Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease

Selective toxicity of Catechin—a natural flavonoid towards bacteria

(2016) Aafreen Fathima et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia

(2016) Yi-Shiou Chiou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bioactivity of Polyphenols: Preventive and Adjuvant Strategies toward Reducing Inflammatory Bowel Diseases—Promises, Perspectives, and Pitfalls

(2016) Anouk Kaulmann et al.   Oxidative Medicine and Cellular Longevity

The chemistry of gut microbial metabolism of polyphenols

(2016) Jan F. Stevens et al.   PHYTOCHEMISTRY REVIEWS

Interactions between Obesity Status and Dietary Intake of Monounsaturated and Polyunsaturated Oils on Human Gut Microbiome Profiles in the Canola Oil Multicenter Intervention Trial (COMIT)

(2016) Shuaihua Pu et al.   Frontiers in Microbiology

Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis

(2016) Maitham A. Khajah et al.   PLoS One

(−)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity

(2015) Telma C. Contreras et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Levels of Drug and Antidrug Antibodies Are Associated With Outcome of Interventions After Loss of Response to Infliximab or Adalimumab

(2015) Henit Yanai et al.   Clinical Gastroenterology and Hepatology

The Role of Dietary Polyphenols in the Management of Inflammatory Bowel Disease

(2015) Mohammad Farzaei et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Condensed catechins and their potential health-benefits

(2015) Toshiro Matsui   EUROPEAN JOURNAL OF PHARMACOLOGY

Catechin-7-O- β -D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats

(2015) Sung-Ho Kook et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice: Possible mechanisms

(2015) Ashok Kumar Pandurangan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oridonin's therapeutic effect: Suppressing Th1/Th17 simultaneously in a mouse model of Crohn's disease

(2015) Shubei Wang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focusing on carotenoids and polyphenols

(2015) Torsten Bohn et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4/NFκB p65 signal pathway

(2015) M.P. Marinovic et al.   TOXICOLOGY IN VITRO

Lotus Leaf (Nelumbo nucifera) and its Active Constituents Prevent Inflammatory Responses in Macrophages via JNK/NF-κB Signaling Pathway

(2014) Shing-Hwa Liu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Gordonibacter faecihominis sp. nov., isolated from human faeces

(2014) Jong-Sik Jin et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

A β-glucosidase from Novosphingobium sp. GX9 with high catalytic efficiency toward isoflavonoid glycoside hydrolysis and (+)-catechin transglycosylation

(2014) Liqin Du et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

(2014) Subash C. Gupta et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metabolism of Flavonoids in Human: A Comprehensive Review

(2014) Zhongjian Chen et al.   CURRENT DRUG METABOLISM

Epigallocatechin-3-gallate sensitizes IFN-γ-stimulated CD4+ T cells to apoptosis via alternative activation of STAT1

(2014) Xingxin Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Faecal Metabolomic Fingerprint after Moderate Consumption of Red Wine by Healthy Subjects

(2014) Ana Jiménez-Girón et al.   JOURNAL OF PROTEOME RESEARCH

Tailoring anti-TNF therapy in IBD: drug levels and disease activity

(2014) Shomron Ben-Horin et al.   Nature Reviews Gastroenterology & Hepatology

Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?

(2014) Georgina L Hold   WORLD JOURNAL OF GASTROENTEROLOGY

Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols

(2013) Michael N Clifford et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Oligonol Inhibits Dextran Sulfate Sodium-Induced Colitis and Colonic Adenoma Formation in Mice

(2013) Hye-Won Yum et al.   ANTIOXIDANTS & REDOX SIGNALING

EGCG inhibit chemical reactivity of iron through forming an Ngal–EGCG–iron complex

(2013) Guan-Hu Bao et al.   BIOMETALS

Effect of natural polyphenols (Pycnogenol) on oxidative stress markers in children suffering from Crohn's disease – a pilot study

(2013) M. Koláček et al.   FREE RADICAL RESEARCH

A Pilot Study to Evaluate the Safety and Efficacy of an Oral Dose of (−)-Epigallocatechin-3-Gallate–Rich Polyphenon E in Patients With Mild to Moderate Ulcerative Colitis

(2013) Gerald W. Dryden et al.   INFLAMMATORY BOWEL DISEASES

Polyphenols Protect the Epithelial Barrier Function of Caco-2 Cells Exposed to Indomethacin through the Modulation of Occludin and Zonula Occludens-1 Expression

(2013) Catalina Carrasco-Pozo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Abarema cochliacarpos reduces LPS-induced inflammatory response in murine peritoneal macrophages regulating ROS-MAPK signal pathway

(2013) S. Sánchez-Fidalgo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Glutathione and the Antioxidant Potential of Binary Mixtures with Flavonoids: Synergisms and Antagonisms

(2013) Renato Pereira et al.   MOLECULES

Comparative Evaluation of Different Co-Antioxidants on the Photochemical- and Functional-Stability of Epigallocatechin-3-gallate in Topical Creams Exposed to Simulated Sunlight

(2013) Santo Scalia et al.   MOLECULES

Concepts of oxidative stress and antioxidant defense in Crohn’s disease

(2013) Mohammed A Alzoghaibi   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of anthocyanin-rich tea “Sunrouge” on dextran sodium sulfate-induced colitis in mice

(2012) Satoko Akiyama et al.   BIOFACTORS

Isolation and Characterization of a Human Intestinal Bacterium Eggerthella sp. CAT-1 Capable of Cleaving the C-Ring of (+)-Catechin and (^|^#8722;)-Epicatechin, Followed by p-Dehydroxylation of the B-Ring

(2012) Jong-Sik Jin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models

(2012) Paulo César de Paula Vasconcelos et al.   Evidence-based Complementary and Alternative Medicine

Peracetylated (−)-Epigallocatechin-3-gallate (AcEGCG) Potently Suppresses Dextran Sulfate Sodium-Induced Colitis and Colon Tumorigenesis in Mice

(2012) Yi-Shiou Chiou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The role of the gut microbiota in nutrition and health

(2012) Harry J. Flint et al.   Nature Reviews Gastroenterology & Hepatology

Deleterious Effects of High Concentrations of (-)-Epigallocatechin-3-Gallate and Atorvastatin in Mice With Colon Inflammation

(2012) Fei Guan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

(2011) M.A. Rosillo et al.   BIOCHEMICAL PHARMACOLOGY

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

(2011) Alan W Walker et al.   BMC MICROBIOLOGY

Polyphenol Supplementation as a Complementary Medicinal Approach to Treating Inflammatory Bowel Disease

(2011) F. Biasi et al.   CURRENT MEDICINAL CHEMISTRY

Dietary flavonoids: Role of (−)-epicatechin and related procyanidins in cell signaling

(2011) Cesar G. Fraga et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of Ulcerative Colitis in Mice after Oral Administration of a Polyphenol-Enriched Cocoa Extract Is Mediated by the Inhibition of STAT1 and STAT3 Phosphorylation in Colon Cells

(2011) Isabel Andújar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isolation of catechin-converting human intestinal bacteria

(2011) M. Kutschera et al.   JOURNAL OF APPLIED MICROBIOLOGY

Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis

(2011) Markus Brückner et al.   Journal of Crohns & Colitis

Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate

(2011) Min-Hsiung Pan et al.   Food & Function

Extraintestinal manifestations of inflammatory bowel disease: Epidemiology, diagnosis, and management

(2010) Signe Larsen et al.   ANNALS OF MEDICINE

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Down-regulation of connexin43 gap junction by serum deprivation in human endothelial cells was improved by (−)-Epigallocatechin gallate via ERK MAP kinase pathway

(2010) Yanbo Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Signaling Functions of Reactive Oxygen Species

(2010) Henry Jay Forman et al.   BIOCHEMISTRY

The modifying effects of green tea polyphenols on acute colitis and inflammation-associated colon carcinogenesis in male ICR mice

(2010) Mihye Kim et al.   BIOFACTORS

Epigallocatechin-3 Gallate, a Green Tea Catechin, Attenuated the Downregulation of the Cardiac Gap Junction Induced by High Glucose in Neonatal Rat Cardiomyocytes

(2010) Lu Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

High polyphenol, low probiotic diet for weight loss because of intestinal microbiota interaction

(2010) Reza Rastmanesh   CHEMICO-BIOLOGICAL INTERACTIONS

Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells

(2010) Ildefonso Rodríguez-Ramiro et al.   EUROPEAN JOURNAL OF NUTRITION

The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo

(2010) Javier I. Ottaviani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Importance of disrupted intestinal barrier in inflammatory bowel diseases

(2010) Saʼad Y. Salim et al.   INFLAMMATORY BOWEL DISEASES

Chocolate Matrix Factors Modulate the Pharmacokinetic Behavior of Cocoa Flavan-3-ol Phase II Metabolites Following Oral Consumption by Sprague−Dawley Rats

(2010) Andrew P. Neilson et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-inflammatory intestinal activity of Abarema cochliacarpos (Gomes) Barneby & Grimes in TNBS colitis model

(2010) Maria Silene da Silva et al.   JOURNAL OF ETHNOPHARMACOLOGY

Abarema cochliacarpos: Gastroprotective and ulcer-healing activities

(2010) Maria Silene da Silva et al.   JOURNAL OF ETHNOPHARMACOLOGY

Targeting of histamine producing cells by EGCG: a green dart against inflammation?

(2010) Esther Melgarejo et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Basic biochemical mechanisms behind the health benefits of polyphenols

(2010) Cesar G. Fraga et al.   MOLECULAR ASPECTS OF MEDICINE

Food-derived bioactives as potential regulators of the IL-12/IL-23 pathway implicated in inflammatory bowel diseases

(2010) Francesca Danesi et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Bioavailability and catabolism of green tea flavan-3-ols in humans

(2010) Daniele Del Rio et al.   NUTRITION

Development, regulation and functional capacities of Th17 cells

(2010) Keiji Hirota et al.   Seminars in Immunopathology

Dynamics and functions of tight junctions

(2010) Emily Steed et al.   TRENDS IN CELL BIOLOGY

Neuroprotective effect of epigallocatechin-3-gallate against β-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity

(2009) Chang-Yul Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

Characterization of Pu-erh Tea Using Chemical and Metabolic Profiling Approaches

(2009) Guoxiang Xie et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Comparative Safety Evaluation of Chinese Pu-erh Green Tea Extract and Pu-erh Black Tea Extract in Wistar Rats

(2009) Di Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cells☆

(2009) María Ángeles Martín et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Influence of apple polyphenols on inflammatory gene expression

(2009) Mathias Jung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy

(2009) Angélique Stalmach et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Epigallocatechin-3-gallate Inhibits Osteoclastogenesis by Down-Regulating c-Fos Expression and Suppressing the Nuclear Factor- B Signal

(2009) J.-H. Lee et al.   MOLECULAR PHARMACOLOGY

Flavonoids inhibit the genotoxicity of hydrogen peroxide (H2O2) and of the food mutagen 2-amino-3-methylimadazo[4,5-f]-quinoline (IQ) in lymphocytes from patients with inflammatory bowel disease (IBD)

(2009) M. Najafzadeh et al.   MUTAGENESIS

(-)-epigallocatechin-3-gallate reduces experimental colon injury in rats by regulating macrophage and mast cell

(2009) Miyako Mochizuki et al.   PHYTOTHERAPY RESEARCH

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

(-)-Epigallocatechin Gallate Suppresses Azoxymethane-Induced Colonic Premalignant Lesions in Male C57BL/KsJ-db/db Mice

(2008) M. Shimizu et al.   Cancer Prevention Research

Role of Catechin Quinones in the Induction of EpRE-Mediated Gene Expression

(2008) Małgorzata Muzolf-Panek et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effects of epigallocatechin-3-gallate on mitochondrial integrity and antioxidative enzyme activity in the aging process of human fibroblast

(2008) Qingying Meng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of Gap Junctional Intercellular Communication by the Green Tea Polyphenol (−)-Epigallocatechin Gallate in Normal Rat Liver Epithelial Cells

(2008) Nam Joo Kang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Microbial metabolism of catechin stereoisomers by human faecal microbiota: Comparison of targeted analysis and a non-targeted metabolomics method

(2008) Anna-Marja Aura et al.   Phytochemistry Letters

Role of STAT3 in inflammatory bowel disease

(2008) Ken Sugimoto   WORLD JOURNAL OF GASTROENTEROLOGY

Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis

(2007) Patricia A. Abboud et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohnʼs disease and analysis of the IL17F p.His161Arg polymorphism in IBD

(2007) Julia Seiderer et al.   INFLAMMATORY BOWEL DISEASES