Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) Activation Balance Astrocyte Polarization into a Proinflammatory Phenotype

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Astroglial heterogeneity: merely a neurobiological question? Or an opportunity for neuroprotection and regeneration after brain injury?

(2016) AlbertoJavier Ramos   Neural Regeneration Research

Isolation and Characterization of Ischemia-Derived Astrocytes (IDAs) with Ability to Transactivate Quiescent Astrocytes

(2016) Alejandro Villarreal et al.   Frontiers in Cellular Neuroscience

The Effect of miR-132, miR-146a, and miR-155 on MRP8/TLR4-Induced Astrocyte-Related Inflammation

(2015) Huimin Kong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Chronic systemic IL-1β exacerbates central neuroinflammation independently of the blood–brain barrier integrity

(2015) Verónica Murta et al.   JOURNAL OF NEUROIMMUNOLOGY

Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain

(2015) Yousuke Nakano et al.   JOURNAL OF NEUROIMMUNOLOGY

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2015) Jia Y Lee et al.   Journal of Neuroinflammation

Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes

(2015) Carla Marinelli et al.   Journal of Neuroinflammation

HIV-1 increases TLR responses in human primary astrocytes

(2015) M Jesús Serramía et al.   Scientific Reports

S100B protein activates a RAGE-dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis

(2014) Alejandro Villarreal et al.   JOURNAL OF NEUROCHEMISTRY

The immune response after hypoxia-ischemia in a mouse model of preterm brain injury

(2014) Anna-Maj Albertsson et al.   Journal of Neuroinflammation

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

The Proinflammatory RAGE/NF-κB Pathway Is Involved in Neuronal Damage and Reactive Gliosis in a Model of Sleep Apnea by Intermittent Hypoxia

(2014) Maria Florencia Angelo et al.   PLoS One

Toll-Like Receptors 2, -3 and -4 Prime Microglia but not Astrocytes Across Central Nervous System Regions for ATP-Dependent Interleukin-1β Release

(2014) Laura Facci et al.   Scientific Reports

Astrocyte-Microglia Cooperation in the Expression of a Pro-Inflammatory Phenotype

(2013) Massimo Barbierato et al.   CNS & Neurological Disorders-Drug Targets

Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases

(2013) Christopher J Pelham et al.   Expert Review of Clinical Immunology

Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-β1

(2013) Kana Sugimoto et al.   GLIA

Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

(2013) Patrick Wunderlich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination

(2013) H.C. Hoyos et al.   NEUROBIOLOGY OF DISEASE

Targeting Toll-Like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases

(2013) Athina Savva et al.   Frontiers in Immunology

Kallikrein 6 is a novel molecular trigger of reactive astrogliosis

(2012) Isobel A. Scarisbrick et al.   BIOLOGICAL CHEMISTRY

Microglia are required for astroglial toll-like receptor 4 response and for optimal TLR2 and TLR3 response

(2012) Thomas H. Holm et al.   GLIA

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke

(2011) Ursula Heldmann et al.   EXPERIMENTAL NEUROLOGY

S100B alters neuronal survival and dendrite extension via RAGE-mediated NF-κB signaling

(2011) Alejandro Villarreal et al.   JOURNAL OF NEUROCHEMISTRY

Immunolocalization of Toll-Like Receptors 2 and 4 as well as Their Endogenous Ligand, Heat Shock Protein 70, in Rat Traumatic Brain Injury

(2011) Zhiren Zhang et al.   NEUROIMMUNOMODULATION

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

(2010) S. Alfonso-Loeches et al.   JOURNAL OF NEUROSCIENCE

High-Mobility Group Box 1 Promotes Metalloproteinase-9 Upregulation Through Toll-Like Receptor 4 After Cerebral Ischemia

(2010) Jianhua Qiu et al.   STROKE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea

(2009) Rolando Xavier Aviles-Reyes et al.   JOURNAL OF NEUROCHEMISTRY

Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)

(2008) Judy R. van Beijnum et al.   ANGIOGENESIS

The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage

(2008) S. Muhammad et al.   JOURNAL OF NEUROSCIENCE