The HCPro from the Potyviridae family: an enviable multitasking Helper Component that every virus would like to have

Characterization of a new cucurbit-infecting ipomovirus from Sudan

(2016) Cécile Desbiez et al.   ARCHIVES OF VIROLOGY

Analysis of the complete genome sequence of euphorbia ringspot virus, an atypical member of the genus Potyvirus

(2016) Dennis Knierim et al.   ARCHIVES OF VIROLOGY

The P1N-PISPOtrans-Frame Gene of Sweet Potato Feathery Mottle Potyvirus Is Produced during Virus Infection and Functions as an RNA Silencing Suppressor

(2016) Ares Mingot et al.   JOURNAL OF VIROLOGY

Protein composition of 6K2-induced membrane structures formed duringPotato virus Ainfection

(2016) Andres Lõhmus et al.   MOLECULAR PLANT PATHOLOGY

A novel sweet potato potyvirus open reading frame (ORF) is expressed via polymerase slippage and suppresses RNA silencing

(2016) Milton Untiveros et al.   MOLECULAR PLANT PATHOLOGY

Developmental Defects Mediated by the P1/HC-Pro Potyviral Silencing Suppressor Are Not Due to Misregulation of AUXIN RESPONSE FACTOR 8

(2016) Sizolwenkosi Mlotshwa et al.   PLANT PHYSIOLOGY

Mobile small RNAs regulate genome-wide DNA methylation

(2016) Mathew G. Lewsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HC-Pro viral suppressor from tobacco vein banding mosaic virus interferes with DNA methylation and activates the salicylic acid pathway

(2016) Liping Yang et al.   VIROLOGY

Truncated yet functional viral protein produced via RNA polymerase slippage implies underestimated coding capacity of RNA viruses

(2016) Yuka Hagiwara-Komoda et al.   Scientific Reports

Transcriptional slippage in the positive-sense RNA virus family Potyviridae

(2015) A. Olspert et al.   EMBO REPORTS

RNA Polymerase Slippage as a Mechanism for the Production of Frameshift Gene Products in Plant Viruses of the Potyviridae Family

(2015) Bernardo Rodamilans et al.   JOURNAL OF VIROLOGY

Recombination of strain O segments to HCpro-encoding sequence of strain N ofPotato virus Ymodulates necrosis induced in tobacco and in potatoes carrying resistance genesNyorNc

(2015) Yan-Ping Tian et al.   MOLECULAR PLANT PATHOLOGY

Mycoreovirus genome rearrangements associated with RNA silencing deficiency

(2015) Ana Eusebio-Cope et al.   NUCLEIC ACIDS RESEARCH

Twenty years of theMEROPSdatabase of proteolytic enzymes, their substrates and inhibitors

(2015) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Helper component-proteinase enhances the activity of 1-deoxy-D-xylulose-5-phosphate synthase and promotes the biosynthesis of plastidic isoprenoids in Potato virus Y-infected tobacco

(2015) Heng Li et al.   PLANT CELL AND ENVIRONMENT

Molecular insights into the function of the viral RNA silencing suppressor HCPro

(2015) Konstantin I. Ivanov et al.   PLANT JOURNAL

Potato virus Y HC-Pro Reduces the ATPase Activity of NtMinD, Which Results in Enlarged Chloroplasts in HC-Pro Transgenic Tobacco

(2015) Yayi Tu et al.   PLoS One

The amino acid 419 in HC-Pro is involved in the ability of PVY isolate N605 to induce necrotic symptoms on potato tubers

(2015) Laurent Glais et al.   VIRUS RESEARCH

Multiple functions of capsid proteins in (+) stranded RNA viruses during plant–virus interactions

(2015) Philipp H. Weber et al.   VIRUS RESEARCH

Interaction between PVY HC-Pro and the NtCF1β-subunit reduces the amount of chloroplast ATP synthase in virus-infected tobacco

(2015) Yayi Tu et al.   Scientific Reports

Viral factors involved in plant pathogenesis

(2015) Juan Antonio García et al.   Current Opinion in Virology

Formation of Potato Virus A-Induced RNA Granules and Viral Translation Are Interrelated Processes Required for Optimal Virus Accumulation

(2015) Anders Hafrén et al.   PLoS Pathogens

Roles and Programming of Arabidopsis ARGONAUTE Proteins during Turnip Mosaic Virus Infection

(2015) Hernan Garcia-Ruiz et al.   PLoS Pathogens

Biogenesis, Function, and Applications of Virus-Derived Small RNAs in Plants

(2015) Chao Zhang et al.   Frontiers in Microbiology

Localizing Viruses in Their Insect Vectors

(2014) Stéphane Blanc et al.   Annual Review of Phytopathology

The Diversity, Biogenesis, and Activities of Endogenous Silencing Small RNAs inArabidopsis

(2014) Nicolas G. Bologna et al.   Annual Review of Plant Biology

The asparagine residue in the FRNK box of potyviral helper-component protease is critical for its small RNA binding and subcellular localization

(2014) N. Sahana et al.   JOURNAL OF GENERAL VIROLOGY

A Novel Role of the Potyviral Helper Component Proteinase Contributes To Enhance the Yield of Viral Particles

(2014) A. Valli et al.   JOURNAL OF VIROLOGY

trans-Protease Activity and Structural Insights into the Active Form of the Alphavirus Capsid Protease

(2014) M. Aggarwal et al.   JOURNAL OF VIROLOGY

Potato virus Y HCPro Localization at Distinct, Dynamically Related and Environment-Influenced Structures in the Cell Cytoplasm

(2014) Francisco del Toro et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The Potyviridae Cylindrical Inclusion Helicase: A Key Multipartner and Multifunctional Protein

(2014) M. Sorel et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Ipomovirus - an atypical genus in the familyPotyviridaetransmitted by whiteflies

(2014) Aviv Dombrovsky et al.   PEST MANAGEMENT SCIENCE

The long and short of antiviral defense: small RNA-based immunity in insects

(2014) Alfred W Bronkhorst et al.   Current Opinion in Virology

The Hypervariable Amino-Terminus of P1 Protease Modulates Potyviral Replication and Host Defense Responses

(2014) Fabio Pasin et al.   PLoS Pathogens

Molecular Evolution of Viral Multifunctional Proteins: The Case of Potyvirus HC-Pro

(2013) Beata Hasiów-Jaroszewska et al.   JOURNAL OF MOLECULAR EVOLUTION

Involvement of Viral MicroRNA in the Regulation of Antiviral Apoptosis in Shrimp

(2013) T. Huang et al.   JOURNAL OF VIROLOGY

Fitness penalty in susceptible host is associated with virulence ofSoybean mosaic virusonRsv1-genotype soybean: a consequence of perturbation of HC-Pro and not P3

(2013) B. Khatabi et al.   MOLECULAR PLANT PATHOLOGY

Unrelated viral suppressors of RNA silencing mediate the control of ARGONAUTE1 level

(2013) Éva Várallyay et al.   MOLECULAR PLANT PATHOLOGY

Mutation of a Short Variable Region in HCpro Protein of Potato virus A Affects Interactions with a Microtubule-Associated Protein and Induces Necrotic Responses in Tobacco

(2013) Tuuli Haikonen et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Interaction of the Microtubule-Associated Host Protein HIP2 with Viral Helper Component Proteinase Is Important in Infection with Potato virus A

(2013) Tuuli Haikonen et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Effects of the Crinivirus Coat Protein–Interacting Plant Protein SAHH on Post-Transcriptional RNA Silencing and Its Suppression

(2013) M. Carmen Cañizares et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

(2013) Stephane E. Castel et al.   NATURE REVIEWS GENETICS

RNA Interference Pathways in Fungi: Mechanisms and Functions

(2012) Shwu-Shin Chang et al.   Annual Review of Microbiology

Complete nucleotide sequence and construction of an infectious clone of Chinese yam necrotic mosaic virus suggest that macluraviruses have the smallest genome among members of the family Potyviridae

(2012) Toru Kondo et al.   ARCHIVES OF VIROLOGY

Heterologous RNA-silencing suppressors from both plant- and animal-infecting viruses support plum pox virus infection

(2012) V. I. Maliogka et al.   JOURNAL OF GENERAL VIROLOGY

Non-canonical translation in RNA viruses

(2012) A. E. Firth et al.   JOURNAL OF GENERAL VIROLOGY

Identification of new Potato virus Y (PVY) molecular determinants for the induction of vein necrosis in tobacco

(2012) FLORENCE FAUREZ et al.   MOLECULAR PLANT PATHOLOGY

Eukaryotic translation initiation factor 4E-mediated recessive resistance to plant viruses and its utility in crop improvement

(2012) AIMING WANG et al.   MOLECULAR PLANT PATHOLOGY

Genetic Determinants of Potato virus Y Required to Overcome or Trigger Hypersensitive Resistance to PVY Strain Group O Controlled by the Gene Ny in Potato

(2012) Yan-Ping Tian et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The HC-Pro and P3 Cistrons of an Avirulent Soybean mosaic virus Are Recognized by Different Resistance Genes at the Complex Rsv1 Locus

(2012) R.-H. Wen et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Inhibition of the Host Proteasome Facilitates Papaya Ringspot Virus Accumulation and Proteosomal Catalytic Activity Is Modulated by Viral Factor HcPro

(2012) Nandita Sahana et al.   PLoS One

Tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors

(2012) K. S. Nakahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triticum mosaic poacevirus enlists P1 rather than HC-Pro to suppress RNA silencing-mediated host defense

(2012) Satyanarayana Tatineni et al.   VIROLOGY

Phylogenetic relationships of closely related potyviruses infecting sweet potato determined by genomic characterization of Sweet potato virus G and Sweet potato virus 2

(2012) Fan Li et al.   VIRUS GENES

Tritimovirus P1 functions as a suppressor of RNA silencing and an enhancer of disease symptoms

(2012) Brock A. Young et al.   VIRUS RESEARCH

HC-Pro silencing suppressor significantly alters the gene expression profile in tobacco leaves and flowers

(2011) Arto J Soitamo et al.   BMC PLANT BIOLOGY

Mobile 24 nt Small RNAs Direct Transcriptional Gene Silencing in the Root Meristems of Arabidopsis thaliana

(2011) Charles W. Melnyk et al.   CURRENT BIOLOGY

Structure of the Autocatalytic Cysteine Protease Domain of Potyvirus Helper-component Proteinase

(2011) Bihong Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of plum pox potyviral protein-protein interactions in planta using an optimized mRFP-based bimolecular fluorescence complementation system

(2011) E. Zilian et al.   JOURNAL OF GENERAL VIROLOGY

The helper component-proteinase of the Zucchini yellow mosaic virus inhibits the Hua Enhancer 1 methyltransferase activity in vitro

(2011) R. M. Jamous et al.   JOURNAL OF GENERAL VIROLOGY

Differences in the mechanism of inoculation between a semi-persistent and a non-persistent aphid-transmitted plant virus

(2011) A. Moreno et al.   JOURNAL OF GENERAL VIROLOGY

Helper Component Proteinase of the Genus Potyvirus Is an Interaction Partner of Translation Initiation Factors eIF(iso)4E and eIF4E and Contains a 4E Binding Motif

(2011) M. Ala-Poikela et al.   JOURNAL OF VIROLOGY

Top 10 plant viruses in molecular plant pathology

(2011) KAREN-BETH G. SCHOLTHOF et al.   MOLECULAR PLANT PATHOLOGY

The Helper Component Proteinase Cistron ofPotato virus YInduces Hypersensitivity and Resistance in Potato Genotypes Carrying Dominant Resistance Genes on Chromosome IV

(2011) Benoît Moury et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The Cucumber vein yellowing virus Silencing Suppressor P1b Can Functionally Replace HCPro in Plum pox virus Infection in a Host-Specific Manner

(2011) Alberto Carbonell et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Sweetpotato Viruses: 15 Years of Progress on Understanding and Managing Complex Diseases

(2011) Christopher A. Clark et al.   PLANT DISEASE

The specific binding to 21-nt double-stranded RNAs is crucial for the anti-silencing activity of Cucumber vein yellowing virus P1b and perturbs endogenous small RNA populations

(2011) A. Valli et al.   RNA

Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network

(2011) M. S. Mukhtar et al.   SCIENCE

Subgenomic messenger RNAs: Mastering regulation of (+)-strand RNA virus life cycle

(2011) Joanna Sztuba-Solińska et al.   VIROLOGY

Misregulation of AUXIN RESPONSE FACTOR 8 Underlies the Developmental Abnormalities Caused by Three Distinct Viral Silencing Suppressors in Arabidopsis

(2011) Florence Jay et al.   PLoS Pathogens

A single amino acid change in HC-Pro of soybean mosaic virus alters symptom expression in a soybean cultivar carrying Rsv1 and Rsv3

(2010) Jang-Kyun Seo et al.   ARCHIVES OF VIROLOGY

The helper-component protease transmission factor of tobacco etch potyvirus binds specifically to an aphid ribosomal protein homologous to the laminin receptor precursor

(2010) L. Fernandez-Calvino et al.   JOURNAL OF GENERAL VIROLOGY

Helper component-proteinase (HC-Pro) protein ofPapaya ringspot virusinteracts with papaya calreticulin

(2010) WENTAO SHEN et al.   MOLECULAR PLANT PATHOLOGY

The 20S proteasome α5 subunit of Arabidopsis thaliana carries an RNase activity and interacts in planta with the Lettuce mosaic potyvirus HcPro protein

(2010) ANNE-SOPHIE DIELEN et al.   MOLECULAR PLANT PATHOLOGY

Form, Function, and Regulation of ARGONAUTE Proteins

(2010) Allison Mallory et al.   PLANT CELL

Arabidopsis RNA-Dependent RNA Polymerases and Dicer-Like Proteins in Antiviral Defense and Small Interfering RNA Biogenesis during Turnip Mosaic Virus Infection

(2010) H. Garcia-Ruiz et al.   PLANT CELL

Small Silencing RNAs in Plants Are Mobile and Direct Epigenetic Modification in Recipient Cells

(2010) A. Molnar et al.   SCIENCE

Mapping the self-interacting domains of TuMV HC-Pro and the subcellular localization of the protein

(2010) Hongying Zheng et al.   VIRUS GENES

Two Plant Viral Suppressors of Silencing Require the Ethylene-Inducible Host Transcription Factor RAV2 to Block RNA Silencing

(2010) Matthew W. Endres et al.   PLoS Pathogens

Viral Protein Inhibits RISC Activity by Argonaute Binding through Conserved WG/GW Motifs

(2010) Ana Giner et al.   PLoS Pathogens

Cassava Brown Streak Virus (Potyviridae) Encodes a Putative Maf/HAM1 Pyrophosphatase Implicated in Reduction of Mutations and a P1 Proteinase That Suppresses RNA Silencing but Contains No HC-Pro

(2009) D. R. Mbanzibwa et al.   JOURNAL OF VIROLOGY

Compensatory Molecular Evolution of HC-Pro, an RNA-Silencing Suppressor from a Plant RNA Virus

(2009) C. Torres-Barcelo et al.   MOLECULAR BIOLOGY AND EVOLUTION

Mutational analysis of interaction between coat protein and helper component-proteinase ofSoybean mosaic virusinvolved in aphid transmission

(2009) JANG-KYUN SEO et al.   MOLECULAR PLANT PATHOLOGY

Activation of the Salicylic Acid Signaling Pathway EnhancesClover yellow vein virusVirulence in Susceptible Pea Cultivars

(2009) Go Atsumi et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Discriminating Mutations of HC-Pro ofZucchini yellow mosaic viruswith Differential Effects on Small RNA Pathways Involved in Viral Pathogenicity and Symptom Development

(2009) Hui-Wen Wu et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Control of Nuclear and Nucleolar Localization of Nuclear Inclusion Protein a of Picorna-Like Potato virus A in Nicotiana Species

(2009) M.-L. Rajamaki et al.   PLANT CELL

N-terminal of Papaya ringspot virus type-W (PRSV-W) helper component proteinase (HC-Pro) is essential for PRSV systemic infection in zucchini

(2009) Yun-Kiam Yap et al.   VIRUS GENES

Protein–protein interactions in two potyviruses using the yeast two-hybrid system

(2009) Lin Lin et al.   VIRUS RESEARCH

From Hypo- to Hypersuppression: Effect of Amino Acid Substitutions on the RNA-Silencing Suppressor Activity of the Tobacco etch potyvirus HC-Pro

(2008) C. Torres-Barcelo et al.   GENETICS

Cylindrical inclusion protein of potato virus A is associated with a subpopulation of particles isolated from infected plants

(2008) R. Gabrenaite-Verkhovskaya et al.   JOURNAL OF GENERAL VIROLOGY

HC-Pro protein of sugar cane mosaic virus interacts specifically with maize ferredoxin-5 in vitro and in planta

(2008) Y.-Q. Cheng et al.   JOURNAL OF GENERAL VIROLOGY

The acquisition of molecular determinants involved in potato virus Y necrosis capacity leads to fitness reduction in tobacco plants

(2008) M. Rolland et al.   JOURNAL OF GENERAL VIROLOGY

Structure of Flexible Filamentous Plant Viruses

(2008) A. Kendall et al.   JOURNAL OF VIROLOGY

Gain of Virulence onRsv1-Genotype Soybean by an AvirulentSoybean mosaic virusRequires Concurrent Mutations in Both P3 and HC-Pro

(2008) A. L. Eggenberger et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Adaptation ofSoybean mosaic virusAvirulent Chimeras Containing P3 Sequences from Virulent Strains toRsv1-Genotype Soybeans Is Mediated by Mutations in HC-Pro

(2008) M. R. Hajimorad et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Contrasting effects of HC-Pro and 2b viral suppressors from Sugarcane mosaic virus and Tomato aspermy cucumovirus on the accumulation of siRNAs

(2008) Xiaoming Zhang et al.   VIROLOGY

Presence of P1b and absence of HC-Pro in Squash vein yellowing virus suggests a general feature of the genus Ipomovirus in the family Potyviridae

(2008) Weimin Li et al.   VIRUS RESEARCH

A member of a new genus in the Potyviridae infects Rubus

(2008) James Susaimuthu et al.   VIRUS RESEARCH