Monoterpenoid inhibitors of NO production from Paeonia suffruticosa

Three pairs of monoterpene glycosides (1-6), of which compounds 1,3, and 4 as new compounds, together with one new monoterpene (7) were obtained from the ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. On this basis, the spectral characteristics of three pairs of monoterpene glycosides were also discussed. The inhibitory effects of isolated compounds on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated, and NO production was suppressed significantly by compounds 4-7. (C) 2012 Elsevier B.V. All rights reserved.