Article
Fisheries
Fangyuan Zhou, Lianlian Sun, Yina Shao, Xiumei Zhang, Chenghua Li
Summary: Glutaminolysis plays an important role in the immune response in Apostichopus japonicus. Decreased levels of glutaminolysis metabolic substrates and products were observed, accompanied by an increase in glutathione. The key genes in glutaminolysis were upregulated in response to pathogen infection. AMPK beta can regulate glutaminolysis by influencing the uptake of glutamine. Silencing AjAMPK beta leads to increased levels of glutamine and glutamate, decreased production of glutathione, and a reduction in redox homeostasis indexes.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Kirsti Hornigold, Julia Y. Chu, Stephen A. Chetwynd, Polly A. Machin, Laraine Crossland, Chiara Pantarelli, Karen E. Anderson, Phillip T. Hawkins, Anne Segonds-Pichon, David Oxley, Heidi C. E. Welch
Summary: Host defense against bacterial and fungal infections diminishes with age, particularly due to impaired neutrophil responses. Neutrophil function in old mice shows reduced capacity to clear pathogenic bacteria, with major responses declining except for normal chemotaxis, particularly upon LPS priming. This study confirms that mice are a suitable model for understanding the decline in human neutrophil function with age.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Hee Sun Byun, Eunjin Ju, Kyeong Ah Park, Kyung-Cheol Sohn, Chan Seok Jung, Jang Hee Hong, Hyunju Ro, Hoi Young Lee, Khong Trong Quan, InWha Park, MinKyun Na, Gang Min Hur
Summary: This study identified a compound (Ru-B) purified from Rubia philippinesis, which can induce apoptosis in multiple types of cancer cells by activating RIPK1-dependent cell death and producing reactive oxygen species. This compound is considered to have potential as a novel necroptosis-targeting compound in apoptosis-resistant colorectal cancer.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Immunology
Benyu Liu, Nian Liu, Xiaoxiao Zhu, Liuliu Yang, Buqing Ye, Huimu Li, Pingping Zhu, Tiankun Lu, Yong Tian, Zusen Fan
Summary: The newly identified circular RNA circZbtb20 is crucial for the maintenance and function of group 3 innate lymphoid cells (ILC3), with its deletion causing reduced ILC3 numbers and increased susceptibility to bacterial infections. The circZbtb20 enhances the stability of specific mRNA and initiates a signaling pathway to maintain the homeostasis of ILC3.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Anna Park, Kwang-eun Kim, Isaac Park, Sang Heon Lee, Kun-Young Park, Minkyo Jung, Xiaoxu Li, Maroun Bou Sleiman, Su Jeong Lee, Dae-Soo Kim, Jaehoon Kim, Dae-Sik Lim, Eui-Jeon Woo, Eun Woo Lee, Baek Soo Han, Kyoung-Jin Oh, Sang Chul Lee, Johan Auwerx, Ji Young Mun, Hyun-Woo Rhee, Won Kon Kim, Kwang-Hee Bae, Jae Myoung Suh
Summary: LETMD1 is a mitochondrial matrix protein that is crucial for maintaining respiratory function and thermogenesis in brown adipose tissue (BAT) upon cold stimulus. Knockout of LETMD1 leads to deficiency in OXPHOS complex proteins and impaired mitochondrial respiration in BAT. BAT-specific Letmd1 deficient mice exhibit the same phenotypes as Letmd1 knockout mice.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Nathalie Tisch, Carolin Mogler, Ana Stojanovic, Robert Luck, Emilia A. Korhonen, Alexander Ellerkmann, Heike Adler, Mahak Singhal, Geza Schermann, Lena Erkert, Jay Patankar, Andromachi Karakatsani, Anna-Lena Scherr, Yaron Fuchs, Adelheid Cerwenka, Stefan Wirtz, Bruno Christian Koehler, Hellmut G. Augustin, Christoph Becker, Thomas Schmidt, Carmen Ruiz de Almodovar
Summary: This study identifies Caspase-8 as a crucial factor in maintaining vascular homeostasis in the small intestine, and its deletion leads to hemorrhages and inflammation. Furthermore, Caspase-8 appears to be particularly important in lymphatic endothelial cells for maintaining gut homeostasis. The findings highlight the active role of endothelial cell dysfunction in driving chronic small intestinal inflammation and emphasize the importance of the intestinal vasculature in safeguarding organ function.
EMBO MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Dongning Li, Chengzhu Song, Jie Zhang, Xiaoyan Zhao
Summary: The study investigated whether ferroptosis played a role in 5-FU-induced cardiotoxicity. The results showed that ROS and iron homeostasis dependent ferroptosis played a vital role in the cardiotoxicity induced by 5-FU.
Article
Multidisciplinary Sciences
Susan MacLauchlan, Priyanka Kushwaha, Albert Tai, Sijia Chen, Catherine Manning, Gaurav Swarnkar, Yousef Abu-Amer, Katherine A. Fitzgerald, Shruti Sharma, Ellen M. Gravallese
Summary: Stimulator of interferon genes (STING) mediates interferon signaling and plays a crucial role in regulating homeostatic processes, including osteoclast differentiation and bone homeostasis. STING prevents trabecular bone loss in mice and influences osteoclast precursor differentiation through the regulation of interferon-stimulated genes (ISGs). These findings provide evidence for the important role of STING pathway in bone homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Sjoerd van der Post, George M. H. Birchenough, Jason M. Held
Summary: The proliferation of colonic stem cells (CSCs) is mediated by redox-dependent activation of epidermal growth factor receptor (EGFR) signaling via NADPH oxidase 1 (NOX1). NOX1 expression is CSC-specific and regulated by Toll-like receptor activation in response to the microbiota, linking CSC proliferation with the presence of bacterial components in the crypt.
Article
Biotechnology & Applied Microbiology
Se-Hyun Oh, Ji-Sun Ahn, Eun-Joo Oh, You-Jin Kim, Ju-Min Yook, Jeong-Hoon Lim, Hee-Yeon Jung, Ji-Young Choi, Chan-Duck Kim, Sun-Hee Park, Yong-Lim Kim, Jang-Hee Cho
Summary: The lethal intraperitoneal injection dose of ML171 for both males and females is 500 mg/kg. No mortality was observed for lower doses of ML171. The safe dose of single intraperitoneal ML171 in ICR mice was 250 mg/kg or less. Further studies are needed to confirm the safety of ML171 in the human body.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Liangkui Li, Haoyu Zhou, Jinhui Wang, Jiaxin Li, Xuchao Lyu, Wenshan Wang, Chengting Luo, He Huang, Dawang Zhou, Xiaowei Chen, Li Xu, Peng Li
Summary: This study reveals that the liver functions as an energy conversion center to maintain blood glucose homeostasis in neonates. Glucose is found to be the universal fuel essential for neonatal life. The limitation of lipid supply in milk leads to severe hypoglycemia and neonatal lethality.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Food Science & Technology
Myeong Joon Lee, Yeonoh Cho, Yujin Hwang, Youngheun Jo, Yeon-Gu Kim, Seung Hwan Lee, Jong Hun Lee
Summary: This study demonstrated that kaempferol can protect against mitochondrial damage and reduce the production of mitochondrial ROS in LPS-induced prostate organoids.
Article
Anesthesiology
Kali Hankerd, Ho Koo, Kathleen E. McDonough, Jigong Wang, Ramesh Pariyar, Shao-Jun Tang, Jin Mo Chung, Jun-Ho La
Summary: This study found that gonadal hormones are critical for the development and maintenance of peripherally maintained nociplastic pain state in females. Estradiol reconstitution before injury and post-injury stimulation can restore the development of this pain state, while G protein-coupled estrogen receptor antagonism can alleviate the pain. AITC-responsive afferents contribute to the maintenance of nociplastic mechanical hypersensitivity in females.
Article
Agronomy
Xuejiao Zhang, Xiaoyuan Zheng, Ye Han, Ruirui Yang, Qihui Wang, Di Gong, Yongcai Li, Dov Prusky, Yang Bi
Summary: Ultraviolet-C (UV-C) can maintain cell membrane integrity at potato tubers wounds during healing by regulating ROS homeostasis and increasing antioxidant activity.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wietse In het Panhuis, Milena Schoenke, Ricky Siebeler, Dorien Banen, Amanda C. M. Pronk, Trea C. M. Streefland, Salwa Afkir, Hetty C. M. Sips, Jan Kroon, Patrick C. N. Rensen, Sander Kooijman
Summary: Circadian disruption affects glucose and lipid metabolism with sex-specific effects. This study demonstrates that circadian disruption has sex-dependent effects on glucose metabolism, aggravated by male sex hormones and partially rescued by female sex hormones.
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Schwenck, Roman Mehling, Wolfgang M. Thaiss, Daniela Kramer, Irene Gonzalez Menendez, Hasan Halit Oez, Dominik Hartl, Klaus Schulze-Osthoff, Stephan Hailfinger, Kamran Ghoreschi, Leticia Quintanilla-Martinez, Harald Carlsen, Martin Roecken, Bernd J. Pichler, Manfred Kneilling
MOLECULAR IMAGING AND BIOLOGY
(2020)
Article
Immunology
Katarzyna Kuczkowska, Lise Overland, Sergio D. C. Rocha, Vincent G. H. Eijsink, Geir Mathiesen
Article
Biotechnology & Applied Microbiology
Ingvild S. Reinseth, Kirill Ovchinnikov, Hanne H. Tonnesen, Harald Carlsen, Dzung B. Diep
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2020)
Article
Immunology
Matthew J. Frank, Michael S. Khodadoust, Debra K. Czerwinski, Ole A. W. Haabeth, Michael P. Chu, David B. Miklos, Ranjana H. Advani, Ash A. Alizadeh, Neel K. Gupta, Lauren S. Maeda, Sunil A. Reddy, Ginna G. Laport, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Wen-Kai Weng, Kevin Sheehan, Malek Faham, Ami Okada, A. Holliston Moore, Destiny L. Phillips, Irene L. Wapnir, Joshua D. Brody, Ronald Levy
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Hematology
Ole Audun W. Haabeth, Kjartan Hennig, Marte Fauskanger, Geir Age Loset, Bjarne Bogen, Anders Tveita
Article
Hematology
Aaron J. Wilk, Nancy Lynn-Benner Weidenbacher, Rosemary Vergara, Ole A. W. Haabeth, Ronald Levy, Robert M. Waymouth, Paul A. Wender, Catherine A. Blish
Article
Chemistry, Multidisciplinary
Ole A. W. Haabeth, Julian J. K. Lohmeyer, Adrienne Sallets, Timothy R. Blake, Idit Sagiv-Barfi, Debra K. Czerwinski, Blaine McCarthy, Abigail E. Powell, Paul A. Wender, Robert M. Waymouth, Ronald Levy
Summary: The success of two FDA-approved mRNA vaccines in combating the SARS-CoV-2 pandemic has demonstrated the speed and therapeutic potential of mRNA vaccines. To ensure flexibility in future vaccine development, different vaccination strategies and alternative mRNA delivery vehicles are desirable.
ACS CENTRAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Dimitrios Papoutsis, Sergio Domingos Cardoso da Rocha, Anne Mari Herfindal, Siv Kjolsrud Bohn, Harald Carlsen
Summary: In this study, the effects of a Western diet (WD) and a low-fat diet (LFD) on colonic health in a DSS-induced inflammation mouse model were compared. The results showed that mice fed a WD were protected against DSS-induced colonic inflammation compared to those fed an LFD.
JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Stefano Testa, Ole A. W. Haabeth, Timothy R. Blake, Trevor J. Del Castillo, Debra K. Czerwinski, Ranjani Rajapaksa, Paul A. Wender, Robert M. Waymouth, Ronald Levy
Summary: Charge-altering releasable transporters (CARTs) containing fingolimod were synthesized to enhance mRNA delivery and expression in lymphocytes through ligand-receptor interaction. The fingolimod-conjugated CARTs showed superior transfection of activated T and B lymphocytes in vitro and increased mRNA delivery to specific cell populations in the spleen in vivo.
Article
Biochemistry & Molecular Biology
Anne Mari Herfindal, Sergio Domingos Cardoso Rocha, Dimitrios Papoutsis, Siv Kjolsrud Bohn, Harald Carlsena
Summary: NOX1 plays a significant role in ROS/RNS production in the colon and modulation of the colonic microbiota.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Dimitrios Papoutsis, Sergio Domingos Cardoso Rocha, Anne Mari Herfindal, Siv Kjolsrud Bohn, Harald Carlsen
Summary: In a low-grade inflammation model, replacement of protein and/or fiber in a Western diet with faba bean fractions had marginal effects on inflammatory parameters and colonic microbiota.
Article
Immunology
Sergio Domingos Cardoso Rocha, Peng Lei, Byron Morales-Lange, Liv Torunn Mydland, Margareth Overland
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Jeleel O. Agboola, Sergio D. C. Rocha, Dominic D. Mensah, Jon O. Hansen, Ove Oyas, David Lapena, Liv T. Mydland, Magnus O. Arntzen, Svein J. Horn, Margareth Overland
Summary: This study investigates the effects of yeast and processing on the gut microbiota of Atlantic salmon fed a soybean meal-based diet. The results show that the inclusion of soybean meal in the diet alters the composition and predicted metabolic capacity of the fish's gut microbiota, while the addition of different processed yeasts does not change these effects.
Article
Agriculture, Dairy & Animal Science
Khaled Itani, Caroline Marcussen, Sergio D. C. Rocha, Purushothaman Kathiresan, Liv Torunn Mydland, Charles McLean Press, Zhuqing Xie, Anne-Helene Tauson, Margareth Overland
Summary: This study evaluated the effect of dietary graded levels of Cyberlindnera jadinii yeast on the growth performance, nutrient digestibility, and gut health of broilers. The results showed that C. jadinii yeast can supply up to 20% of dietary protein without negatively affecting broiler performance. Additionally, higher levels of C. jadinii inclusion increased the relative abundance of lactobacillus in the intestines.
Article
Microbiology
Pabodha Weththasinghe, Sergio D. C. Rocha, Ove Oyas, Leidy Lagos, Jon O. Hansen, Liv T. Mydland, Margareth Overland
Summary: This study reveals that the addition of insect meals and fractions to the diet of Atlantic salmon can alter the composition and metabolic capacity of the fish's gut microbiota. The use of full-fat black soldier fly larvae meal appears to have a more beneficial modulatory effect on the gut microbiota than larvae processed by separating the lipid or exoskeleton fractions.