Gene editing as applied to prevention of reproductive porcine reproductive and respiratory syndrome

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

(2017) Christine Burkard et al.   PLoS Pathogens

What is CRISPR/Cas9?

(2016) Melody Redman et al.   Archives of Disease in Childhood-Education and Practice Edition

Genome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetus

(2016) Jamie M. Wilkinson et al.   BMC GENOMICS

Zygote injection of CRISPR/Cas9 RNA successfully modifies the target gene without delaying blastocyst development or altering the sex ratio in pigs

(2016) Kristin M. Whitworth et al.   TRANSGENIC RESEARCH

Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis

(2016) Shuaifeng Li et al.   Oncotarget

One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system

(2016) Xianlong Wang et al.   Scientific Reports

Induction of Apoptosis by the Nonstructural Protein 4 and 10 of Porcine Reproductive and Respiratory Syndrome Virus

(2016) Shuaizhen Yuan et al.   PLoS One

PRRSV receptors and their roles in virus infection

(2015) Chongxu Shi et al.   ARCHIVES OF MICROBIOLOGY

Transcriptome Analysis of PigIn Vivo,In Vitro–Fertilized, and Nuclear Transfer Blastocyst-Stage Embryos Treated with Histone Deacetylase Inhibitors Postfusion and Activation Reveals Changes in the Lysosomal Pathway

(2015) Kristin M. Whitworth et al.   Cellular Reprogramming

Evolutionary diversification of type 2 porcine reproductive and respiratory syndrome virus

(2015) Manreetpal Singh Brar et al.   JOURNAL OF GENERAL VIROLOGY

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus

(2015) Kristin M Whitworth et al.   NATURE BIOTECHNOLOGY

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

PRRS virus receptors and their role for pathogenesis

(2015) Qingzhan Zhang et al.   VETERINARY MICROBIOLOGY

Pathogenicity of three type 2 porcine reproductive and respiratory syndrome virus strains in experimentally inoculated pregnant gilts

(2015) Andrea Ladinig et al.   VIRUS RESEARCH

Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs

(2015) Xianlong Wang et al.   Scientific Reports

Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos1

(2014) Kristin M. Whitworth et al.   BIOLOGY OF REPRODUCTION

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

(2014) Tang Hai et al.   CELL RESEARCH

Pig blastocyst–uterine interactions

(2014) Fuller W. Bazer et al.   DIFFERENTIATION

Mapping the Global Distribution of Livestock

(2014) Timothy P. Robinson et al.   PLoS One

Variation in Fetal Outcome, Viral Load and ORF5 Sequence Mutations in a Large Scale Study of Phenotypic Responses to Late Gestation Exposure to Type 2 Porcine Reproductive and Respiratory Syndrome Virus

(2014) Andrea Ladinig et al.   PLoS One

An Intact Sialoadhesin (Sn/SIGLEC1/CD169) Is Not Required for Attachment/Internalization of the Porcine Reproductive and Respiratory Syndrome Virus

(2013) R. S. Prather et al.   JOURNAL OF VIROLOGY

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Molecular evolution of PRRSV in Europe: Current state of play

(2013) Tomasz Stadejek et al.   VETERINARY MICROBIOLOGY

Pathogenesis of type 1 (European genotype) porcine reproductive and respiratory syndrome virus in male gonads of infected boar

(2013) K. Han et al.   VETERINARY RESEARCH COMMUNICATIONS

Comparative pathogenesis of type 1 (European genotype) and type 2 (North American genotype) porcine reproductive and respiratory syndrome virus in infected boar

(2013) Kiwon Han et al.   Virology Journal

RNA-guided genetic silencing systems in bacteria and archaea

(2012) Blake Wiedenheft et al.   NATURE

Macrophage Phenotype Modulation by CXCL4 in Atherosclerosis

(2012) Christian A. Gleissner   Frontiers in Physiology

CRISPR-based adaptive immune systems

(2011) Michael P Terns et al.   CURRENT OPINION IN MICROBIOLOGY

Porcine reproductive and respiratory syndrome virus (PRRSV) causes apoptosis during its replication in fetal implantation sites

(2011) Uladzimir U. Karniychuk et al.   MICROBIAL PATHOGENESIS

Interaction of the Cas6 Riboendonuclease with CRISPR RNAs: Recognition and Cleavage

(2011) Ruiying Wang et al.   STRUCTURE

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage

(2010) W. Van Breedam et al.   JOURNAL OF GENERAL VIROLOGY

Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy

(2010) Hanne Van Gorp et al.   MOLECULAR IMMUNOLOGY

The interaction between PRRSV and the late gestation pig fetus

(2010) Raymond R.R. Rowland   VIRUS RESEARCH

A brief review of CD163 and its role in PRRSV infection

(2010) Siao-Kun W. Welch et al.   VIRUS RESEARCH

Molecular epidemiology of PRRSV: A phylogenetic perspective

(2010) Mang Shi et al.   VIRUS RESEARCH

Significant Improvement in Cloning Efficiency of an Inbred Miniature Pig by Histone Deacetylase Inhibitor Treatment after Somatic Cell Nuclear Transfer1

(2009) Jianguo Zhao et al.   BIOLOGY OF REPRODUCTION

Identification of the CD163 Protein Domains Involved in Infection of the Porcine Reproductive and Respiratory Syndrome Virus

(2009) H. Van Gorp et al.   JOURNAL OF VIROLOGY

Quantitative Changes of Sialoadhesin and CD163 Positive Macrophages in the Implantation Sites and Organs of Porcine Embryos/Fetuses During Gestation

(2009) U.U. Karniychuk et al.   PLACENTA

Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus

(2008) H. Van Gorp et al.   JOURNAL OF GENERAL VIROLOGY

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

(2008) Luciano A. Marraffini et al.   SCIENCE