Heparin, Heparan Sulphate and the TGF-β Cytokine Superfamily

Growth Differentiation Factor 5-Mediated Enhancement of Chondrocyte Phenotype Is Inhibited by Heparin: Implications for the Use of Heparin in the Clinic and in Tissue Engineering Applications

(2017) Bethanie I. Ayerst et al.   TISSUE ENGINEERING PART A

Revisiting the regulatory roles of the TGF-β family of cytokines

(2016) Keshi Fujio et al.   AUTOIMMUNITY REVIEWS

Structural insights into BMP receptors: Specificity, activation and inhibition

(2016) David Yadin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease

(2016) Pia Runeberg-Roos et al.   NEUROBIOLOGY OF DISEASE

Is Heparin Effective for the Controlled Delivery of High-Dose Bone Morphogenetic Protein-2?

(2016) Ri Youn Kim et al.   TISSUE ENGINEERING PART A

Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism

(2016) Kristof Nolan et al.   Cell Reports

Mapping the heparin-binding site of the BMP antagonist gremlin by site-directed mutagenesis based on predictive modelling

(2015) Arnold Junior Tatsinkam et al.   BIOCHEMICAL JOURNAL

BMP signalling: agony and antagony in the family

(2015) Derek P. Brazil et al.   TRENDS IN CELL BIOLOGY

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

(2015) Tao-Hsin Chang et al.   eLife

A mutation in the heparin-binding site of noggin as a novel mechanism of proximal symphalangism and conductive hearing loss

(2014) Sawako Masuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2

(2014) Marian H. Hettiaratchi et al.   BIOMATERIALS

Improving osteoblast functions and bone formation upon BMP-2 immobilization on titanium modified with heparin

(2014) Sung Eun Kim et al.   CARBOHYDRATE POLYMERS

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson′s disease

(2014) GerardW O′Keeffe et al.   Neural Regeneration Research

Dual effects of heparin on BMP-2-induced osteogenic activity in MC3T3-E1 cells

(2014) Shin Kanzaki et al.   Pharmacological Reports

Cooperative Heparin-Mediated Oligomerization of Fibroblast Growth Factor-1 (FGF1) Precedes Recruitment of FGFR2 to Ternary Complexes

(2013) Alan Brown et al.   BIOPHYSICAL JOURNAL

Exogenous heparin binds and inhibits bone morphogenetic protein 6 biological activity

(2013) Jelena Brkljacic et al.   INTERNATIONAL ORTHOPAEDICS

Structure of Protein Related to Dan and Cerberus: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism

(2013) Kristof Nolan et al.   STRUCTURE

Analysis of the Interaction between Heparin and Follistatin and Heparin and Follistatin–Ligand Complexes Using Surface Plasmon Resonance

(2012) Fuming Zhang et al.   BIOCHEMISTRY

Prediction of heparin binding sites in bone morphogenetic proteins (BMPs)

(2012) Neha S. Gandhi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

(2012) Hua Gao et al.   CELL

Heparan Sulfate Proteoglycans Regulate Responses to Oocyte Paracrine Signals in Ovarian Follicle Morphogenesis

(2012) Laura N. Watson et al.   ENDOCRINOLOGY

Heparan Sulfate Facilitates FGF and BMP Signaling to Drive Mesoderm Differentiation of Mouse Embryonic Stem Cells

(2012) Daniel C. Kraushaar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Follistatin-Type Domains and Their Contribution to Myostatin and Activin A Antagonism

(2012) Jennifer N. Cash et al.   MOLECULAR ENDOCRINOLOGY

Fractone-heparan sulfates mediate BMP-7 inhibition of cell proliferation in the adult subventricular zone

(2012) Vanessa Douet et al.   NEUROSCIENCE LETTERS

Heparan Sulfate Proteoglycans Mediate the Angiogenic Activity of the Vascular Endothelial Growth Factor Receptor-2 Agonist Gremlin

(2011) Paola Chiodelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2)

(2011) Diah S. Bramono et al.   BONE

Structure of Myostatin·Follistatin-like 3

(2011) Jennifer N. Cash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin

(2011) Maxim M. Bespalov et al.   JOURNAL OF CELL BIOLOGY

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

(2010) Christopher C. Rider et al.   BIOCHEMICAL JOURNAL

Influencing Hematopoietic Differentiation of Mouse Embryonic Stem Cells using Soluble Heparin and Heparan Sulfate Saccharides

(2010) Rebecca J. Holley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

(2009) Jennifer N Cash et al.   EMBO JOURNAL

Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons

(2009) Marjo Piltonen et al.   EXPERIMENTAL NEUROLOGY

Characterization of the Structural Features and Interactions of Sclerostin

(2009) Vaclav Veverka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous heparan sulfate and heparin modulate bone morphogenetic protein-4 signaling and activity

(2008) Shaukat A. Khan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Roles of TGF-β family signaling in stem cell renewal and differentiation

(2008) Tetsuro Watabe et al.   CELL RESEARCH

Evidence That Heparin Saccharides Promote FGF2 Mitogenesis through Two Distinct Mechanisms

(2008) Sarah J. Goodger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparin inhibits BMP‐2 osteogenic bioactivity by binding to both BMP‐2 and BMP receptor

(2008) Shin Kanzaki et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface

(2007) Takuya Akiyama et al.   DEVELOPMENTAL BIOLOGY