NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation

Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation

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Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome

(2019) Jason M. Held   ANTIOXIDANTS & REDOX SIGNALING

NADPH oxidases and ROS signaling in the gastrointestinal tract

(2018) Gabriella Aviello et al.   Mucosal Immunology

NoxO1 Controls Proliferation of Colon Epithelial Cells

(2018) Franziska Moll et al.   Frontiers in Immunology

Tales from the crypt: new insights into intestinal stem cells

(2018) Helmuth Gehart et al.   Nature Reviews Gastroenterology & Hepatology

Redox signaling mediated by the gut microbiota

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Redox signaling in the gastrointestinal tract

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NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

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The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

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Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection

(2016) Gratiela Pircalabioru et al.   Cell Host & Microbe

Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium

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The ROS-generating oxidase Nox1 is required for epithelial restitution following colitis

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The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling

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NADPH oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice

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Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine

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Global, in situ, site-specific analysis of protein S-sulfenylation

(2015) Jing Yang et al.   Nature Protocols

Gut biogeography of the bacterial microbiota

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Unraveling intestinal stem cell behavior with models of crypt dynamics

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The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium

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ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

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Symbiotic lactobacilli stimulate gut epithelial proliferationviaNox-mediated generation of reactive oxygen species

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Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1

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In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

(2013) Hiroyuki Miyoshi et al.   Nature Protocols

TLR4 Activates the β-catenin Pathway to Cause Intestinal Neoplasia

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Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation

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Sustained Submicromolar H2O2Levels Induce Hepcidin via Signal Transducer and Activator of Transcription 3 (STAT3)

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Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair

(2012) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

(2012) Vivian W. Y. Wong et al.   NATURE CELL BIOLOGY

Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration

(2011) Dammanahalli K. Jagadeesha et al.   CARDIOVASCULAR RESEARCH

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

(2011) Erik Larsson et al.   GUT

Pattern Recognition Receptors and Inflammation

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Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Nox2 redox signaling maintains essential cell populations in the brain

(2010) Bryan C Dickinson et al.   Nature Chemical Biology

Potential role of Noxes in the protection of mucosae: H2O2 as abacterial repellent

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Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

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NOX enzymes and Toll-like receptor signaling

(2008) Eric Ogier-Denis et al.   Seminars in Immunopathology