Article
Pharmacology & Pharmacy
Yuanteng Zhang, Zizheng Gao, Zezheng Pan, Huangxi Fu, Feng Jiang, Hao Yan, Bo Yang, Qiaojun He, Peihua Luo, Zhifei Xu, Xiaochun Yang
Summary: This study revealed that crizotinib can cause interstitial lung disease and induce apoptosis of alveolar epithelial cells by blocking autophagic flux. It also found that metformin can reduce macrophage recruitment and pulmonary fibrosis by recovering autophagy flux, thereby improving lung damage caused by crizotinib.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sopan Shinde, Dimple Chhabria, Jaypalsing Ingle, Mohit Kumar, Sivapriya Kirubakaran, Sudipta Basu
Summary: In this study, a new small molecule library based on 3-methoxy pyrrole was synthesized and one small molecule that can localize in mitochondria and cause damage was identified through screening in colon cancer cells. This small molecule induced mitochondrial damage by generating reactive oxygen species, inhibiting anti-apoptotic protein Bcl-2 and inducing apoptosis and necrosis, leading to significant inhibition of colon cancer cell proliferation while showing minimal toxicity to normal cells. This finding provides a new direction for mitochondria-targeted colon cancer therapy research.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Ravichandran Vigneshwaran, Devaraj Ezhilarasan, Shanmugam Rajeshkumar
Summary: TiO2 synthesized with Lactobacillus shows cytotoxicity in colon cancer cells by inducing apoptosis and generating intracellular reactive oxygen species (ROS). Moreover, TiO2 causes mitochondrial damage and cytochrome c release, leading to apoptosis by activating the intrinsic apoptotic pathway.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Plant Sciences
Zhuyun Liu, Xiaoping Wu, Kun Dai, Renkai Li, Jinming Zhang, Dekuan Sheng, Simon Ming-Yuen Lee, George Pak-Heng Leung, Guo-Chun Zhou, Jingjing Li
Summary: The anti-cancer effect of AGS-30 is stronger than that of Andro, inducing apoptosis of colon cancer cells through ROS/JNK-dependent pathway. These findings may provide insights for the future development of derivatives of Andro as novel chemotherapeutic agents.
Article
Cell Biology
Hsin-Ling Yang, Hui-Wen Liu, Sirjana Shrestha, Varadharajan Thiyagarajan, Hui-Chi Huang, You-Cheng Hseu
Summary: The traditional Chinese medicinal fungus Antrodia salmonea (AS) exhibits significant anti-cancer activity in colon cancer cells by inducing apoptosis and autophagy mechanisms mediated through reactive oxygen species (ROS).
Article
Oncology
Ho Soo Yoo, Sae Bom Won, Young Hye Kwon
Summary: The study suggests that luteolin inhibits the growth of colon cancer cells through enhancing p53 activity to induce apoptosis and cell cycle arrest in a p53-dependent manner, regardless of the induction of autophagy.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Gulcin Yavuz Turel, Nilufer Sahin Calapoglu, Dilek Bayram, Meltem Ozgocmen, Vehbi Atahan Togay, Eda Evgen Tuluceoglu
Summary: The study demonstrated that curcumin has inhibitory effects on cell proliferation and induces apoptosis in colon carcinoma cells. It suggests that curcumin could be a potential protective or treatment agent against colon cancer, but further research on curcumin-rich diets and bioavailability is needed.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Plant Sciences
Ying Chen, Hisao-Hsien Wang, Hsin-Han Chang, Yun-Hsuan Huang, Jeffrey R. Wang, Chih-Ying Changchien, Sheng-Tang Wu
Summary: The study demonstrated the anticancer effects of E-isomer GS in human bladder cancer cell lines of different grades through cell cycle regulation, apoptosis, autophagy, and other mechanisms. Additionally, GS reduced cell migration ability and inhibited tumor growth.
Article
Oncology
Bou-Yue Peng, Abhinay Kumar Singh, Chun-Hao Chan, Yue-Hua Deng, Pin-Ying Li, Chun-Wei Su, Chia-Yu Wu, Win-Ping Deng
Summary: In this study, the researchers found that AGA has the potential to inhibit colon cancer by inhibiting proliferation, migration, and cell cycle kinase through upregulating p21 protein expression and promoting apoptotic protein in a p53-dependent and independent manner.
Article
Oncology
Hao Wang, Yingxing Xu, Jialin Sun, Zhongguo Sui
Summary: In this study, the novel curcumin derivative 1g was found to inhibit tumor growth in colon cancer cells by inducing apoptosis through mechanisms such as changes in mitochondrial membrane potential, enhanced pro-apoptotic activity, and ROS production. These findings suggest that targeted strategies based on ROS could be a promising approach to inhibit colon cancer proliferation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi-Ting Chen, Tzu-Ting Tseng, Hung-Pei Tsai, Ming-Yii Huang
Summary: Arylquin 1 exhibits anticancer effects in colorectal cancer cells by inhibiting cell proliferation, migration, and invasion, and inducing apoptosis. It increases the phosphorylation levels of ERK, JNK, and p38, which are related to key signaling proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yanhong Wang, Xinyu Mang, Xuran Li, Zhengyu Cai, Fei Tan
Summary: This study investigated the effect and mechanism of cold atmospheric plasma (CAP) on the proliferation and apoptosis of lung cancer and colon cancer cells. The results showed that CAP treatment inhibited tumor cell proliferation and induced apoptosis through the activation of the mitochondrial pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thi Yen Ly Huynh, Ilona Oscilowska, Lukasz Szoka, Ewelina Piktel, Weronika Baszanowska, Katarzyna Bielawska, Robert Bucki, Wojciech Miltyk, Jerzy Palka
Summary: The effect of metformin (MET) on PRODH/POX-dependent apoptosis was studied in wild-type MCF-7 cells and POX knockdown MCF-7 cells. MET was found to increase prolidase activity and decrease collagen biosynthesis, resulting in an increase in substrate concentration for PRODH/POX-dependent ROS formation and caspases activation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Ravshan Burikhanov, Saptadwipa Ganguly, Sally Ellingson, Vitaliy M. Sviripa, Nathalia Araujo, Shunqiang Li, Prasanna Venkatraman, Mahadev Rao, Anuradha Choughule, Christine F. Brainson, Chang-Guo Zhan, H. Peter Spielmann, David S. Watt, Ramaswamy Govindan, Vivek M. Rangnekar
Summary: Lung cancer cells develop resistance to apoptosis by suppressing the secretion of Par-4 protein and/or downmodulating the Par-4 receptor GRP78. The FDA-approved drug crizotinib (CZT) was found to elevate GRP78 expression in lung cancer cells and induce Par-4 secretion from normal cells. CZT activates SRC in normal cells, leading to Par-4 secretion, while inhibiting SRC activation in cancer cells prevents GRP78 translocation but promotes Par-4 secretion. This differential activation of SRC by CZT can be used to target csGRP78 and inhibit ALK-negative lung tumors.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shanbin Chen, Dong Zhao, Chunguang Luan, Jia Zheng, Wei Liu, Zheng Feng, Ruiqi Luo, Xinglin Han, Deliang Wang
Summary: This study investigated the potential role of ferulic acid (FA) as a means of inducing apoptosis and inhibiting colon cancer induced by CT26 cells. The results showed that FA adjuvant treatment upregulated autophagy-related gene expression, suppressed inflammatory response elements expression, and improved bodyweight, ALT, and AST levels. Furthermore, FA inhibited CT26 cell proliferation and induced apoptosis by activating the phosphorylation of ERK and JNK to enhance BCL-2 and BAX proteins in the apoptosis pathway. These findings suggest that FA could be a promising auxiliary therapeutic agent for colon cancer.
Article
Oncology
Jingshan Tong, Xiao Tan, Xiangping Song, Man Gao, Denise Risnik, Suisui Hao, Kaylee Ermine, Peng Wang, Hua Li, Yi Huang, Jian Yu, Lin Zhang
Summary: This study found that CDK4/6 inhibitors promote immunogenic cell death of cancer cells by regulating the expression of p73 and DR5, enhancing the effects of chemotherapy and immune therapy.
Article
Oncology
Chaoyuan Kuang, Jingshan Tong, Kaylee Ermine, Manbo Cai, Fujun Dai, Suisui Hao, Francis Giles, Yi Huang, Jian Yu, Lin Zhang
Summary: The study demonstrates that NEO2734 more potently suppresses CRC cell growth than first generation BET inhibitors, inducing CRC cell apoptosis via both the intrinsic and extrinsic pathways. NEO2734 treatment simultaneously upregulates PUMA and DR5 to induce cell death, effectively suppressing CRC growth.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingshan Tong, Xiao Tan, Suisui Hao, Kaylee Ermine, Xinyan Lu, Zhaojin Liu, Anupma Jha, Jian Yu, Lin Zhang
Summary: Targeting cyclin-dependent kinases (CDKs) has shown promising therapeutic potential against cancer. A recent study reveals that selective CDK4/6 inhibitors induce Death Receptor 5 (DR5) via p73, leading to increased sensitivity of colorectal cancer cells to therapy-induced apoptosis. This finding provides valuable insights into the anticancer mechanisms of CDKIs and their potential clinical applications in colorectal cancer.
Article
Multidisciplinary Sciences
Suisui Hao, Jingshan Tong, Anupma Jha, Denise Risnik, Darleny Lizardo, Xinyan Lu, Ajay Goel, Patricia L. Opresko, Jian Yu, Lin Zhang
Summary: Synthetic lethality can be used to target oncogenic drivers in cancer, and in this study, it was found that WRN helicase is required for the survival of MSI CRC cells. Depletion of WRN induces p53 and PUMA, leading to apoptosis in MSI CRC cells. The vulnerability of MSI CRCs to WRN loss is mediated by p53/PUMA-dependent apoptosis. WRN depletion or treatment with ML216 suppresses the growth of MSI CRCs in vitro and in vivo in a p53/PUMA-dependent manner.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Kaylee Ermine, Jian Yu, Lin Zhang
Summary: The RIP kinase family plays a crucial role in cell survival and cell death signaling. Dysregulation of RIP kinases is associated with various pathological conditions including inflammatory diseases, neurological diseases, and cancer. Alterations of RIP kinases in cancer cells contribute to tumor progression, therapeutic resistance, and escape from immune response. Targeting RIP kinases has potential implications for cancer treatment.
Article
Biochemistry & Molecular Biology
Brian J. Leibowitz, Guangyi Zhao, Wenxin Xia, Yuhan Wang, Hang Ruan, Lin Zhang, Jian Yu
Summary: In this study, the researchers discovered that mTOR inhibition can effectively suppress the formation of intestinal polyps, reverse established polyps, and prolong the lifespan of APC(Min/+) mice. Everolimus reduces the levels of p-4EBP1, p-S6, and Myc in the polyps and induces apoptosis of cells with activated beta-catenin. This cell death is accompanied by ER stress, activation of the extrinsic apoptotic pathway, innate immune cell recruitment, and subsequent T-cell infiltration.
Article
Oncology
Diala F. Hamade, Michael W. Epperly, Renee Fisher, Wen Hou, Donna Shields, Jan-Peter van Pijkeren, Amitava Mukherjee, Jian Yu, Brian J. Leibowitz, Anda M. Vlad, Lan Coffman, Hong Wang, M. Saiful Huq, Ziyu Huang, Claude J. Rogers, Joel S. Greenberger
Summary: Irradiation can be an effective treatment for ovarian cancer, but its use is limited by intestinal toxicity. Strategies to mitigate toxicity are important and LR-IFN-beta, a genetically engineered probiotic, shows potential as a safe and feasible radiation mitigator. LR-IFN-beta protects the intestine, improves survival, and can potentially revolutionize OC patient management when combined with platinum/taxane-based chemotherapy.
Review
Pharmacology & Pharmacy
Haris Saeed, Brian J. Leibowitz, Lin Zhang, Jian Yu
Summary: MYC is a proto-oncogene that plays a crucial role in the development of cancer cells. It is frequently rearranged and amplified in hematologic malignancies and is associated with cancer progression and therapeutic resistance. Activation of specific signaling pathways increases Myc levels, leading to stress adaptation, metabolic reprogramming, and immune evasion. Targeting Myc has proven challenging, but recent advances in understanding its mechanisms have opened up potential strategies for treatment, especially in colorectal cancer.
DRUG RESISTANCE UPDATES
(2023)
Meeting Abstract
Oncology
Kaylee Ermine, Dongshi Chen, Peng Wang, Jian Yu, Lin Zhang
Meeting Abstract
Oncology
Bogdan Kochetov, Phoenix D. Bell, Rebecca Raphael, Benjamin J. Raymond, Brian J. Leibowitz, Jingshan Tong, Brenda Diergaarde, Jian Yu, Reetesh K. Pai, Robert E. Schoen, Lin Zhang, Aatur Singhi, Shikhar Uttam.
Meeting Abstract
Oncology
Kaylee A. Ermine, Dongshi Chen, Peng Wang, Jian Yu, Lin Zhang
Article
Biochemistry & Molecular Biology
Hang Ruan, Brian J. Leibowitz, Yingpeng Peng, Lin Shen, Lujia Chen, Charlie Kuang, Robert E. Schoen, Xinghua Lu, Lin Zhang, Jian Yu
Summary: Mutant KRAS plays a crucial role in colorectal cancer by promoting Myc translation and Myc-dependent stress adaptation and proliferation. The combination of two FDA-approved drugs, Bortezomib and Everolimus, has been found to be highly effective against mutant KRAS colorectal cancer cells. This combination rapidly depletes Myc protein and induces cell death through various pathways. The study also shows that mutant KRAS colorectal cancer cells with elevated basal Myc and p-eIF2 alpha are more sensitive to the BR combination and exhibit characteristics of stress adaptation and cell death.
MOLECULAR BIOMEDICINE
(2022)