Highlights on mechanisms of drugs targeting MDSCs: providing a novel perspective on cancer treatment

A melanoma subtype with intrinsic resistance to BRAF inhibition identified by receptor tyrosine kinases gene-driven classification

(2015) Matteo Dugo et al.   Oncotarget

Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma

(2015) Raffaella Iannone et al.   NEOPLASIA

Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling

(2014) Thomas A. Mace et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

HMGB1 Enhances Immune Suppression by Facilitating the Differentiation and Suppressive Activity of Myeloid-Derived Suppressor Cells

(2014) K. H. Parker et al.   CANCER RESEARCH

BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity

(2014) Y. Cao et al.   CANCER RESEARCH

Reductions in Myeloid-Derived Suppressor Cells and Lung Metastases using AZD4547 Treatment of a Metastatic Murine Breast Tumor Model

(2014) Li Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A copper chelate selectively triggers apoptosis in myeloid-derived suppressor cells in a drug-resistant tumor model and enhances antitumor immune response

(2014) Paramita Chakraborty et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice

(2014) Young-Hee Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Origin and pharmacological modulation of tumor-associated regulatory dendritic cells

(2014) Hua Zhong et al.   INTERNATIONAL JOURNAL OF CANCER

Blockade of Fas Signaling in Breast Cancer Cells Suppresses Tumor Growth and Metastasis via Disruption of Fas Signaling-initiated Cancer-related Inflammation

(2014) Qiuyan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2014) J.-I. Youn et al.   JOURNAL OF IMMUNOLOGY

Shikonin Inhibits the Proliferation of Human Lens Epithelial Cells by Inducing Apoptosis through ROS and Caspase-Dependent Pathway

(2014) Wan-Rong Huang et al.   MOLECULES

Postnatal development and LPS responsiveness of pulmonary adenosine receptor expression and of adenosine-metabolizing enzymes in mice

(2014) Juhani Metsola et al.   PEDIATRIC RESEARCH

MDSCs Mediate Angiogenesis and Predispose Canine Mammary Tumor Cells for Metastasis via IL-28/IL-28RA (IFN-λ) Signaling

(2014) Joanna Mucha et al.   PLoS One

ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment

(2014) G Bianchi et al.   Cell Death & Disease

Tasquinimod Modulates Suppressive Myeloid Cells and Enhances Cancer Immunotherapies in Murine Models

(2014) L. Shen et al.   Cancer Immunology Research

Targeting Immune Suppression with PDE5 Inhibition in End-Stage Multiple Myeloma

(2014) K. A. Noonan et al.   Cancer Immunology Research

Anti-Bv8 Antibody and Metronomic Gemcitabine Improve Pancreatic Adenocarcinoma Treatment Outcome Following Weekly Gemcitabine Therapy

(2014) Erez Hasnis et al.   NEOPLASIA

Targeting the adenosine A2b receptor in the tumor microenvironment overcomes local immunosuppression by myeloid-derived suppressor cells

(2014) Silvana Morello et al.   OncoImmunology

Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells

(2014) Nicolas Espagnolle et al.   Cancers

Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer

(2013) P. Cheng et al.   CANCER RESEARCH

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+T-cell activation events

(2013) Elio Schouppe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vemurafenib reverses immunosuppression by myeloid derived suppressor cells

(2013) Bastian Schilling et al.   INTERNATIONAL JOURNAL OF CANCER

Deregulation of Apoptotic Factors Bcl-xL and Bax Confers Apoptotic Resistance to Myeloid-derived Suppressor Cells and Contributes to Their Persistence in Cancer

(2013) Xiaolin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway

(2013) Archana Thakur et al.   Journal of Translational Medicine

The kinship of neutrophils and granulocytic myeloid-derived suppressor cells in cancer: Cousins, siblings or twins?

(2013) Sven Brandau et al.   SEMINARS IN CANCER BIOLOGY

The adenosinergic system in cancer

(2013) Rosalinda Sorrentino et al.   OncoImmunology

G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells

(2012) Ariane Luyckx et al.   CLINICAL IMMUNOLOGY

Myeloid-derived suppressor cells in transplantation and cancer

(2012) Jordi C. Ochando et al.   IMMUNOLOGIC RESEARCH

Myeloid-derived Suppressor Cells Adhere to Physiologic STAT3- vs STAT5-dependent Hematopoietic Programming, Establishing Diverse Tumor-Mediated Mechanisms of Immunologic Escape

(2012) Peter A. Cohen et al.   IMMUNOLOGICAL INVESTIGATIONS

Blockade of Myd88 signaling induces antitumor effects by skewing the immunosuppressive function of myeloid-derived suppressor cells

(2012) Eun-Hye Hong et al.   INTERNATIONAL JOURNAL OF CANCER

Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway

(2012) Z. Cai et al.   JOURNAL OF IMMUNOLOGY

Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived Suppressor Cells through Modulation of Vascular Endothelial Growth Factor Release

(2012) P. Jayaraman et al.   JOURNAL OF IMMUNOLOGY

TIMP-2 Targets Tumor-associated Myeloid Suppressor Cells With Effects in Cancer Immune Dysfunction and Angiogenesis

(2012) Liliana Guedez et al.   JOURNAL OF IMMUNOTHERAPY

Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cellsin vitroin a TLR4-independent manner

(2012) Tillmann Michels et al.   Journal of Immunotoxicology

Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells

(2012) Yisheng Zheng et al.   MOLECULAR IMMUNOLOGY

Myeloid-derived suppressor cells express the death receptor Fas and apoptose in response to T cell-expressed FasL

(2011) P. Sinha et al.   BLOOD

Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells

(2011) N. Obermajer et al.   BLOOD

A Th1 cytokine–enriched microenvironment enhances tumor killing by activated T cells armed with bispecific antibodies and inhibits the development of myeloid-derived suppressor cells

(2011) Archana Thakur et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients

(2011) Paola Filipazzi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Curcumin Induces the Differentiation of Myeloid-Derived Suppressor Cells and Inhibits Their Interaction with Cancer Cells and Related Tumor Growth

(2011) S. P. Tu et al.   Cancer Prevention Research

CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2011) C. Zoglmeier et al.   CLINICAL CANCER RESEARCH

The restoration of myeloid-derived suppressor cells as functional antigen-presenting cells by NKT cell help and all-trans-retinoic acid treatment

(2011) Jung-Mi Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Both miR-17-5p and miR-20a Alleviate Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating STAT3 Expression

(2011) M. Zhang et al.   JOURNAL OF IMMUNOLOGY

Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

(2011) Je-In Youn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

S100A8/A9 Activate Key Genes and Pathways in Colon Tumor Progression

(2011) M. Ichikawa et al.   MOLECULAR CANCER RESEARCH

Rgs2 Mediates Pro-Angiogenic Function of Myeloid Derived Suppressor Cells in the Tumor Microenvironment via Upregulation of MCP-1

(2011) Kimberly C. Boelte et al.   PLoS One

Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

(2011) Jeremy D. Waight et al.   PLoS One

Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model

(2011) C. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

(2011) Benjamin Toh et al.   PLOS BIOLOGY

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

(2010) Joris D Veltman et al.   BMC CANCER

Parallel inhibition of cell growth and induction of cell migration and invasion in breast cancer cells by bone morphogenetic protein 4

(2010) Johanna M. Ketolainen et al.   BREAST CANCER RESEARCH AND TREATMENT

Curcumin Inhibits Carcinogen and Nicotine-Induced Mammalian Target of Rapamycin Pathway Activation in Head and Neck Squamous Cell Carcinoma

(2010) C. A. Clark et al.   Cancer Prevention Research

Ligand-Independent Toll-like Receptor Signals Generated by Ectopic Overexpression of MyD88 Generate Local and Systemic Antitumor Immunity

(2010) Z. C. Hartman et al.   CANCER RESEARCH

Dietary Curcumin Attenuates Glioma Growth in a Syngeneic Mouse Model by Inhibition of the JAK1,2/STAT3 Signaling Pathway

(2010) J. Weissenberger et al.   CLINICAL CANCER RESEARCH

Myeloid-derived suppressor cell heterogeneity and subset definition

(2010) Elisa Peranzoni et al.   CURRENT OPINION IN IMMUNOLOGY

The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity

(2010) Je-In Youn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

(2010) Ilaria Marigo et al.   IMMUNITY

Myeloid derived suppressor cells and their role in tolerance induction in cancer

(2010) Taku Fujimura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Curcumin Selectively Induces Apoptosis in Cutaneous T-Cell Lymphoma Cell Lines and Patients’ PBMCs: Potential Role for STAT-3 and NF-κB Signaling

(2010) Chunlei Zhang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Subsets, expansion and activation of myeloid-derived suppressor cells

(2010) Eliana Ribechini et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

CD95 promotes tumour growth

(2010) Lina Chen et al.   NATURE

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies

(2009) J. Ozao-Choy et al.   CANCER RESEARCH

Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

(2009) Paulo C. Rodriguez et al.   CANCER RESEARCH

Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells

(2009) H. Xin et al.   CANCER RESEARCH

Transforming growth factor beta (TGF-β) and inflammation in cancer

(2009) Brian Bierie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Myeloid-derived suppressor cells in inflammation: Uncovering cell subsets with enhanced immunosuppressive functions

(2009) Vincenzo Bronte   EUROPEAN JOURNAL OF IMMUNOLOGY

Fas Signal Promotes Lung Cancer Growth by Recruiting Myeloid-Derived Suppressor Cells via Cancer Cell-Derived PGE2

(2009) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

IL4Rα + Myeloid-Derived Suppressor Cell Expansion in Cancer Patients

(2009) Susanna Mandruzzato et al.   JOURNAL OF IMMUNOLOGY

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

(2008) Li Yang et al.   CANCER CELL

Lung cancer patients’ CD4+ T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells

(2008) Minu K. Srivastava et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy

(2008) C. Marcela Diaz-Montero et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Myeloid-derived suppressor cell role in tumor-related inflammation

(2008) Luigi Dolcetti et al.   CANCER LETTERS

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice

(2008) Maciej Kujawski et al.   JOURNAL OF CLINICAL INVESTIGATION