Article
Immunology
Eric A. Woodcock, Ansel T. Hillmer, Christine M. Sandiego, Paul Maruff, Richard E. Carson, Kelly P. Cosgrove, Robert H. Pietrzak
Summary: This study found that LPS administration in healthy adults can impair memory processes, specifically affecting verbal learning and recall, hippocampal memory processes. Furthermore, LPS also leads to increased neuroinflammation, which is correlated with decreased performance in memory in the hippocampus, putamen, and thalamus. This experimental paradigm may be useful for investigating the mechanistic relationships between neuroinflammatory signaling and cognitive dysfunction in psychiatric and neurologic disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Cell Biology
Robert K. Doot, Anthony J. Young, Ilya M. Nasrallah, Reagan R. Wetherill, Andrew Siderowf, Robert H. Mach, Jacob G. Dubroff
Summary: Neuroinflammation is an important factor in neurodegenerative diseases and is mediated by microglia. This study used [F-18]NOS PET imaging to measure neuroinflammation in idiopathic Parkinson's disease patients and found increased oxidative stress as a marker of inflammation in early-stage disease.
Review
Neurosciences
Dominique Gouilly, Laure Saint-Aubert, Maria-Joao Ribeiro, Anne-Sophie Salabert, Clovis Tauber, Patrice Peran, Nicolas Arlicot, Jeremie Pariente, Pierre Payoux
Summary: This review provides an update on the results from 2018 and advances the characterization of TSPO imaging in Alzheimer's disease (AD) by re-examining TSPO function and expression. Although the biological basis of the TSPO PET signal is clearly related to microglia and astrocytes in AD, the exact process remains uncertain and may not be directly associated with neuroinflammation. Further studies are needed to explore the cellular significance underlying variations in the PET signal in AD.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Immunology
Rong Zhou, Bin Ji, Yanyan Kong, Limei Qin, Wuwei Ren, Yihui Guan, Ruiqing Ni
Summary: Neuroinflammation plays a significant role in the pathogenesis of Alzheimer's disease, and molecular imaging techniques have provided valuable insights into its involvement in disease progression. The development of new generation translocator protein tracers and other imaging technologies offers promise for monitoring disease progression and identifying potential targets for future research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Xiaoli Liao, Miao Chen, Yamin Li
Summary: The present study aimed to review evidence from postmortem brain and PET studies on the role of glia induced neuroinflammation in the pathogenesis of ASD. The findings from postmortem studies showed increased microglial number and density, as well as increased GFAP protein and mRNA expression in ASD subjects. However, the outcomes of PET studies were inconsistent, with one reporting increased TSPO expression and two reporting decreased TSPO expression in ASD subjects.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amanda J. Boyle, Emily Murrell, Junchao Tong, Christin Schifani, Andrea Narvaez, Melinda Wuest, Frederick West, Frank Wuest, Neil Vasdev
Summary: This study demonstrates the potential of using fluorine-18 labeled 6-fluoro-6-deoxy-D-fructose (6-[F-18]FDF) as a PET radiotracer to image microglial GLUT5 density in the brain following neuroinflammatory insult. The uptake of 6-[F-18]FDF in the ipsilateral striatum of LPS-injected rats was significantly higher compared to the contralateral striatum, while [F-18]FDG showed highest uptake at one week post-LPS injection. Immunohistochemistry confirmed the activation of microglia and astrocytes in the ipsilateral striatum. This proof-of-concept study highlights the early response of 6-[F-18]FDF to neuroinflammatory stimuli and its potential applications in neuroinflammatory and neurodegenerative diseases.
Review
Biochemistry & Molecular Biology
Aijun Ji, Jinbin Xu
Summary: NP is a common accompanying symptom of many diseases, seriously affecting the quality of life of patients. Neuron-microglia interaction has been found by experts to play a vital role in the occurrence and development of NP. Advanced studies and interventions using pharmaceuticals and traditional herbal medicines extracts have been attempted to address NP due to its unsatisfactory clinical treatments.
Review
Cell Biology
Menbere Y. Wendimu, Shelley B. Hooks
Summary: Neuroinflammation plays a fundamental role in neurodegenerative diseases, and microglia, as the immune guardians of the central nervous system, are central drivers of this inflammation. Microglia exhibit complex and often contradictory activation patterns in different pathological states, playing both detrimental and protective roles.
Article
Immunology
Kuriko Kagitani-Shimono, Hiroki Kato, Ryoko Kuwayama, Koji Tominaga, Shin Nabatame, Haruhiko Kishima, Jun Hatazawa, Masako Taniike
Summary: Neuroinflammation, visualized using translocator protein positron emission tomography with [C-11] DPA713, was found to be sensitive in identifying epileptic foci in child-onset focal epilepsy. The inflammation was implicated in the pathophysiology of epileptic foci caused by various etiologies, indicating a need for further research in diagnostic tools for identifying focal epileptogenic zones.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Sonia Lavisse, Sebastien Goutal, Catriona Wimberley, Matteo Tonietto, Michel Bottlaender, Philippe Gervais, Bertrand Kuhnast, Marie-Anne Peyronneau, Olivier Barret, Julien Lagarde, Marie Sarazin, Philippe Hantraye, Claire Thiriez, Philippe Remy
Summary: The study found significantly higher [F-18]-DPA714 binding in the midbrain, frontal cortex, and contralateral putamen of PD patients compared to healthy controls. Microglial activation in these regions did not correlate with motor symptoms severity or disease duration, but there was a trend towards correlation with disease duration in the cortex. This suggests a specific topographic pattern of microglial activation in PD patients.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Chemistry, Medicinal
Hyeokjin Lee, Ji-Hun Park, Hyunjung Kim, Sang-keun Woo, Joon Young Choi, Kyung-Han Lee, Yearn Seong Choe
Summary: In this study, a new radioligand was developed for neuroinflammation imaging targeting CSF1R with good binding affinity and specificity. The dynamic PET/CT images showed higher uptake in the LPS-treated mouse brain. Biodistribution study demonstrated increased brain uptake in LPS mice and inhibition of uptake in LPS mice pretreated with CPPC, indicating specificity of the radioligand for CSF1R.
Article
Biochemistry & Molecular Biology
Berend van der Wildt, Bieneke Janssen, Aleksandra Pekosak, E. Johanna L. Steen, Robert C. Schuit, Esther J. M. Kooijman, Wissam Beaino, Danielle J. Vugts, Albert D. Windhorst
Summary: Three P2Y(12)R PET tracers were evaluated for targeting in the brain, showing low brain uptake in healthy rats. Future efforts will focus on designing P2Y(12)R inhibitors with improved physicochemical characteristics to enhance brain penetration by reducing efflux transport.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Yunting Zhu, Maree J. Webster, Caitlin E. Murphy, Frank A. Middleton, Paul T. Massa, Chunyu Liu, Rujia Dai, Cyndi Shannon Weickert
Summary: Quiescent microglia and increased pro-inflammatory macrophages co-exist in the cortex of people with schizophrenia.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Nityanand Jain, Marks Smirnovs, Samanta Strojeva, Modra Murovska, Sandra Skuja
Summary: Chronic alcoholism and HHV-6 infection have been shown to promote neuroinflammation, especially in the Substantia Nigra (SN) region, resulting in significant changes in microglial functions and morphology. Alcoholics exhibit more inflammatory microglial changes and an increase in Iba1 expression, while HHV-6 infection exacerbates these effects. This highlights the compounding relationship between alcoholism and HHV-6 infection in promoting microglia-mediated neuroinflammation.
Article
Multidisciplinary Sciences
Camila Fernandez Zapata, Ginevra Giacomello, Eike J. Spruth, Jinte Middeldorp, Gerardina Gallaccio, Adeline Dehlinger, Claudia Dames, Julia K. H. Leman, Roland E. van Dijk, Andreas Meisel, Stephan Schlickeiser, Desiree Kunkel, Elly M. Hol, Friedemann Paul, Maria Kristina Parr, Josef Priller, Chotima Boettcher
Summary: Myeloid cells play an important role in Alzheimer's disease (AD), but their phenotypic and functional changes across different body compartments and their use as biomarkers in AD are still unclear. This study characterizes immune cells from peripheral blood, cerebrospinal fluid, choroid plexus, and brain parenchyma, revealing that AD-myeloid cells show more pronounced changes in phenotype in the choroid plexus and brain parenchyma. These findings highlight the importance of myeloid cells in AD and provide insights for future studies on biomarker assessment.
NATURE COMMUNICATIONS
(2022)
Correction
Biochemistry & Molecular Biology
Berend van der Wildt, Bieneke Janssen, Aleksandra Pekosak, E. Johanna L. Steen, Robert C. Schuit, Esther J. M. Kooijman, Wissam Beaino, Danielle J. Vugts, Albert D. Windhorst
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Denise Visser, Sander C. J. Verfaillie, Emma E. Wolters, Emma M. Coomans, Tessa Timmers, Hayel Tuncel, Ronald Boellaard, Sandeep S. V. Golla, Albert D. Windhorst, Philip Scheltens, Wiesje M. van der Flier, Bart N. M. van Berckel, Rik Ossenkoppele
Summary: Compared to LOAD, EOAD patients exhibit higher tau pathology levels but lower relative cerebral blood flow values, particularly in the medial temporal regions. The associations between lateral temporal and occipitoparietal tau pathology and relative cerebral blood flow with cognitive impairment are stronger in EOAD than in LOAD, suggesting different mechanisms underlying cognitive deficits in the two subtypes of Alzheimer's disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Geriatrics & Gerontology
Antia Custodia, Alberto Ouro, Daniel Romaus-Sanjurjo, Juan Manuel Pias-Peleteiro, Helga E. de Vries, Jose Castillo, Tomas Sobrino
Summary: Alzheimer's disease is a neurodegenerative disease with a complex and unknown etiology. The two-hit vascular hypothesis suggests that brain vascular damage leads to the accumulation of beta-amyloid protein. Research has shown that endothelial progenitor cells play a significant role in understanding the disease etiology and developing potential therapies.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hayel Tuncel, Ronald Boellaard, Emma M. Coomans, Marijke den Hollander-Meeuwsen, Erik F. J. de Vries, Andor W. J. M. Glaudemans, Paula Kopschina Feltes, David Vallez Garcia, Sander C. J. Verfaillie, Emma E. Wolters, Steven P. Sweeney, J. Michael Ryan, Magnus Ivarsson, Berkley A. Lynch, Patrick Schober, Philip Scheltens, Robert C. Schuit, Albert D. Windhorst, Peter P. De Deyn, Bart N. M. van Berckel, Sandeep S. Golla
Summary: This study evaluated the quantitative accuracy and test-retest repeatability of various parametric quantitative methods for dynamic [C-11]UCB-J PET in AD patients and healthy controls.
Review
Immunology
Maarten M. Steinz, Aiarpi Ezdoglian, Fatemeh Khodadust, Carla F. M. Molthoff, Madduri Srinivasarao, Philip S. Low, Gerben J. C. Zwezerijnen, Maqsood Yaqub, Wissam Beaino, Albert D. Windhorst, Sander W. Tas, Gerrit Jansen, Conny J. van der Laken
Summary: Non-invasive imaging modalities, particularly macrophage imaging with folate-based PET tracers, hold great promise in diagnostic and therapy response monitoring of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Cristina Barca, Christoph M. Griessinger, Andreas Faust, Dominic Depke, Markus Essler, Albert D. Windhorst, Nick Devoogdt, Kevin M. Brindle, Michael Schaefers, Bastian Zinnhardt, Andreas H. Jacobs
Summary: Radioligand theranostics in oncology utilize cancer-type specific biomarkers and molecular imaging for patient diagnosis, therapy, and personalized management. The concept has evolved with the development of theranostic pairs and the combination of nuclear medicine with different types of cancer therapies. The clinical applications of different theranostic radiopharmaceuticals in managing different tumor types support the combination of innovative oncological therapies such as gene and cell-based therapies with RT.
Article
Biology
Sabela Rodriguez-Lorenzo, Lynn van Olst, Carla Rodriguez-Mogeda, Alwin Kamermans, Susanne M. A. van der Pol, Ernesto Rodriguez, Gijs Kooij, Helga E. de Vries
Summary: In this study, the immune landscape of periventricular brain regions in patients with MS was analyzed using single-cell mass cytometry (CyTOF). The results showed the accumulation of CD56(bright) NK cells in the brain regions of MS patients, bringing NK cells back into the spotlight of MS pathology.
Review
Neurosciences
Parand Zarekiani, Henrique Nogueira Pinto, Elly M. Hol, Marianna Bugiani, Helga E. de Vries
Summary: The neurovascular unit (NVU) is a highly organized multicellular system in the brain, consisting of neuronal, glial, and vascular cells. Dysfunctions of the NVU occur in various neurological disorders, but little is known about its function in leukodystrophies. Human induced pluripotent stem cells (hiPSC) offer a solution to overcome the limitations of studying leukodystrophies, providing a biologically relevant human context and preserving the patient's genetic background. This review focuses on the NVU function in leukodystrophies and the use of hiPSC-derived models to study neurovascular pathophysiology in these diseases.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Review
Chemistry, Medicinal
Antonia Hognasbacka, Alex J. Poot, Danielle J. Vugts, Guus A. M. S. van Dongen, Albert D. Windhorst
Summary: This review analyzes the historical development of in vivo evaluation approaches for EGFR PET tracers and discusses the challenges faced by each tracer, as well as the requirements for driving progress in this field.
Article
Biology
Kikkie Poels, Maxime Schreurs, Matthijs Jansen, Danielle J. Vugts, Tom T. P. Seijkens, Guus A. M. S. van Dongen, Esther Lutgens, Wissam Beaino
Summary: This study investigates the feasibility of using PET/CT with an anti-CD40 monoclonal antibody to detect plaques in a mouse model of atherosclerosis. The results show that CD40 can be detected using a Zirconium-89 labeled antibody, making it a potential marker for plaque inflammation and vulnerability.
Article
Oncology
Floris A. Vuijk, Fleur Kleiburg, Wyanne A. Noortman, Linda Heijmen, Shirin Feshtali Shahbazi, Floris H. P. van Velden, Victor M. Baart, Shadhvi S. Bhairosingh, Bert D. Windhorst, Lukas J. A. C. Hawinkels, Petra Dibbets-Schneider, Neanke Bouwman, Stijn A. L. P. Crobach, Arantza Farina-Sarasqueta, Andreas W. K. S. Marinelli, Daniela E. Oprea-Lager, Rutger-Jan Swijnenburg, Frits Smit, Alexander L. Vahrmeijer, Lioe-Fee De Geus-Oei, Denise E. Hilling, Marije Slingerland
Summary: PSMA-targeted PET/CT imaging shows potential in detecting gastrointestinal cancers, but challenges include low tumor expression and high physiological uptake in surrounding organs/tissues. Additionally, [F-18]FDG PET/CT may be more effective in detecting colon, gastric, and pancreatic cancers compared to [F-18]DCFPyL PET/CT.
Review
Biochemistry & Molecular Biology
Chunyuan Yin, Amy C. C. Harms, Thomas Hankemeier, Alida Kindt, Elizabeth C. M. de Lange
Summary: Alzheimer's disease is an aging-related neurodegenerative disease that leads to progressive memory loss and cognitive decline. Understanding the pathogenesis and etiology of the disease is still limited, and there are no effective treatments available. Metabolomics offers a valuable approach to studying biochemical changes and discovering potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
E. Johanna L. Steen, A. Yeong Park, Wissam Beaino, Changdev Gorakshnath Gadhe, Esther Kooijman, Robert C. Schuit, Maxime Schreurs, Prisca Leferink, Jeroen J. M. Hoozemans, Jae Eun Kim, Jinhwa Lee, Albert D. Windhorst
Summary: This paper reports the development of a positron emission tomography (PET) tracer for potential therapeutic strategy against Parkinson's disease (PD). The tracer shows promising neuroprotective effects and can be used to target c-Abl, a harmful enzyme involved in PD.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Berend van der Wildt, E. Johanna Steen, Bieneke Janssen, Esther Kooijman, Maxime Schreurs, Danielle Vugts, Albert Windhorst
NUCLEAR MEDICINE AND BIOLOGY
(2022)