Zygote injection of CRISPR/Cas9 RNA successfully modifies the target gene without delaying blastocyst development or altering the sex ratio in pigs

Large animal models of cardiovascular disease

(2016) H. G. Tsang et al.   CELL BIOCHEMISTRY AND FUNCTION

The production of multi-transgenic pigs: update and perspectives for xenotransplantation

(2016) Heiner Niemann et al.   TRANSGENIC RESEARCH

Mammalian interspecies substitution of immune modulatory alleles by genome editing

(2016) Simon G. Lillico et al.   Scientific Reports

PS48 can replace bovine serum albumin in pig embryo culture medium, and improve in vitro embryo development by phosphorylating AKT

(2015) Lee D. Spate et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus

(2015) Kristin M Whitworth et al.   NATURE BIOTECHNOLOGY

Arginine increases development of in vitro-produced porcine embryos and affects the protein arginine methyltransferase–dimethylarginine dimethylaminohydrolase–nitric oxide axis

(2015) Bethany K. Redel et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs

(2015) Xianlong Wang et al.   Scientific Reports

Production of Human Albumin in Pigs Through CRISPR/Cas9-Mediated Knockin of Human cDNA into Swine Albumin Locus in the Zygotes

(2015) Jin Peng et al.   Scientific Reports

CRISPR/Cas9 as Tool for Functional Study of Genes Involved in Preimplantation Embryo Development

(2015) Jeongwoo Kwon et al.   PLoS One

Double Transgenic Pigs with Combined Expression of Human α1,2-Fucosyltransferase and α-Galactosidase Designed to Avoid Hyperacute Xenograft Rejection

(2014) Joanna Zeyland et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos1

(2014) Kristin M. Whitworth et al.   BIOLOGY OF REPRODUCTION

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

(2014) Tang Hai et al.   CELL RESEARCH

TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice

(2014) C. Tarnow et al.   JOURNAL OF VIROLOGY

The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses

(2014) K. Sakai et al.   JOURNAL OF VIROLOGY

Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection

(2014) Ping Li et al.   XENOTRANSPLANTATION

An Intact Sialoadhesin (Sn/SIGLEC1/CD169) Is Not Required for Attachment/Internalization of the Porcine Reproductive and Respiratory Syndrome Virus

(2013) R. S. Prather et al.   JOURNAL OF VIROLOGY

Energy substrate influences the effect of the timing of the first embryonic cleavage on the development of in vitro-produced porcine embryos in a sex-related manner

(2013) Eva Torner et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice

(2013) Bastian Hatesuer et al.   PLoS Pathogens

Piglets produced from cloned blastocysts cultured in vitro with GM-CSF

(2012) Kiho Lee et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

A Cloned Pig Model for Examining Atherosclerosis Induced by High Fat, High Cholesterol Diets

(2010) Tor W. Jensen et al.   ANIMAL BIOTECHNOLOGY

Transcriptional Profiling by Deep Sequencing Identifies Differences in mRNA Transcript Abundance in In Vivo-Derived Versus In Vitro-Cultured Porcine Blastocyst Stage Embryos1

(2010) Bethany K. Bauer et al.   BIOLOGY OF REPRODUCTION

Glucose Intolerance and Reduced Proliferation of Pancreatic  -Cells in Transgenic Pigs With Impaired Glucose-Dependent Insulinotropic Polypeptide Function

(2010) S. Renner et al.   DIABETES

Activation method does not alter abnormal placental gene expression and development in cloned pigs

(2010) Kristin M. Whitworth et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

The Role of Swine in the Generation of Novel Influenza Viruses

(2009) W. Ma et al.   Zoonoses and Public Health

Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer

(2008) Christopher S. Rogers et al.   JOURNAL OF CLINICAL INVESTIGATION