Origins, Phytochemistry, Pharmacology, Analytical Methods and Safety of Cortex Moutan (Paeonia suffruticosa Andrew): A Systematic Review

UPLC-QTOF-MS based metabolomics coupled with the diagnostic ion exploration strategy for rapidly evaluating sulfur-fumigation caused holistic quality variation in medicinal herbs, Moutan Cortex as an example

(2016) Xiu-Yang Li et al.   Analytical Methods

Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway

(2016) Qiang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Moutan cortex extract exerts protective effects in a rat model of cardiac ischemia/reperfusion

(2016) Hong Dan et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The protective effects of paeonol against epirubicin-induced hepatotoxicity in 4T1-tumor bearing mice via inhibition of the PI3K/Akt/NF-kB pathway

(2016) Jing Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Application of a quantitative 1H-NMR method for the determination of paeonol in Moutan cortex, Hachimijiogan and Keishibukuryogan

(2016) Rie Tanaka et al.   Journal of Natural Medicines

Unique immunomodulatory effect of paeoniflorin on type I and II macrophages activities

(2016) Tianhang Zhai et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Paeonol enhances thrombus recanalization by inducing vascular endothelial growth factor 165 via ERK1/2 MAPK signaling pathway

(2016) SONGSHAN YE et al.   Molecular Medicine Reports

Thrombosis recanalization by paeoniflorin through the upregulation of urokinase-type plasminogen activator via the MAPK signaling pathway

(2016) SONGSHAN YE et al.   Molecular Medicine Reports

A new phenone from the roots of Paeonia suffruticosa Andrews

(2016) Liqin Ding et al.   NATURAL PRODUCT RESEARCH

Liquid chromatography-diode array detector-electrospray mass spectrometry and principal components analyses of raw and processed moutan cortex

(2016) Bin Zhao et al.   Pharmacognosy Magazine

Paeonol Protects Rat Heart by Improving Regional Blood Perfusion during No-Reflow

(2016) Lina Ma et al.   Frontiers in Physiology

Paeoniflorin protects against concanavalin A-induced hepatitis in mice

(2015) Mingsheng Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects of Paeonol on Anti-Neuroinflammatory Responses in Microglial Cells

(2015) Chingju Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Paeonol inhibits B16F10 melanoma metastasisIn vitroandIn Vivovia disrupting proinflammatory cytokines-mediated NF-κB and STAT3 pathways

(2015) Lei Zhang et al.   IUBMB LIFE

Paeoniflorin inhibits proliferation and induces apoptosis of human glioma cells via microRNA-16 upregulation and matrix metalloproteinase-9 downregulation

(2015) WEIHUA LI et al.   Molecular Medicine Reports

Paeoniflorin ameliorates acute myocardial infarction of rats by inhibiting inflammation and inducible nitric oxide synthase signaling pathways

(2015) CHANG CHEN et al.   Molecular Medicine Reports

Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway

(2015) H. Dong et al.   NEUROSCIENCE

Screening nephroprotective compounds from cortex Moutan by mesangial cell extraction and UPLC

(2014) Min Sun et al.   ARCHIVES OF PHARMACAL RESEARCH

Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma

(2014) Yetao Ou et al.   Biomolecules & Therapeutics

Combining HPLC–DAD and ICP-MS data for improved analysis of complex samples: Classification of the root samples from Cortex moutan

(2014) Hua Zhuang et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Isolation of antifungal compound from Paeonia suffruticosa and its antifungal mechanism

(2014) Yong Zhao et al.   Chinese Journal of Integrative Medicine

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

(2014) Yanling Zhao et al.   FITOTERAPIA

Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson’s disease

(2014) Hyo Geun Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway

(2014) Chi-Ting Horng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrating traditional Chinese medicine healthcare into diabetes care by reducing the risk of developing kidney failure among type 2 diabetic patients: A population-based case control study

(2014) Pei-Chien Hsu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Paeonol Attenuates Cigarette Smoke-Induced Lung Inflammation by Inhibiting ROS-Sensitive Inflammatory Signaling

(2014) Meng-Han Liu et al.   MEDIATORS OF INFLAMMATION

A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-Wei-Di-Huang pill as a case study

(2014) Xujun Liang et al.   Molecular BioSystems

A Novel Method HPLC-DAD Analysis of the Contentsof Moutan Cortexand Paeoniae Radix Alba with Similar Constituents-Monoterpene Glycosides in Guizhi Fuling Wan

(2014) Shuyun Wang et al.   MOLECULES

Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE2 synthesis and COX-2 expression

(2014) MING LI et al.   ONCOLOGY REPORTS

The Attenuation of Moutan Cortex on Oxidative Stress for Renal Injury in AGEs-Induced Mesangial Cell Dysfunction and Streptozotocin-Induced Diabetic Nephropathy Rats

(2014) Minghua Zhang et al.   Oxidative Medicine and Cellular Longevity

Quick comparison of Radix Paeonia Alba, Radix Paeonia Rubra, and Cortex Moutan by high performance liquid chromatography coupled with monolithic columns and their chemical pattern recognition

(2014) Xiao Peigen et al.   Pharmacognosy Magazine

Revealing Metabolomic Variations in Cortex Moutan from Different Root Parts using HPLC-MS method

(2014) Chaoni Xiao et al.   PHYTOCHEMICAL ANALYSIS

Chemical taxonomy of tree peony species from China based on root cortex metabolic fingerprinting

(2014) Chunnian He et al.   PHYTOCHEMISTRY

Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2

(2014) Jiangxia Cai et al.   PHYTOMEDICINE

Multiple species of wild tree peonies gave rise to the 'king of flowers', Paeonia suffruticosa Andrews

(2014) S.-L. Zhou et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Serum pharmacochemistry combined with multiple data processing approach to screen the bioactive components and their metabolites in Mutan Cortex by ultra-performance liquid chromatography tandem mass spectrometry

(2013) Jian-hua Liu et al.   BIOMEDICAL CHROMATOGRAPHY

6'-O-Galloylpaeoniflorin Protects Human Keratinocytes Against Oxidative Stress-Induced Cell Damage

(2013) Cheng Wen Yao et al.   Biomolecules & Therapeutics

Paeoniflorin, a monoterpene glycoside, attenuates lipopolysaccharide-induced neuronal injury and brain microglial inflammatory response

(2013) Kyong-Nyon Nam et al.   BIOTECHNOLOGY LETTERS

Paeoniflorin suppresses vascular damage and the expression of E-selectin and ICAM-1 in a mouse model of cutaneous Arthus reaction

(2013) Tao Chen et al.   EXPERIMENTAL DERMATOLOGY

Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock

(2013) Na Chen et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

The anti-inflammation effect of Moutan Cortex on advanced glycation end products-induced rat mesangial cells dysfunction and High-glucose–fat diet and streptozotocin-induced diabetic nephropathy rats

(2013) Ming-hua Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

ZnSe quantum dots based fluorescence quenching method for determination of paeoniflorin

(2013) Zhi Chen et al.   JOURNAL OF LUMINESCENCE

Hypoglycemic and Antioxidant Activities of Paeonol and Its Beneficial Effect on Diabetic Encephalopathy in Streptozotocin-Induced Diabetic Rats

(2013) Jiping Liu et al.   JOURNAL OF MEDICINAL FOOD

Neuroprotective Effects of Paeoniflorin, But Not the Isomer Albiflorin, are Associated with the Suppression of Intracellular Calcium and Calcium/Calmodulin Protein Kinase II in PC12 Cells

(2013) Di Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Anticomplement Monoterpenoid Glucosides from the Root Bark of Paeonia suffruticosa

(2013) Wei-Hua Song et al.   JOURNAL OF NATURAL PRODUCTS

Anti-Inflammatory and Anti-Allergic Activities of Pentaherb Formula, Moutan Cortex (Danpi) and Gallic Acid

(2013) Kelly Liu et al.   MOLECULES

New monoterpene glycosides from the root cortex ofPaeonia suffruticosaand their potential anti-inflammatory activity

(2013) Xia Zhu et al.   NATURAL PRODUCT RESEARCH

Paeoniflorin protects human EA.hy926 endothelial cells against gamma-radiation induced oxidative injury by activating the NF-E2-related factor 2/heme oxygenase-1 pathway

(2013) Jing Yu et al.   TOXICOLOGY LETTERS

Copper and bacterial diversity in soil enhance paeonol accumulation in cortex moutan of Paeonia suffruticosa ‘Fengdan’

(2013) Yanli Liu et al.   Horticulture Environment and Biotechnology

Bioassay-guided isolation of novel compound from Paeonia suffruticosa Andrews roots as an IL-1β inhibitor

(2012) Yun-Hyeok Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Paeonol Inhibits Oxidized Low Density Lipoprotein-Induced Monocyte Adhesion to Vascular Endothelial Cells by Inhibiting the Mitogen Activated Protein Kinase Pathway

(2012) Yue-Qin Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells

(2012) Liqin Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Monoterpenoid inhibitors of NO production from Paeonia suffruticosa

(2012) Liqin Ding et al.   FITOTERAPIA

Wound-healing plants from TCM: in vitro investigations on selected TCM plants and their influence on human dermal fibroblasts and keratinocytes

(2012) Ruxi Wang et al.   FITOTERAPIA

Original article Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2/Bax signal pathway

(2012) Rong Sun et al.   FOLIA NEUROPATHOLOGICA

Determination of trace elements in commonly consumed medicinal herbs by ICP-MS and multivariate analysis

(2012) Şerife Tokalıoğlu   FOOD CHEMISTRY

Inhibitory effects of paeoniflorin on lysophosphatidylcholine-induced inflammatory factor production in human umbilical vein endothelial cells

(2012) JIAN-ZHE LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Moutan Cortex Radicis inhibits inflammatory changes of gene expression in lipopolysaccharide-stimulated gingival fibroblasts

(2012) Cheol-Sang Yun et al.   Journal of Natural Medicines

Suffruyabiosides A and B, Two New Monoterpene Diglycosides from Moutan Cortex

(2012) Rie Furuya et al.   MOLECULES

Moutan cortex radicis improves lipopolysaccharide-induced acute lung injury in rats through anti-inflammation

(2012) Pin-Kuei Fu et al.   PHYTOMEDICINE

Cardioprotective Effect of Paeonol and Danshensu Combination on Isoproterenol-Induced Myocardial Injury in Rats

(2012) Hua Li et al.   PLoS One

Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKs/NF-κB-Mediated Inflammatory Responses

(2012) Ruo-Bing Guo et al.   PLoS One

Paeonol from Hippocampus kuda Bleeler suppressed the neuro-inflammatory responses in vitro via NF-κB and MAPK signaling pathways

(2012) S.W.A. Himaya et al.   TOXICOLOGY IN VITRO

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease

(2011) Jun Zhou et al.   BRAIN RESEARCH

ASICs mediate the modulatory effect by paeoniflorin on alpha-synuclein autophagic degradation

(2011) Xue Sun et al.   BRAIN RESEARCH

Paeonol Attenuates Microglia-Mediated Inflammation and Oxidative Stress–Induced Neurotoxicity in Rat Primary Microglia and Cortical Neurons

(2011) Yu-Ting Tseng et al.   SHOCK

Chinese herbal medicine research in eczema treatment

(2011) Kam Hon et al.   Chinese Medicine

Paeonol Attenuates H2O2-Induced NF-κB-Associated Amyloid Precursor Protein Expression

(2010) Shan-Yu Su et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Inhibitory Effects ofPaeonia suffruticosaon Allergic Reactions by Inhibiting the NF-kappaB/IkappaB-alpha Signaling Pathway and Phosphorylation of ERK in an Animal Model and Human Mast Cells

(2010) Myung Hee HONG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Quality Evaluation of Moutan Cortex Radicis Using Multiple Component Analysisby High Performance Liquid Chromatography

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Phytochemical and Biological Studies of Paeoniaceae

(2010) Chun-Nian He et al.   CHEMISTRY & BIODIVERSITY

Chemical Constituents and Bioactivities of Plants from the GenusPaeonia

(2010) Shao-Hua Wu et al.   CHEMISTRY & BIODIVERSITY

Three New Paeonidanin-Type Monoterpene Glycosides from Paeonia suffruticosaAndr.

(2010) Yu Yang et al.   HELVETICA CHIMICA ACTA

Modified glassy carbon electrode with Nafion/MWNTs as a sensitive voltammetric sensor for the determination of paeonol in pharmaceutical and biological samples

(2010) Suling Yang et al.   JOURNAL OF APPLIED ELECTROCHEMISTRY

Selected compounds derived from Moutan Cortex stimulated glucose uptake and glycogen synthesis via AMPK activation in human HepG2 cells

(2010) Do Thi Ha et al.   JOURNAL OF ETHNOPHARMACOLOGY

Paeonol, the main active principles of Paeonia moutan, ameliorates alcoholic steatohepatitis in mice

(2010) Shilian Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

CdSe/ZnS quantum dots based fluorescence quenching method for determination of paeonol

(2010) Wei Dong et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Vascular dilation by paeonol — A mechanism study

(2010) Ya-juan Li et al.   VASCULAR PHARMACOLOGY

Paeonol inhibits tumor growth in gastric cancerin vitroandin vivo

(2010) Na Li   WORLD JOURNAL OF GASTROENTEROLOGY

Recent analytical approaches in quality control of traditional Chinese medicines—A review

(2009) Yong Jiang et al.   ANALYTICA CHIMICA ACTA

Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells

(2009) Do Thi Ha et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lead and Cadmium Accumulation in Medicinal Plants Collected from Environmentally Different Sites

(2009) Henok Baye et al.   BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Inhibitors of Aldose Reductase and Formation of Advanced Glycation End-Products in Moutan Cortex (Paeonia suffruticosa)

(2009) Do Thi Ha et al.   JOURNAL OF NATURAL PRODUCTS

A traditional medicinal herbPaeonia suffruticosaand its active constituent 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose have potent anti-aggregation effects on Alzheimer’s amyloid β proteinsin vitroandin vivo

(2009) Hironori Fujiwara et al.   JOURNAL OF NEUROCHEMISTRY

DNA barcoding: species delimitation in tree peonies

(2009) JinMei Zhang et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

Antiproliferation and apoptosis induction of paeonol in human esophageal cancer cell lines

(2008) G.-P. Sun et al.   DISEASES OF THE ESOPHAGUS

Quality control of herbal medicines by capillary electrophoresis: Potential, requirements and applications

(2008) Markus Ganzera   ELECTROPHORESIS

Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-α production

(2008) Guo-Ping Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A genome-wide microarray analysis reveals anti-inflammatory target genes of paeonol in macrophages

(2008) H. Huang et al.   INFLAMMATION RESEARCH

Advancement in analysis of Salviae miltiorrhizae Radix et Rhizoma (Danshen)

(2008) Yong-Guo Li et al.   JOURNAL OF CHROMATOGRAPHY A

Chemical fingerprinting of Liuwei Dihuang Pill and simultaneous determination of its major bioactive constituents by HPLC coupled with multiple detections of DAD, ELSD and ESI-MS

(2008) Ji Ye et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice

(2008) Shu-Zhi Zhong et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A pyrrole derivative fromPaeonia suffruticosa

(2008) K. Xiao et al.   NATURAL PRODUCT RESEARCH

Screening of Bioactive Compounds from Moutan Cortex and Their Anti-Inflammatory Activities in Rat Synoviocytes

(2007) Mengjie Wu et al.   Evidence-based Complementary and Alternative Medicine

LC–MS-based metabonomics analysis

(2007) Xin Lu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Capillary high performance liquid chromatography coupled with electrospray ionization mass spectrometry for rapid analysis of pinane monoterpene glycosides in Cortex Moutan

(2007) Yue Song et al.   JOURNAL OF SEPARATION SCIENCE

Protective effects of paeonol on cultured rat hippocampal neurons against oxygen–glucose deprivation-induced injury

(2007) Ji-biao Wu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Antioxidant properties in vitro and total phenolic contents in methanol extracts from medicinal plants

(2007) Hua-Bin Li et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor

(2006) Hua-Qing Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY