Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

(2014) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

Chronic Kidney Disease Causes Disruption of Gastric and Small Intestinal Epithelial Tight Junction

(2013) Nosratola D. Vaziri et al.   AMERICAN JOURNAL OF NEPHROLOGY

MEK and the inhibitors: from bench to bedside

(2013) Akintunde Akinleye et al.   Journal of Hematology & Oncology

High-Resolution Enabled TMT 8-plexing

(2012) Thilo Werner et al.   ANALYTICAL CHEMISTRY

Increasing the Multiplexing Capacity of TMTs Using Reporter Ion Isotopologues with Isobaric Masses

(2012) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With MetastaticBRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF Inhibitor

(2012) Kevin B. Kim et al.   JOURNAL OF CLINICAL ONCOLOGY

Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC

(2012) L. L. Rosenbaek et al.   JOURNAL OF PHYSIOLOGY-LONDON

Proteomic Analysis (GeLC–MS/MS) of ePFT-Collected Pancreatic Fluid in Chronic Pancreatitis

(2012) Joao A. Paulo et al.   JOURNAL OF PROTEOME RESEARCH

Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial

(2012) Gerald S Falchook et al.   LANCET ONCOLOGY

Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules

(2012) N. Tanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

(2012) A. Garai et al.   Science Signaling

Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule

(2011) Marina Feric et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Rapid and Reproducible Single-Stage Phosphopeptide Enrichment of Complex Peptide Mixtures: Application to General and Phosphotyrosine-Specific Phosphoproteomics Experiments

(2011) Arminja N. Kettenbach et al.   ANALYTICAL CHEMISTRY

Pilot study of PD-0325901 in previously treated patients with advanced melanoma, breast cancer, and colon cancer

(2011) Peter D. Boasberg et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics

(2011) Lily Ting et al.   NATURE METHODS

Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects

(2011) Hannsjörg W. Seyberth et al.   PEDIATRIC NEPHROLOGY

Intrarenal Purinergic Signaling in the Control of Renal Tubular Transport

(2010) Helle A. Praetorius et al.   Annual Review of Physiology

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral MAPK/ERK Kinase Inhibitor PD-0325901 in Patients with Advanced Cancers

(2010) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Barttin Activates ClC-K Channel Function by Modulating Gating

(2010) M. Fischer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Modulation of ClC-K Channel Function by the Accessory Subunit Barttin

(2010) F. Lang   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer

(2009) C. Iverson et al.   CANCER RESEARCH

Vesicle-associated Membrane Protein (VAMP) Cleavage by a New Metalloprotease from the Brazilian ScorpionTityus serrulatus

(2009) Paul L. Fletcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PD0325901, a Mitogen-Activated Protein Kinase Kinase Inhibitor, Produces Ocular Toxicity in a Rabbit Animal Model of Retinal Vein Occlusion

(2009) Wenhu Huang et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse

(2009) Deanna M. Church et al.   PLOS BIOLOGY

Relative Quantification of Proteins in Human Cerebrospinal Fluids by MS/MS Using 6-Plex Isobaric Tags

(2008) Loïc Dayon et al.   ANALYTICAL CHEMISTRY

The roles of MAPKs in disease

(2008) Michael C Lawrence et al.   CELL RESEARCH

Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance

(2007) Bernhard K Krämer et al.   Nature clinical practice. Nephrology