Article
Gastroenterology & Hepatology
Joceline V. V. Vu, Jacob A. A. Kurowski, Jean-Paul Achkar, Tracy L. L. Hull, Jeremy Lipman, Stefan D. D. Holubar, Scott R. R. Steele, Amy L. L. Lightner
Summary: This study aimed to determine the healing rate of pediatric perianal Crohn's fistulas and identify factors associated with healing. The results showed that over two-thirds of fistulas heal in pediatric patients with conventional interventions. Younger age at fistula development is associated with an increased likelihood of healing.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Gastroenterology & Hepatology
Mathias Vidon, Nicolas Munoz-Bongrand, Jerome Lambert, Leon Maggiori, Jean-David Zeitoun, Helene Corte, Yves Panis, Philippe Seksik, Xavier Treton, Laurent Abramowitz, Matthieu Allez, Jean-Marc Gornet
Summary: The study suggests that using fibrin glue as an adjunct to conventional medical therapy may be an effective and safe treatment for perianal fistulas in patients with Crohn's disease. Patients who received combination therapy had a higher rate of complete clinical remission at 1 year.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Eun Mi Song, Ho-Su Lee, Ye-Jee Kim, Eun Hye Oh, Nam Seok Ham, Jeongseok Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
Summary: In Korean patients, the presence of pCD at CD diagnosis is associated with a lower risk of intestinal resection but does not significantly impact the risk of behavioral progression. pCD at diagnosis is an independent predictor of proctectomy and anorectal cancer.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Laura Maas, Ruiyi Gao, Vivy Cusumano, Ellen Spartz, Reezwana Chowdhury, Mahesh Krishna, Mark Lazarev, Joanna Melia, Florin Selaru, Sowmya Sharma, Berkeley Limketkai, Alyssa Parian
Summary: This study compared the efficacy of infliximab (IFX) and adalimumab (ADA) in healing CD-PAF. The results showed that the IFX group had better clinical response at 6 months and higher biologic persistence. In addition, the study supported the use of concomitant immunomodulator therapy for CD-PAF healing and remission.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
David A. Schwartz, Laurent Peyrin-Biroulet, Karen Lasch, Shashi Adsul, Silvio Danese
Summary: This study demonstrated that vedolizumab could significantly improve symptoms and quality of life in patients with fistulizing Crohn's disease, with positive effects on scar tissue formation in particular. Additionally, the addition of an extra dose at week 10 did not affect treatment outcomes. No new safety concerns were identified.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Alaa El-Hussuna, Camilla Engel Lemser, Aske Thorn Iversen, Kristine Hojgaard Allin, Tine Jess
Summary: This study aimed to examine the long-term risk of anorectal cancer in patients with Crohn's disease and anorectal fistula. The study found that CD fistula patients have a 2.9-fold increased risk of anorectal cancer compared to non-IBD individuals.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Jessica Breton, Ceylan Tanes, Vincent Tu, Lindsey Albenberg, Sarah Rowley, Nina Devas, Rosa Hwang, Kelly Kachelries, Gary D. Wu, Robert N. Baldassano, Kyle Bittinger, Peter Mattei
Summary: The microbial community in children with perianal fistulising CD is different in composition and function compared to other CD patients and healthy children, highlighting the importance of understanding the microbiome in the perianal milieu for developing treatment strategies.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Multidisciplinary Sciences
Zubing Mei, Qin Feng, Peixin Du, Bin Li, Chenyang Fang, Jinghua Gu, Yue Li, Haikun Zhou, Zhuo Shao, Maojun Ge, Yazhou He, Xuejun Yang, Qingming Wang
Summary: This study aims to evaluate the credibility of the published systematic reviews and meta-analyses that assess the efficacy and safety of surgical options for cryptoglandular and Crohn's perianal fistulas through an umbrella review. The results will provide more reliable evidence support for clinical practice.
Article
Gastroenterology & Hepatology
Mingming Zhu, Xitao Xu, Qi Feng, Zhe Cui, Tianrong Wang, Yunqi Yan, Zhihua Ran
Summary: The study demonstrated that infliximab induced deep radiological remission of perianal fistulas in Chinese patients with CD. Combined therapy using infliximab with azathioprine increased the fistula healing rate, while younger age at CD diagnosis, proctitis, and requiring perianal surgery were identified as predictors of poor deep radiological remission of fistulas.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Benedicte Caron, Ferdinando D'Amico, Silvio Danese, Laurent Peyrin-Biroulet
Summary: This systematic review described the evolution of endpoints in randomized controlled trials of perianal Crohn's disease patients and observed significant changes in outcomes used in these trials, indicating the increasing use of radiological endpoints in studies of perianal fistulizing Crohn's disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Medicine, General & Internal
Andreia Albuquerque, John Casey, Grace Fairlamb, Lesley A. Houghton, Christian Selinger
Summary: The study found that more than half of patients with treated/healed perianal Crohn's disease had sphincter abnormalities, many of whom were asymptomatic. Alterations in rectal sensation were frequently observed, with rectal hyposensitivity being more common.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Antoine Cazelles, Maxime K. Collard, Yoann Lalatonne, Sabrina Doblas, Magaly Zappa, Camelia Labiad, Dominique Cazals-Hatem, Leon Maggiori, Xavier Treton, Yves Panis, Ulrich Jarry, Thomas Desvallees, Pierre-Antoine Eliat, Raphael Pineau, Laurence Motte, Didier Letourneur, Teresa Simon-Yarza, Eric Ogier-Denis
Summary: Ultrasmall particles of iron oxide (USPIO) have shown promising results in the treatment of perianal fistulizing Crohn's disease, promoting healing and closure of fistula tracts in rat models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Shuang-Shuang Lu, Wen-Jia Liu, Qiu-Ya Niu, Chun-Yan Huo, Yu-Qing Cheng, En-Jing Wang, Rong-Nan Li, Fang-Fang Feng, Yi-Ming Cheng, Rong Liu, Jin Huang
Summary: In this study, an improved method of inducing colitis in rabbits successfully established a reliable and reproducible animal model of perianal fistulizing Crohn's disease, which was confirmed by endoscopy and histology.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Jiayin Yao, Heng Zhang, Tao Su, Xiang Peng, Junzhang Zhao, Tao Liu, Wei Wang, Pinjin Hu, Min Zhi, Min Zhang
Summary: There is insufficient evidence to confirm the efficacy of ustekinumab (UST) in promoting fistula closure in perianal fistulizing Crohn's disease (CD) patients. However, a real-world study found that UST can promote fistula closure and the efficacy is correlated with increased UST trough concentration.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jennifer Merten, Ann-Kathrin Eichelmann, Rudolf Mennigen, Isabelle Flammang, Andreas Pascher, Emile Rijcken
Summary: This study demonstrates that repetitive minor surgical interventions can increase the success rate of permanent closure of perianal fistulas in patients with Crohn's disease. The recurrence and healing of fistulas are closely related to the follow-up time and number of surgeries performed.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Ryuichi Kuwahara, Motoi Uchino, Hiroki Ikeuchi, Toshihiro Bando, Hirofumi Sasaki, Michiko Yasuhara, Kei Kimura, Yoshiko Goto, Yuki Horio, Tomohiro Minagawa, Masataka Ikeda, Takashi Ueda, Yoshio Takesue
Summary: This study aimed to investigate the efficacy of changing surgical instruments to prevent incisional surgical site infection during lower GI surgery. The results showed that changing surgical instruments did not decrease the rate of incisional surgical site infection in patients undergoing lower GI surgery in either all wound classes or clean-contaminated conditions.
DISEASES OF THE COLON & RECTUM
(2022)
Review
Pharmacology & Pharmacy
Kazuaki Matsumoto, Kazutaka Oda, Kensuke Shoji, Yuki Hanai, Yoshiko Takahashi, Satoshi Fujii, Yukihiro Hamada, Toshimi Kimura, Toshihiko Mayumi, Takashi Ueda, Kazuhiko Nakajima, Yoshio Takesue
Summary: This study provides guidelines for individualized dosing of vancomycin based on therapeutic drug monitoring. It suggests that AUC-guided dosing is more effective in reducing the risk of acute kidney injury compared to trough-guided dosing.
Review
Pharmacology & Pharmacy
Masaru Samura, Yuki Kitahiro, Sho Tashiro, Hiromu Moriyama, Yuna Hamamura, Isamu Takahata, Rina Kawabe, Yuki Enoki, Kazuaki Taguchi, Yoshio Takesue, Kazuaki Matsumoto
Summary: This systematic review and meta-analysis compares the efficacy of daptomycin and vancomycin in adult patients with bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) with a vancomycin minimum inhibitory concentration (MIC) > 1 mu g/mL. The results show that daptomycin treatment is associated with lower mortality and higher treatment success compared to vancomycin, regardless of the vancomycin MIC test method used. Daptomycin should be considered as a treatment option for MRSA bacteremia with a vancomycin MIC > 1 mu g/mL, especially in patients with intermediate- and high-risk bacteremia sources.
Article
Infectious Diseases
Takashi Ueda, Kazuhiko Nakajima, Kaoru Ichiki, Kaori Ishikawa, Kumiko Yamada, Toshie Tsuchida, Naruhito Otani, Yoshiko Takahashi, Mika Ishihara, Shingo Takubo, Kosuke Iijima, Hiroki Ikeuchi, Motoi Uchino, Takeshi Kimura, Yoshio Takesue
Summary: This study evaluated the efficacy of switching treatment to tedizolid in patients with vertebral osteomyelitis who developed thrombocytopenia during linezolid therapy. The results showed that switching to tedizolid improved thrombocytopenia and enabled the completion of therapy.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Virology
Naruhito Otani, Kazuhiko Nakajima, Kaori Ishikawa, Kaoru Ichiki, Yoshiko Yoda, Takashi Ueda, Yoshio Takesue, Takuma Yamamoto, Susumu Tanimura, Masayuki Shima, Toshiomi Okuno
Summary: In this study, antibody titers to influenza vaccine strains were measured in healthy volunteers over multiple seasons. The results showed significant differences in antibody titers for certain strains between seasons, indicating variation in cross-immunity. The consistency of antibody positivity varied between seasons, particularly for the B/Victoria strain. Assessment of antibody titers and consistency can provide valuable information on vaccine effectiveness.
Article
Ophthalmology
Takaaki Sugisawa, Hiroto Ishikawa, Kazutaka Uchida, Yoshio Takesue, Junya Mori, Takamasa Kinoshita, Shohei Morikawa, Fumiki Okamoto, Tomoko Sawada, Masahito Ohji, Takayuki Kanda, Masaru Takeuchi, Akiko Miki, Sentaro Kusuhara, Tetsuo Ueda, Nahoko Ogata, Masahiko Sugimoto, Mineo Kondo, Shigeo Yoshida, Tadahiko Ogata, Kazuhiro Kimura, Yoshinori Mitamura, Tatsuya Jujo, Hitoshi Takagi, Hiroto Terasaki, Taiji Sakamoto, Yuki Komuku, Fumi Gomi
Summary: This retrospective observational study investigated potential predictive factors for visual prognosis in Japanese patients with endogenous endophthalmitis. The study found that pressure injuries, severe clinical symptoms, pathogen identification, and poor baseline visual acuity were risk factors for visual impairment at 12 weeks after treatment initiation. Staphylococcus aureus and fungus were associated with a better visual impairment outcome.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Surgery
Tatsuki Hasegawa, Sho Tashiro, Takayuki Mihara, Junya Kon, Kazuki Sakurai, Yoko Tanaka, Takumi Morita, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto, Kazuhiko Nakajima, Yoshio Takesue
Summary: This study demonstrates the effectiveness of alcohol-based CHG solution with a 0.5 per cent or higher concentration in surgical skin preparation to prevent SSI, providing valuable insights for healthcare practices.
Review
Pharmacology & Pharmacy
Masaru Samura, Keisuke Takada, Naoki Hirose, Takenori Kurata, Fumio Nagumo, Masaki Uchida, Junki Inoue, Koji Tanikawa, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto, Takashi Ueda, Shigeru Fujimura, Hiroshige Mikamo, Yoshio Takesue, Kotaro Mitsutake
Summary: This study compared the efficacy of standard and high doses of daptomycin for different types of infections. The results showed that the treatment success rate was significantly lower in the standard-dose group compared to the high-dose group in patients with complicated bacteraemia/infective endocarditis. However, using the standard dose did not decrease the success rate for the treatment of osteomyelitis and foreign body/prosthetic infection. Therefore, higher doses of daptomycin are recommended for patients with complicated bacteraemia/infective endocarditis.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yoshio Takesue, Yuki Hanai, Kazutaka Oda, Yukihiro Hamada, Takashi Ueda, Toshihiko Mayumi, Kazuaki Matsumoto, Satoshi Fujii, Yoshiko Takahashi, Yoshitsugu Miyazaki, Toshimi Kimura
Summary: Increased adverse effects of Voriconazole, an antifungal drug, are observed in Asians due to the high rate of poor metabolizers. This therapeutic drug monitoring (TDM) guideline provides recommendations according to ethnic group.
CLINICAL THERAPEUTICS
(2022)
Article
Ophthalmology
Ayano Yoshimura, Hiroto Ishikawa, Kazutaka Uchida, Yoshio Takesue, Junya Mori, Takamasa Kinoshita, Shohei Morikawa, Fumiki Okamoto, Tomoko Sawada, Masahito Ohji, Takayuki Kanda, Masaru Takeuchi, Akiko Miki, Sentaro Kusuhara, Tetsuo Ueda, Nahoko Ogata, Masahiko Sugimoto, Mineo Kondo, Shigeo Yoshida, Tadahiko Ogata, Kazuhiro Kimura, Yoshinori Mitamura, Tatsuya Jujo, Hitoshi Takagi, Hiroto Terasaki, Taiji Sakamoto, Takaaki Sugisawa, Yuki Komuku-Yamamoto, Fumi Gomi
Summary: This study investigated the potential risk factors for visual prognosis in Japanese patients with exogenous endophthalmitis. Risk factors for legal blindness at 12 weeks after treatment initiation were evaluated based on patient characteristics, initial BCVA, causative events, pathogens, ocular symptoms, duration from symptom onset to initial treatment, and selected treatments. The results showed that 23.1% of eyes developed legal blindness. The six risk factors for legal blindness were presence of eye pain, pathogen identification, poor BCVA at the initial visit, longer duration from symptom onset to initial treatment, type of causative event, and type of causative pathogen.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Hideki Ogura, Jin Gohda, Xiuyuan Lu, Mizuki Yamamoto, Yoshio Takesue, Aoi Son, Sadayuki Doi, Kazuyuki Matsushita, Fumitaka Isobe, Yoshihiro Fukuda, Tai-Ping Huang, Takamasa Ueno, Naomi Mambo, Hiromoto Murakami, Yasushi Kawaguchi, Jun-ichiro Inoue, Kunihiro Shirai, Sho Yamasaki, Jun-Ichi Hirata, Satoshi Ishido
Summary: This study explores the characteristics of virus-specific CTLs related to the severity of COVID-19. Through the establishment of a cellular screening method, the researchers found that the SARS-CoV-2 M protein is a frequent target of CD8(+) T cells, and identified M198-206 as an immunoprevalent epitope in convalescent COVID-19 patients. Further single cell RNA sequencing revealed an exhausted phenotype with less differentiated status in cells from the severe group compared to cells from the moderate group.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Takashi Ueda, Yoshio Takesue, Kazuhiko Nakajima, Kaoru Ichiki, Kaori Ishikawa, Kumiko Yamada, Toshie Tsuchida, Naruhito Otani, Yoshiko Takahashi, Mika Ishihara, Shingo Takubo, Kosuke Iijima, Hiroki Ikeuchi, Motoi Uchino, Takeshi Kimura
Summary: This study investigated the correlation between antibiotic diversity and antimicrobial resistance (AMR) in Gram-negative organisms. The findings suggest that antibiotic heterogeneity is negatively associated with the development of antibiotic resistance in Pseudomonas aeruginosa and Klebsiella pneumoniae.
Article
Multidisciplinary Sciences
Mika Morosawa, Takashi Ueda, Kazuhiko Nakajima, Tomoko Inoue, Masanobu Toyama, Hitoshi Ogasiwa, Miki Doi, Yasuhiro Nozaki, Yasushi Murakami, Makoto Ishii, Yoshio Takesue
Summary: This study aimed to compare the amount and diversity of antibiotic use and antimicrobial susceptibility of nosocomial isolates between a community hospital (CH) and a tertiary care hospital (TCH) in Japan. The study found that the TCH had a higher antibiotic use rate than the CH, but there was no significant difference in antimicrobial susceptibility. This suggests that increased antibiotic use in the TCH does not lead to increased resistance, possibly due to diversified antibiotic use. Therefore, assessing antibiotic use according to facility type is an effective method for evaluating antimicrobial stewardship programs.
Article
Infectious Diseases
Yasushi Murakami, Hitoshi Ogashiwa, Yasuhiro Nozaki, Takashi Ueda, Kazuhiko Nakajima, Mika Morosawa, Miki Doi, Miyuki Makino, Yoshio Takesue
Summary: Extending isolation for hospitalized COVID-19 patients is necessary. Utilizing Ct values to determine the end of isolation can shorten hospital stay, reduce testing frequency, and minimize the risk of nosocomial transmission.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Review
Immunology
Naruhito Otani, Masayuki Shima, Takashi Ueda, Kazuhiko Nakajima, Yoshio Takesue, Takuma Yamamoto, Toshiomi Okuno
Summary: Rubella is caused by a virus and poses a risk to newborns if pregnant women are infected. Japan has implemented routine immunization, but recent outbreaks indicate a potential failure in the introduction of rubella vaccination. In Japan, only junior high school girls initially received routine rubella immunization, leading to a high rate of susceptibility among unvaccinated males.