Journal
MOLECULES
Volume 16, Issue 11, Pages 9368-9385Publisher
MDPI
DOI: 10.3390/molecules16119368
Keywords
antitumor activities; indolin-2-one; chloropyrrole; synthesis
Funding
- Fund of Science and Technology Development, Shanghai, China [054319907, 09431901400]
Ask authors/readers for more resources
Eighteen novel 3-substituted-indolin-2-ones containing chloropyrroles were synthesized and their biological activities were evaluated. The presence of a chlorine atom on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethyl-amino)ethylcarbamoyl group as a substituent at the C-4' position of the pyrrole enhanced the antitumor activities notably. IC50 values as low as 0.32, 0.67, 1.19 and 1.22 mu M were achieved against non-small cell lung cancer (A549), oral epithelial (KB), melanoma (K111) and large cell lung cancer cell lines (NCI-H460), respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available