Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

(2017) James D McKay et al.   NATURE GENETICS

Association of the DBH Polymorphism rs3025343 With Smoking Cessation in a Large Population-Based Sample

(2017) Katariina Hirvonen et al.   NICOTINE & TOBACCO RESEARCH

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

(2017) Paul S. de Vries et al.   PLoS One

Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations

(2016) Matthew T. Sutherland et al.   Behavioral and Brain Functions

The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants

(2016) João Fadista et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set

(2016) Masahiro Kanai et al.   JOURNAL OF HUMAN GENETICS

A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences

(2016) T E Thorgeirsson et al.   MOLECULAR PSYCHIATRY

Weighting sequence variants based on their annotation increases power of whole-genome association studies

(2016) Gardar Sveinbjornsson et al.   NATURE GENETICS

Have we been ignoring the elephant in the room? Seven arguments for considering the cerebellum as part of addiction circuitry

(2016) Marta Miquel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans

(2015) Joel Gelernter et al.   BIOLOGICAL PSYCHIATRY

A multiancestry study identifies novel genetic associations withCHRNA5methylation in human brain and risk of nicotine dependence

(2015) Dana B. Hancock et al.   HUMAN MOLECULAR GENETICS

Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci

(2015) Eilis Hannon et al.   NATURE NEUROSCIENCE

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence

(2015) D B Hancock et al.   Translational Psychiatry

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

(2015) Louise V Wain et al.   Lancet Respiratory Medicine

Time to First Morning Cigarette and Risk of Chronic Obstructive Pulmonary Disease: Smokers in the PLCO Cancer Screening Trial

(2015) Kristin A. Guertin et al.   PLoS One

Regulatory Polymorphisms in Human DBH Affect Peripheral Gene Expression and Sympathetic Activity

(2014) Elizabeth S. Barrie et al.   CIRCULATION RESEARCH

Time to Smoke First Morning Cigarette and Lung Cancer in a Case–Control Study

(2014) Fangyi Gu et al.   JNCI-Journal of the National Cancer Institute

The contribution of rare and common variants in 30 genes to risk nicotine dependence

(2014) J Yang et al.   MOLECULAR PSYCHIATRY

Genetic variability in the regulation of gene expression in ten regions of the human brain

(2014) Adaikalavan Ramasamy et al.   NATURE NEUROSCIENCE

Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer

(2014) I Teneng et al.   ONCOGENE

Abnormalities of the DNA Methylation Mark and Its Machinery: An Emerging Cause of Neurologic Dysfunction

(2014) Jacqueline Weissman et al.   SEMINARS IN NEUROLOGY

The cerebellum and addiction: insights gained from neuroimaging research

(2013) Eric A. Moulton et al.   ADDICTION BIOLOGY

Indirectly estimated absolute lung cancer mortality rates by smoking status and histological type based on a systematic review

(2013) Peter N Lee et al.   BMC CANCER

Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample

(2013) A Loukola et al.   MOLECULAR PSYCHIATRY

Imputation of Variants from the 1000 Genomes Project Modestly Improves Known Associations and Can Identify Low-frequency Variant - Phenotype Associations Undetected by HapMap Based Imputation

(2013) Andrew R. Wood et al.   PLoS One

Cis-Regulatory Variants Affect CHRNA5 mRNA Expression in Populations of African and European Ancestry

(2013) Jen-Chyong Wang et al.   PLoS One

CHRNB3 is more strongly associated with Fagerström Test for Cigarette Dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results

(2012) John P. Rice et al.   ADDICTION

Systematic review with meta-analysis of the epidemiological evidence in the 1900s relating smoking to lung cancer

(2012) Peter N Lee et al.   BMC CANCER

1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data

(2012) Jie Huang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Characteristics and smoking patterns of intermittent smokers.

(2012) Saul Shiffman et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Genome-wide meta-analyses of smoking behaviors in African Americans

(2012) S P David et al.   Translational Psychiatry

DSM criteria for tobacco use disorder and tobacco withdrawal: a critique and proposed revisions for DSM-5*

(2011) Timothy B. Baker et al.   ADDICTION

Rare Nonsynonymous Variants in Alpha-4 Nicotinic Acetylcholine Receptor Gene Protect Against Nicotine Dependence

(2011) Pingxing Xie et al.   BIOLOGICAL PSYCHIATRY

Brain grey matter deficits in smokers: focus on the cerebellum

(2011) Simone Kühn et al.   Brain Structure & Function

Forest Plot Viewer

(2011) Abee L. Boyles et al.   EPIDEMIOLOGY

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications

(2011) Rita Z. Goldstein et al.   NATURE REVIEWS NEUROSCIENCE

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

(2011) L. D. Ward et al.   NUCLEIC ACIDS RESEARCH

Genome-wide association study of smoking behaviours in patients with COPD

(2011) M. Siedlinski et al.   THORAX

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

(2010) Thorgeir E Thorgeirsson et al.   NATURE GENETICS

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

(2010) Jason Z Liu et al.   NATURE GENETICS

Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain

(2010) J. Raphael Gibbs et al.   PLoS Genetics

Cerebellum and Nonmotor Function

(2009) Peter L. Strick et al.   Annual Review of Neuroscience

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

(2009) Jen C. Wang et al.   HUMAN MOLECULAR GENETICS

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants

(2008) Itsik Pe'er et al.   GENETIC EPIDEMIOLOGY

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

(2008) Thorgeir E. Thorgeirsson et al.   NATURE

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

(2008) Christopher I Amos et al.   NATURE GENETICS