Abortifacient metapristone (RU486 derivative) interrupts CXCL12/CXCR4 axis for ovarian metastatic chemoprevention

A Systematic Review of Symptoms for the Diagnosis of Ovarian Cancer

(2016) Mark H. Ebell et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

In vitro and in vivo efficacy and safety evaluation of metapristone and mifepristone as cancer metastatic chemopreventive agents

(2016) Jichuang Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Progesterone modulates endothelial progenitor cell (EPC) viability through the CXCL12/CXCR4/PI3K/Akt signalling pathway

(2016) Peng Yu et al.   CELL PROLIFERATION

CXCL12 promotes glycolytic reprogramming in acute myeloid leukemia cells via the CXCR4/mTOR axis

(2016) M Braun et al.   LEUKEMIA

Thirty-day rat toxicity study reveals reversible liver toxicity of mifepristone (RU486) and metapristone

(2016) Yingying Xiao et al.   TOXICOLOGY MECHANISMS AND METHODS

The paradigm-shifting idea and its practice: from traditional abortion Chinese medicine Murraya paniculata to safe and effective cancer metastatic chemopreventives

(2016) Zhou Jiang et al.   Oncotarget

Pharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention

(2016) Suhong Yu et al.   Scientific Reports

Thirty-day rat toxicity study reveals reversible liver toxicity of mifepristone (RU486) and metapristone

(2016) Yingying Xiao et al.   TOXICOLOGY MECHANISMS AND METHODS

Isolation and characterization of living circulating tumor cells in patients by immunomagnetic negative enrichment coupled with flow cytometry

(2015) Yusheng Lu et al.   CANCER

CXCL12-CXCR4 Axis Promotes Proliferation, Migration, Invasion, and Metastasis of Ovarian Cancer

(2015) Qing Guo et al.   ONCOLOGY RESEARCH

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition

(2015) E. Kiermaier et al.   SCIENCE

Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: Comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex

(2015) Suhong Yu et al.   Scientific Reports

Synthesis, Spectral Characterization, and In Vitro Cellular Activities of Metapristone, a Potential Cancer Metastatic Chemopreventive Agent Derived from Mifepristone (RU486)

(2014) Jichuang Wang et al.   AAPS Journal

Chemokine signaling in development and disease

(2014) J. Wang et al.   DEVELOPMENT

CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival

(2014) María José Moreno et al.   JOURNAL OF PATHOLOGY

A novel UPLC/MS/MS method for rapid determination of metapristone in rat plasma, a new cancer metastasis chemopreventive agent derived from mifepristone (RU486)

(2014) Jian-Zhong Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The Unique Pharmacological Characteristics of Mifepristone (RU486): From Terminating Pregnancy to Preventing Cancer Metastasis

(2014) Jianzhong Chen et al.   MEDICINAL RESEARCH REVIEWS

CXCR4-Targeted Therapy Inhibits VEGF Expression and Chondrosarcoma Angiogenesis and Metastasis

(2013) X. Sun et al.   MOLECULAR CANCER THERAPEUTICS

SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial–mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway

(2012) Xuqi Li et al.   CANCER LETTERS

New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation

(2012) F. Jin et al.   MOLECULAR CANCER RESEARCH

Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines

(2012) Ashley A. Powell et al.   PLoS One

Human cytomegalovirus infection inhibits CXCL12- mediated migration and invasion of human extravillous cytotrophoblasts

(2012) Jessica A Warner et al.   Virology Journal

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs

(2011) Robert R. Langley et al.   INTERNATIONAL JOURNAL OF CANCER

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

(2010) Margaret L. Gardel et al.   Annual Review of Cell and Developmental Biology

Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion

(2010) Nami Miyanishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

The relationship between early embryo development and tumourigenesis

(2010) Yanlei Ma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Hepatic Stellate Cells Promote Liver Metastasis of Colon Cancer Cells by the Action of SDF-1/CXCR4 Axis

(2009) Ryo Matsusue et al.   ANNALS OF SURGICAL ONCOLOGY

Mechanics of the F-actin cytoskeleton

(2009) Jonathan Stricker et al.   JOURNAL OF BIOMECHANICS

Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls

(2008)   LANCET