lange
Summary: This review discusses the contemporary methods of early diagnosis and longitudinal monitoring of AD using imaging techniques, examining their diagnostic utility, benefits, and limitations. Additionally, it assesses novel techniques, applications, and biomarkers for AD research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Nienke M. de Wit, Kevin Mol, Sabela Rodriguez-Lorenzo, Helga E. de Vries, Gijs Kooij
Summary: Alzheimer's disease is the leading cause of dementia worldwide, characterized by extracellular amyloid deposition, neurofibrillary tangles, and chronic neuroinflammation. There is currently no cure for prevention of Alzheimer's disease, but manipulating bioactive lipid pathways may offer novel therapeutic approaches to resolve chronic neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Ynn van Olst, Carla Rodriguez-Mogeda, Carmen Picon, Svenja Kiljan, Rachel E. James, Alwin Kamermans, Susanne M. A. van der Pol, Lydian Knoop, Iliana Michailidou, Evelien Drost, Marc Franssen, Geert J. Schenk, Jeroen J. G. Geurts, Sandra Amor, Nicholas D. Mazarakis, Jack van Horssen, Helga E. de Vries, Richard Reynolds, Maarten E. Witte
Summary: The study identified two distinct microglial populations, MS1 and MS2, in the cortex of progressive MS patients, which differentially associate with neurodegeneration. Results suggest that microglia may initially protect neurons from meningeal inflammation-induced cell death by regulating synaptic location and phagocytosis, but over time, this protective property may be lost.
ACTA NEUROPATHOLOGICA
(2021)
Article
Immunology
Sanne G. S. Verberk, Hendrik J. P. van der Zande, Jeroen Baardman, Kyra E. de Goede, Karl J. Harber, Eelco D. Keuning, Joost M. Lambooij, Frank Otto, Anna Zawistowska-Deniziak, Helga E. de Vries, Menno P. J. de Winther, Bruno Guigas, Jan Van den Bossche
Summary: Research indicates that despite enhanced inflammatory responses in vitro, deficiency of macrophage Acly does not worsen acute and chronic inflammatory responses in vivo. Myeloid-specific Acly deletion has limited impact on inflammation and overall metabolic homeostasis in inflammatory disorders like multiple sclerosis and obesity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Wissam Beaino, Bieneke Janssen, Danielle J. Vugts, Helga E. de Vries, Albert D. Windhorst
Summary: There is increasing evidence showing the heterogeneity of microglia activation in neuroinflammatory and neurodegenerative diseases. Pro-inflammatory microglia are believed to be detrimental while anti-inflammatory microglia may aid in damage repair. PET imaging shows potential for non-invasive quantification of neuroinflammation and discrimination between microglia phenotypes, but obstacles remain in targeting specific markers for selective imaging.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Review
Immunology
Lynn van Olst, Sigrid J. M. Roks, Alwin Kamermans, Barbara J. H. Verhaar, Anne M. van der Geest, Majon Muller, Wiesje M. van der Flier, Helga E. de Vries
Summary: This review discusses the role of gut microbiota and their metabolites in influencing immunological changes in Alzheimer's disease. It highlights the potential of targeting gut microbiota to modulate inflammation as a promising future strategy in combating the progression of AD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Parand Zarekiani, Marjolein Breur, Nicole I. Wolf, Helga E. de Vries, Marjo S. van der Knaap, Marianna Bugiani
Summary: The blood-brain barrier in the brain is crucial for maintaining brain function in neurological disorders. Dysfunction of the neurovascular unit in leukodystrophies leads to endothelial dysfunction and astrocytic abnormalities. These findings enhance understanding of the pathophysiology of rare diseases.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
David Roig-Carles, Eduard Willms, Ruud D. Fontijn, Sarai Martinez-Pacheco, Imre Mager, Helga E. de Vries, Mark Hirst, Basil Sharrack, David K. Male, Cheryl A. Hawkes, Ignacio A. Romero
Summary: It has been discovered that small EVs released by inflamed brain endothelial cells may contribute to blood-brain barrier dysfunction, leading to cerebrovascular disorders. The expression of VCAM1 is associated with T-cell adhesion, while ICAM1 does not affect this process.
Review
Geriatrics & Gerontology
Antia Custodia, Alberto Ouro, Daniel Romaus-Sanjurjo, Juan Manuel Pias-Peleteiro, Helga E. de Vries, Jose Castillo, Tomas Sobrino
Summary: Alzheimer's disease is a neurodegenerative disease with a complex and unknown etiology. The two-hit vascular hypothesis suggests that brain vascular damage leads to the accumulation of beta-amyloid protein. Research has shown that endothelial progenitor cells play a significant role in understanding the disease etiology and developing potential therapies.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
I. A. Mulder, E. T. van Bavel, H. E. de Vries, J. M. Coutinho
Summary: This review provides an overview of compounds tested in clinical AIS trials and gives insight into which of these drugs warrant a re-evaluation as an add-on therapy for AIS in the era of EVT. Main trial outcomes and safety issues are summarized and promising compounds for re-evaluation are highlighted. Looking at group effect, drugs intervening with oxidative and nitrosative stress and neurogenesis/-regeneration and -recovery appear to have a favourable safety profile and show the most promising results regarding efficacy.
FLUIDS AND BARRIERS OF THE CNS
(2021)
Article
Biology
Sabela Rodriguez-Lorenzo, Lynn van Olst, Carla Rodriguez-Mogeda, Alwin Kamermans, Susanne M. A. van der Pol, Ernesto Rodriguez, Gijs Kooij, Helga E. de Vries
Summary: In this study, the immune landscape of periventricular brain regions in patients with MS was analyzed using single-cell mass cytometry (CyTOF). The results showed the accumulation of CD56(bright) NK cells in the brain regions of MS patients, bringing NK cells back into the spotlight of MS pathology.
Review
Neurosciences
Parand Zarekiani, Henrique Nogueira Pinto, Elly M. Hol, Marianna Bugiani, Helga E. de Vries
Summary: The neurovascular unit (NVU) is a highly organized multicellular system in the brain, consisting of neuronal, glial, and vascular cells. Dysfunctions of the NVU occur in various neurological disorders, but little is known about its function in leukodystrophies. Human induced pluripotent stem cells (hiPSC) offer a solution to overcome the limitations of studying leukodystrophies, providing a biologically relevant human context and preserving the patient's genetic background. This review focuses on the NVU function in leukodystrophies and the use of hiPSC-derived models to study neurovascular pathophysiology in these diseases.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Review
Biochemistry & Molecular Biology
Chunyuan Yin, Amy C. C. Harms, Thomas Hankemeier, Alida Kindt, Elizabeth C. M. de Lange
Summary: Alzheimer's disease is an aging-related neurodegenerative disease that leads to progressive memory loss and cognitive decline. Understanding the pathogenesis and etiology of the disease is still limited, and there are no effective treatments available. Metabolomics offers a valuable approach to studying biochemical changes and discovering potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)