Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics

Genotoxicity of gold nanoparticles functionalized with indolicidin towards Saccharomyces cerevisiae

(2018) Elisabetta de Alteriis et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Multigenerational effects and DNA alterations of QDs-Indolicidin on Daphnia magna

(2017) Valeria Maselli et al.   ENVIRONMENTAL POLLUTION

Host defense peptide-derived privileged scaffolds for anti-infective drug discovery

(2017) Ersilia Nigro et al.   JOURNAL OF PEPTIDE SCIENCE

Antimicrobial peptides at work: interaction of myxinidin and its mutant WMR with lipid bilayers mimicking the P. aeruginosa and E. coli membranes

(2017) Lucia Lombardi et al.   Scientific Reports

Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action

(2017) Judith Raschig et al.   PLoS Pathogens

Guardians of the Gut: Enteric Defensins

(2017) Sumathi Sankaran-Walters et al.   Frontiers in Microbiology

Bionano Interaction Study on Antimicrobial Star-Shaped Peptide Polymer Nanoparticles

(2016) Shu J. Lam et al.   ACS Applied Materials & Interfaces

Engineered Chimeric Peptides as Antimicrobial Surface Coating Agents toward Infection-Free Implants

(2016) Hilal Yazici et al.   ACS Applied Materials & Interfaces

High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells

(2016) Akhilesh Rai et al.   Acta Biomaterialia

Gold nanoparticle-DNA aptamer conjugate-assisted delivery of antimicrobial peptide effectively eliminates intracellular Salmonella enterica serovar Typhimurium

(2016) Ji-Hyun Yeom et al.   BIOMATERIALS

Antimicrobial Peptides as Anti-biofilm Agents in Medical Implants

(2016) Susana Sánchez-Gómez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Antimicrobial potentials and structural disorder of human and animal defensins

(2016) Ehab H. Mattar et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Marine Antimicrobial Peptides: Nature Provides Templates for the Design of Novel Compounds against Pathogenic Bacteria

(2016) Annarita Falanga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin

(2016) Emilia Galdiero et al.   International Journal of Nanomedicine

Enhanced stability and activity of an antimicrobial peptide in conjugation with silver nanoparticle

(2016) Indrani Pal et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Membrane Protein 4F2/CD98 Is a Cell Surface Receptor Involved in the Internalization and Trafficking of Human β-Defensin 3 in Epithelial Cells

(2015) Irene Colavita et al.   CHEMISTRY & BIOLOGY

Beyond Vancomycin: The Tail of the Lipoglycopeptides

(2015) Kenneth P. Klinker et al.   CLINICAL THERAPEUTICS

Antimicrobial Peptides as an Opportunity Against Bacterial Diseases

(2015) Stefania Galdiero et al.   CURRENT MEDICINAL CHEMISTRY

Defensins: “Simple” antimicrobial peptides or broad-spectrum molecules?

(2015) Meggy Suarez-Carmona et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata

(2015) Emilia Galdiero et al.   ENVIRONMENTAL POLLUTION

Therapeutic cyclic lipopeptides mining from microbes: latest strides and hurdles

(2015) Seema Patel et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

An ancestral host defence peptide within human β-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule

(2015) Ersilia Nigro et al.   Scientific Reports

Evidence for a Novel Mechanism of Antimicrobial Action of a Cyclic R-,W-Rich Hexapeptide

(2015) Kathi Scheinpflug et al.   PLoS One

The Chemistry and Biology of Theta Defensins

(2014) Anne C. Conibear et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Insights into and Activity Analysis of the Antimicrobial Peptide Myxinidin

(2014) Marco Cantisani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure–activity relationships of the antimicrobial peptide gramicidin S and its analogs: Aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes

(2014) Thomas Abraham et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Cyclic Cystine Ladder of Theta-Defensins as a Stable, Bifunctional Scaffold: A Proof-of-Concept Study Using the Integrin-Binding RGD Motif.

(2014) Anne C. Conibear et al.   CHEMBIOCHEM

Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish

(2013) Marco Cantisani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chimeric Beta-Defensin Analogs, Including the Novel 3NI Analog, Display Salt-Resistant Antimicrobial Activity and Lack Toxicity in Human Epithelial Cell Lines

(2013) Olga Scudiero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Defensins: Natural component of human innate immunity

(2013) Justyna Jarczak et al.   HUMAN IMMUNOLOGY

Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function

(2013) Le Zhao et al.   PLoS One

Site-Specific PEGylation of HR2 Peptides: Effects of PEG Conjugation Position and Chain Length on HIV-1 Membrane Fusion Inhibition and Proteolytic Degradation

(2012) Maarten Danial et al.   BIOCONJUGATE CHEMISTRY

θ-Defensins: Cyclic Peptides with Endless Potential: FIGURE 1.

(2012) Robert I. Lehrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Short AMP: Design and Activity Study

(2012) Yoonkyung Park et al.   PROTEIN AND PEPTIDE LETTERS

Antimicrobial peptides: agents of border protection for companion animals

(2012) Brian C. Leonard et al.   VETERINARY DERMATOLOGY

The Yin and Yang of Human Beta-Defensins in Health and Disease

(2012) Aaron Weinberg et al.   Frontiers in Immunology

Bactericidal Microparticles Decorated by an Antimicrobial Peptide for the Easy Disinfection of Sensitive Aqueous Solutions

(2011) Thomas Blin et al.   BIOMACROMOLECULES

α-Defensins in human innate immunity

(2011) Robert I. Lehrer et al.   IMMUNOLOGICAL REVIEWS

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

(2010) Fabíola Costa et al.   Acta Biomaterialia

Novel Synthetic, Salt-Resistant Analogs of Human Beta-Defensins 1 and 3 Endowed with Enhanced Antimicrobial Activity

(2010) O. Scudiero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human  -Defensin 2 and 3 and Their Mouse Orthologs Induce Chemotaxis through Interaction with CCR2

(2010) J. Rohrl et al.   JOURNAL OF IMMUNOLOGY

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

Synergistic Interaction between Silver Nanoparticles and Membrane-Permeabilizing Antimicrobial Peptides

(2009) S. Ruden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interactions of  -,  -, and  -Defensins with Influenza A Virus and Surfactant Protein D

(2009) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial activity of human beta-defensins and induction by Francisella

(2008) SuHua Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The design, structures and therapeutic potential of protein epitope mimetics

(2008) John A. Robinson et al.   DRUG DISCOVERY TODAY