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Immunology
Xiao-Long Zhang, Jian An, Yong-Zhi Deng, Xuan-Zheng Fang, Cai-Yun Xu, Xu-Fang Liu, Ze-Hong Bai, Gang Zhang, Ming-Yuan Cui
Summary: Severe acute lung injury (ALI) is a major cause of morbidity and mortality worldwide. MicroRNAs (miRNAs) have been identified as potential biomarkers and therapeutic targets for ALI. This study reveals a significant role for the miR-762/NFIX pathway in the pathogenesis of ALI, suggesting that targeting this pathway could be beneficial for the diagnosis, prevention, and treatment of ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Zu -An Shi, Cheng-Xiu Yu, Zhi-Chao Wu, Chang -Lin Chen, Fa -Ping Tu, Yong Wan
Summary: The study investigated the protective effect of Fingolimod in a rat model of acute lung injury induced by LPS, showing inhibition of NF-kappa B activation, reduction of inflammatory cytokines, and improvement in lung tissue injury. These results suggest a promising therapeutic potential for Fingolimod in LPS-induced ALI by regulating the inflammatory pathway and barrier dysfunction of alveolar capillaries.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
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Cell Biology
Shishuo Sun, Yizhou Yao, Chao Huang, Heng Xu, Yuxiao Zhao, Yifei Wang, Yizhang Zhu, Yangna Miao, Xinhui Feng, Xiaoge Gao, Junnian Zheng, Qing Zhang
Summary: Loss of CD36 attenuates LPS-induced ALI by reducing M1 polarization of macrophages.
CELLULAR IMMUNOLOGY
(2022)
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Cell Biology
Xiaoling Li, Riming Huang, Kaifeng Liu, Mingyue Li, Hui Luo, Liao Cui, Lei Huang, Lianxiang Luo
Summary: Fucoxanthin alleviates lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and the TLR4/MyD88 signaling axis, indicating a potential therapeutic strategy for controlling ALI.
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Plant Sciences
Tian-qi Xuan, Guohua Gong, Huanhuan Du, Chunyan Liu, Yun Wu, Guilan Bao, Qianqian Ma, Dong Zhen
Summary: This study aimed to investigate the potential of pteryxin in alleviating LPS-induced lung injury and explore the underlying mechanism. The results indicated that pteryxin effectively reduced the severity of lung injury by suppressing the MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
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Plant Sciences
Weiwei Zhu, Wu Luo, Jibo Han, Qiuyan Zhang, Lijun Ji, Aleksandr V. Samorodov, Valentin N. Pavlov, Zaishou Zhuang, Daona Yang, Lina Yin, Lijiang Huang, Guang Liang, Joo Young Huh, Yi Wang
Summary: This study investigated the anti-inflammatory mechanism of Schisandrin B (Sch B) in macrophages and an animal model of acute lung injury (ALI) and found that Sch B directly binds to MyD88 to regulate inflammatory responses and inhibit the expression of inflammatory factors. The study suggests that Sch B has therapeutic potential for ALI and other MyD88-dependent inflammatory diseases.
Article
Biochemistry & Molecular Biology
Qhaweni Dhlamini, Wei Wang, Guifeng Feng, Aiping Chen, Lei Chong, Xue Li, Quan Li, Jin Wu, Depu Zhou, Jie Wang, Hailin Zhang, Jin-San Zhang
Summary: This study demonstrates the protective effects of FGF1 pretreatment against acute lung injury (ALI) and its potential mechanisms involving anti-inflammatory and antioxidant effects.
MOLECULAR MEDICINE
(2022)
Article
Plant Sciences
Won Young Jang, Hwa Pyoung Lee, Seung A. Kim, Lei Huang, Ji Hye Yoon, Chae Yun Shin, Ankita Mitra, Han Gyung Kim, Jae Youl Cho
Summary: This study evaluated the anti-inflammatory effects of Angiopteris cochinchinensis de Vriese extract (Ac-EE) on acute lung injury (ALI) and demonstrated its potential as an effective botanical drug. Ac-EE reduced nitric oxide production and inhibited the production of proinflammatory mediators and cytokines. It also showed protective effects on lung tissue by reducing edema and lung injury.
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Cell Biology
Jia Zhou, Zhengliang Peng, Jian Wang
Summary: The study showed that the DPP-4 inhibitor Trelagliptin has protective effects against LPS-induced ALI by reducing inflammation and oxidative stress, thereby improving the pathological condition of lung injury.
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Immunology
Pengcheng Cui, Chao Chen, Yan Cui, Xia Qiu, Kaiye Yue, Tengfang Li, Hedong Zhang, Wenjia Yuan, Yixin Xie, Yong Guo, Zhouqi Tang, Yaguang Li, Fenghua Peng, Xin Jiang, Xuewei Luo, Longkai Peng, Zhongquan Qi, Helong Dai
Summary: DsbA-L protein promotes AKI by upregulating voltage-dependent anion-selective channels in proximal tubular cells. However, its role in immune cells remains unclear. This study found that DsbA-L deletion attenuates LPS-induced AKI and affects arginine metabolism and inflammatory cytokines, potentially through the NF-κB/AP-1 pathway.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Cell Biology
Jing Yue, Kai Su, Guangxin Zhang, Jinghui Yang, Chengbi Xu, Xueshibojie Liu
Summary: Dihydrotanshinone (DIH) can regulate LPS-induced acute lung injury (ALI) in mice by inhibiting the NF-κB signaling pathway.
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Veterinary Sciences
Qiu Zhong, Yaogui Sun, Yinlan Xu, Ajab Khan, Jianhua Guo, Zhirui Wang, Na Sun, Hongquan Li
Summary: Research demonstrates that Physalin can effectively treat LPS-induced acute lung injury by regulating a series of cellular pathways and protein expression, reducing inflammation and apoptosis in alveolar epithelial cells both in vivo and in vitro.
PAKISTAN VETERINARY JOURNAL
(2021)
Article
Cell Biology
Li Du, Jinrong Zhang, Xiyue Zhang, Chunyan Li, Qi Wang, Guangping Meng, Xingchi Kan, Jie Zhang, Yuxi Jia
Summary: In this study, it was found that oxypeucedanin could alleviate LPS-induced ALI by inhibiting the activation of inflammatory pathways and maintaining the integrity of the lung air-blood barrier.
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Medicine, Research & Experimental
Qi-ying Shen, Dong Wang, Han-yang Xu, Chuan-sheng Wei, Xue-ying Xiao, Jun Liu, Yu-jun Shen, Lei Fang, Li-jie Feng, Yu-xian Shen
Summary: This study found that mesencephalic astrocyte-derived neurotrophic factor (MANF) plays a suppressive role in acute lung injury (ALI). It is increased during inflammatory conditions and can decrease LPS-induced lung injury. Additionally, MANF inhibits macrophage polarization and NF-kappa B signal pathway activation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Physiology
Jiajia Jin, Hong Qian, Bing Wan, Li Zhou, Cen Chen, Yanling Lv, Meizi Chen, Suhua Zhu, Liang Ye, Xiaoxia Wang, Wujian Xu, Tangfeng Lv, Yong Song
Summary: Decreased expression of GGPPS in macrophages aggravates lung injury and inflammation in ARDS, at least partly by regulating Rac1-dependent NF-kappa B signaling. GGPPS in macrophages may represent a novel therapeutic target in ARDS.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
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Medicine, General & Internal
Jun Yin, Chun-Xue Bai
CHINESE MEDICAL JOURNAL
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Computer Science, Interdisciplinary Applications
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COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2018)
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Food Science & Technology
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FOOD AND CHEMICAL TOXICOLOGY
(2018)
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Critical Care Medicine
Bao Q. Wang, Meng Shi, Jian P. Zhang, Xie Wu, Mei J. Chang, Zhi H. Chen, Hua H. Shen, Yuan L. Song, Jian Zhou, Chun X. Bai
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Cell Biology
Linlin Wang, Meng Shi, Lin Tong, Jian Wang, Shimeng Ji, Jing Bi, Cuicui Chen, Jinjun Jiang, Chunxue Bai, Jian Zhou, Yuanlin Song
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Oncology
Linlin Wang, Jing Liu, Jinguo Liu, Xiaoyan Chen, Meijia Chang, Jing Li, Jian Zhou, Chunxue Bai, Yuanlin Song
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
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Immunology
Xiaocen Wang, Xiaojing An, Xun Wang, Xianglin Hu, Jing Bi, Ling Tong, Dong Yang, Yuanlin Song, Chunxue Bai
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
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Oncology
Jian Zhou, Guimei Qu, Ge Zhang, Zuoren Wu, Jing Liu, Dawei Yang, Jing Li, Meijia Chang, Hengshan Zeng, Jie Hu, Tao Fang, Yuanlin Song, Chunxue Bai
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
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Oncology
Peng Song, Xiaoxia Cui, Li Bai, Xiangdong Zhou, Xiaoli Zhu, Jian Zhang, Faguang Jin, Jianping Zhao, Chengzhi Zhou, Yanbin Zhou, Xiaoju Zhang, Kai Wang, Qi Wang, Yao Yu, Xiaoyu Zhang, Chunxue Bai, Li Zhang
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Critical Care Medicine
Yuanlin Song, Chen Yao, Yongming Yao, Hui Han, Xiaodong Zhao, Kaijiang Yu, Luyi Liu, Ying Xu, Zhongmin Liu, Qingshan Zhou, Ying Wang, Zhuang Ma, Youguang Zheng, Dawei Wu, Zhongzhi Tang, Minzhou Zhang, Shuming Pan, Yanfen Chai, Yan Song, Jian Zhang, Lei Pan, Yi Liu, He Yu, Xuezhong Yu, Hong Zhang, Xiaoge Wang, Zhaohui Du, Xianyao Wan, Yijun Tang, Yingping Tian, Yimin Zhu, Hongliang Wang, Xiaoyan Yan, Zhi Liu, Boli Zhang, Nanshan Zhong, Hongcai Shang, Chunxue Bai
CRITICAL CARE MEDICINE
(2019)
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Medicine, General & Internal
Kewu Huang, Ting Yang, Jianying Xu, Lan Yang, Jianping Zhao, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Yahong Chen, Tieying Sun, Guangliang Shan, Yingxiang Lin, Guodong Xu, Sinan Wu, Chaolong Wang, Ruiying Wang, Zhihong Shi, Yongjian Xu, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Wen Li, Liren Ding, Chun Wan, Wanzhen Yao, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Biao Zhang, Dan Xiao, Zuomin Wang, Zhengming Chen, Xiaoning Bu, Hong Zhang, Xiaolei Zhang, Li An, Shu Zhang, Jianguo Zhu, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Lirong Liang, Xunliang Tong, Huaping Dai, Bin Cao, Tangchun Wu, Kian Fan Chung, Jiang He, Chen Wang
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Allergy
Tari Haahtela, Leena von Hertzen, Josep M. Anto, Chunxue Bai, Abay Baigenzhin, Eric D. Bateman, Digambar Behera, Kazi Bennoor, Paulo Camargos, Niels Chavannes, Jaime Correia de Sousa, Alvaro Cruz, Maria Do Ceu Teixeira, Marina Erhola, Eeva Furman, Bilun Gemicioglu, Sandra Gonzalez Diaz, Peter W. Hellings, Pekka Jousilahti, Nikolai Khaltaev, Vitezslav Kolek, Piotr Kuna, Stefania La Grutta, Le Thi Tuyet Lan, Tamaz Maglakelidze, Mohamed R. Masjedi, Florin Mihaltan, Yousser Mohammad, Elizabete Nunes, Arvid Nyberg, Jorge Quel, Jose Rosado-Pinto, Hironori Sagara, Boleslaw Samolinski, Dean Schraufnagel, Talant Sooronbaev, Mohamed Tag Eldin, Teresa To, Arunas Valiulis, Cherian Varghese, Tuula Vasankari, Giovanni Viegi, Tonya Winders, Anahi Yanez, Arzu Yorgancioglu, Osman Yusuf, Jean Bousquet, Nils E. Billo
CLINICAL AND TRANSLATIONAL ALLERGY
(2019)
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Oncology
Dawei Yang, Yang Liu, Chunxue Baia, Xiandong Wang, Charles A. Powell
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Medicine, General & Internal
Chaomin Wu, Xiaoyan Chen, Yanping Cai, Jia'an Xia, Xing Zhou, Sha Xu, Hanping Huang, Li Zhang, Xia Zhou, Chunling Du, Yuye Zhang, Juan Song, Sijiao Wang, Yencheng Chao, Zeyong Yang, Jie Xu, Xin Zhou, Dechang Chen, Weining Xiong, Lei Xu, Feng Zhou, Jinjun Jiang, Chunxue Bai, Junhua Zheng, Yuanlin Song
JAMA INTERNAL MEDICINE
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Cardiac & Cardiovascular Systems
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