Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death

Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling

(2016) Rodolfo Ciuffa et al.   JOURNAL OF PROTEOME RESEARCH

A Triple Knockout (TKO) Proteomics Standard for Diagnosing Ion Interference in Isobaric Labeling Experiments

(2016) Joao A. Paulo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics

(2015) E-W Lee et al.   CELL DEATH AND DIFFERENTIATION

Putting chromatin in its place: the pioneer factor NeuroD1 modulates chromatin state to drive cell fate decisions

(2015) A. Glahs et al.   EMBO JOURNAL

Global Analysis of Protein Expression and Phosphorylation Levels in Nicotine-Treated Pancreatic Stellate Cells

(2015) Joao A. Paulo et al.   JOURNAL OF PROTEOME RESEARCH

Better Safe than Sorry: Interlinked Feedback Loops for Robust Mitophagy

(2015) Andrew G. Manford et al.   MOLECULAR CELL

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

(2015) Alban Ordureau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of systemic proteostasis by the nervous system

(2015) Pablo Mardones et al.   TRENDS IN CELL BIOLOGY

Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate

(2015) Ramesh K. Krishnan et al.   Nature Communications

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

MS-Viewer: A Web-based Spectral Viewer for Proteomics Results

(2014) Peter R. Baker et al.   MOLECULAR & CELLULAR PROTEOMICS

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF- B Activation, and Is Active in Patient-Derived Xenograft Models

(2014) C. A. Benetatos et al.   MOLECULAR CANCER THERAPEUTICS

The Two Faces of Receptor Interacting Protein Kinase-1

(2014) Ricardo Weinlich et al.   MOLECULAR CELL

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Regulating the Ribosome: A Spotlight on RNA Dark Matter

(2014) Nathanael G. Lintner et al.   MOLECULAR CELL

Linear ubiquitin chains: NF-κB signalling, cell death and beyond

(2014) Kazuhiro Iwai et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A comprehensive proteomic and phosphoproteomic analysis of yeast deletion mutants of 14-3-3 orthologs and associated effects of rapamycin

(2014) Joao A. Paulo et al.   PROTEOMICS

Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics

(2014) Joao A. Paulo et al.   PROTEOMICS

Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis

(2013) Thomas McQuade et al.   BIOCHEMICAL JOURNAL

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

(2013) C. H. Emmerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increasing the Multiplexing Capacity of TMTs Using Reporter Ion Isotopologues with Isobaric Masses

(2012) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

The roles of ATF2 (activating transcription factor 2) in tumorigenesis

(2012) Malgorzata Gozdecka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

GSK3-SCFFBXW7 targets JunB for degradation in G2 to preserve chromatid cohesion before anaphase

(2012) B Pérez-Benavente et al.   ONCOGENE

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2

(2011) M Darding et al.   CELL DEATH AND DIFFERENTIATION

TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer

(2011) Henning Walczak   IMMUNOLOGICAL REVIEWS

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics

(2011) Lily Ting et al.   NATURE METHODS

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Chronicles of a death foretold: Dual sequential cell death checkpoints in TNF signaling

(2010) Marie Anne O’Donnell et al.   CELL CYCLE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression

(2010) S. L. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

Phosphorylation of the Tumor Suppressor CYLD by the Breast Cancer Oncogene IKKɛ Promotes Cell Transformation

(2009) Jessica E. Hutti et al.   MOLECULAR CELL

A Tangled Web of Ubiquitin Chains: Breaking News in TNF-R1 Signaling

(2009) Katiuscia Bianchi et al.   MOLECULAR CELL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

p38β2-Mediated Phosphorylation and Sumoylation of ATF7 Are Mutually Exclusive

(2008) Barbara Camuzeaux et al.   JOURNAL OF MOLECULAR BIOLOGY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH