Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

The role of microglia activation in the development of sepsis-induced long-term cognitive impairment

(2015) Monique Michels et al.   BRAIN BEHAVIOR AND IMMUNITY

The blood-brain barrier in neuroimmunology: Tales of separation and assimilation

(2015) W.A. Banks   BRAIN BEHAVIOR AND IMMUNITY

Hypothermic Total Liquid Ventilation Is Highly Protective Through Cerebral Hemodynamic Preservation and Sepsis-Like Mitigation After Asphyxial Cardiac Arrest*

(2015) Matthias Kohlhauer et al.   CRITICAL CARE MEDICINE

A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans

(2015) Reynold Spector et al.   EXPERIMENTAL NEUROLOGY

Fibronectin changes in eosinophilic meningitis with blood–CSF barrier disruption

(2015) Ling-Yuh Shyu et al.   EXPERIMENTAL PARASITOLOGY

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Lipid A-activated inducible nitric oxide synthase expression via nuclear factor-κB in mouse choroid plexus cells

(2015) Masaoki Takano et al.   IMMUNOLOGY LETTERS

Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy

(2015) Rong Gao et al.   INFLAMMATION

Neurodevelopmental and Behavioral Outcomes in Children With Sepsis-Associated Encephalopathy Admitted to Pediatric Intensive Care Unit

(2015) Jasmine Kaur et al.   JOURNAL OF CHILD NEUROLOGY

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

(2015) William A. Banks et al.   Journal of Neuroinflammation

Systemic inflammation and microglial activation: systematic review of animal experiments

(2015) Inge C.M. Hoogland et al.   Journal of Neuroinflammation

Simvastatin attenuates sepsis-induced blood-brain barrier integrity loss

(2015) Chen-Hsien Yang et al.   JOURNAL OF SURGICAL RESEARCH

Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory ActivityIn VitroandIn Vivo

(2015) J. Aerts et al.   MEDIATORS OF INFLAMMATION

Unknown

(2015) Monique Michels et al.   MOLECULAR MEDICINE

Ethanol-Induced TLR4/NLRP3 Neuroinflammatory Response in Microglial Cells Promotes Leukocyte Infiltration Across the BBB

(2015) Silvia Alfonso-Loeches et al.   NEUROCHEMICAL RESEARCH

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

The choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system

(2015) Fernanda Marques et al.   Frontiers in Cellular Neuroscience

Systemic Inflammation and the Brain: Novel Roles of Genetic, Molecular, and Environmental Cues as Drivers of Neurodegeneration

(2015) Roman Sankowski et al.   Frontiers in Cellular Neuroscience

Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis

(2015) Jing-Jing Zhou et al.   Neuroscience Bulletin

Development of the choroid plexus and blood-CSF barrier

(2015) Shane A. Liddelow   Frontiers in Neuroscience

Serum MMP-8 and TIMP-1 in Critically Ill Patients with Acute Respiratory Failure

(2014) Johanna Hästbacka et al.   ANESTHESIA AND ANALGESIA

Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis

(2014) Lingling Liu et al.   BRAIN RESEARCH

Sepsis in the Central Nervous System and Antioxidant Strategies with Nacetylcysteine, Vitamins and Statins

(2014) Amanda Steckert et al.   CURRENT NEUROVASCULAR RESEARCH

Sepsis-Associated Encephalopathy: Review of the Neuropsychiatric Manifestations and Cognitive Outcome

(2014) Cory D. Lamar et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Activated Microglia-Induced Deficits in Excitatory Synapses Through IL-1β: Implications for Cognitive Impairment in Sepsis

(2014) Carolina A. Moraes et al.   MOLECULAR NEUROBIOLOGY

Phosphoinositide 3-Kinase γ Affects LPS-Induced Disturbance of Blood–Brain Barrier Via Lipid Kinase-Independent Control of cAMP in Microglial Cells

(2014) Adrian Frister et al.   NEUROMOLECULAR MEDICINE

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Molecular and Cellular Regulation of Toll-Like Receptor-4 Activity Induced by Lipopolysaccharide Ligands

(2014) Ardiyanto Liaunardy-Jopeace et al.   Frontiers in Immunology

Sepsis-induced changes in behavioral stereotypy in rats; involvement of tumor necrosis factor-alpha, oxidative stress, and dopamine turnover

(2013) Oytun Erbaş et al.   JOURNAL OF SURGICAL RESEARCH

Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis

(2013) Felipe Dal-Pizzol et al.   MOLECULAR NEUROBIOLOGY

Il1-β Involvement in Cognitive Impairment after Sepsis

(2013) Francielle Mina et al.   MOLECULAR NEUROBIOLOGY

Acute Brain Inflammation and Oxidative Damage Are Related to Long-Term Cognitive Deficits and Markers of Neurodegeneration in Sepsis-Survivor Rats

(2013) Mágada T. Schwalm et al.   MOLECULAR NEUROBIOLOGY

Correlation of Acute Phase Inflammatory and Oxidative Markers With Long-term Cognitive Impairment in Sepsis Survivors Rats

(2013) Daiane Biff et al.   SHOCK

Regulation of Toll-Like Receptors in the Choroid Plexus in the Immature Brain After Systemic Inflammatory Stimuli

(2013) Linnea Stridh et al.   Translational Stroke Research

Understanding brain dysfunction in sepsis

(2013) Romain Sonneville et al.   Annals of Intensive Care

Protective effects of isothiocyanates on blood-CSF barrier disruption induced by oxidative stress

(2012) Jianming Xiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Protective effects of guanosine against sepsis-induced damage in rat brain and cognitive impairment

(2012) Fabricia Petronilho et al.   BRAIN BEHAVIOR AND IMMUNITY

At the extreme end of the psychoneuroimmunological spectrum: Delirium as a maladaptive sickness behaviour response

(2012) Colm Cunningham et al.   BRAIN BEHAVIOR AND IMMUNITY

Phenotyping primary human microglia: Tight regulation of LPS responsiveness

(2012) Jeroen Melief et al.   GLIA

Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood-CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases

(2012) R. E. Vandenbroucke et al.   JOURNAL OF NEUROSCIENCE

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(2012) Sangeeta Chavan et al.   MOLECULAR MEDICINE

Neurodegenerative Evidence in Mice Brains with Cecal Ligation and Puncture-Induced Sepsis: Preventive Effect of the Free Radical Scavenger Edaravone

(2012) Hiroki Yokoo et al.   PLoS One

Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus

(2012) Sandro D. Mesquita et al.   Frontiers in Cellular Neuroscience

Cell trafficking through the choroid plexus

(2012) Rick B. Meeker et al.   Cell Adhesion & Migration

Sepsis-induced alterations in sleep of rats

(2011) Francesca Baracchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Tight Junctions in Brain Barriers During Central Nervous System Inflammation

(2011) Caroline Coisne et al.   ANTIOXIDANTS & REDOX SIGNALING

Traffic of leukocytes and cytokine up-regulation in the central nervous system in sepsis

(2011) Clarissa M. Comim et al.   INTENSIVE CARE MEDICINE

Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways

(2011) Rachid Kacimi et al.   Journal of Inflammation-London

Sepsis-associated encephalopathy and its differential diagnosis

(2010) Emanuele Iacobone et al.   CRITICAL CARE MEDICINE

Oxidative stress and endothelial dysfunction during sepsis

(2010) Olivier Huet   Frontiers in Bioscience-Landmark

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Increase of tumor necrosis factor-α in the blood induces the early activation of matrix metalloproteinase-9 in the brain

(2010) Mitsuru Tsuge et al.   MICROBIOLOGY AND IMMUNOLOGY

Alterations in Inflammatory Mediators, Oxidative Stress Parameters and Energetic Metabolism in the Brain of Sepsis Survivor Rats

(2010) Clarissa M. Comim et al.   NEUROCHEMICAL RESEARCH

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Mechanisms of Brain Signaling During Sepsis

(2009) Najla Akrout et al.   Current Neuropharmacology

Oxidative Mechanisms of Brain Dysfunction During Sepsis

(2009) Felipe Dal-Pizzol et al.   NEUROCHEMICAL RESEARCH

Septic Encephalopathy: Relationship to Serum and Cerebrospinal Fluid Levels of Adhesion Molecules, Lipid Peroxides and S-100B Protein

(2009) S. A. Hamed et al.   NEUROPEDIATRICS

Depressive-Like Parameters in Sepsis Survivor Rats

(2009) Clarissa M. Comim et al.   NEUROTOXICITY RESEARCH

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

(2009) Britta Engelhardt et al.   Seminars in Immunopathology

Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia

(2008) Moon-Sook Woo et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial respiratory chain and creatine kinase activities in rat brain after sepsis induced by cecal ligation and perforation

(2008) Clarissa M. Comim et al.   MITOCHONDRION

Role of Toll-like receptor responses for sepsis pathogenesis

(2007) Heike Weighardt et al.   IMMUNOBIOLOGY

Injury of the Blood Brain Barrier and Up-Regulation of ICAM-1 in Polymicrobial Sepsis

(2007) Stefan Hofer et al.   JOURNAL OF SURGICAL RESEARCH