Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2
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Title
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2
Authors
Keywords
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Journal
CELL DEATH AND DIFFERENTIATION
Volume 18, Issue 8, Pages 1376-1386
Publisher
Springer Nature
Online
2011-02-18
DOI
10.1038/cdd.2011.10
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- Smac mimetics as new cancer therapeutics
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- Human Caspases: Activation, Specificity, and Regulation
- (2009) Cristina Pop et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis
- (2009) James E. Vince et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Tangled Web of Ubiquitin Chains: Breaking News in TNF-R1 Signaling
- (2009) Katiuscia Bianchi et al. MOLECULAR CELL
- Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2
- (2008) Federica Cossu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP21
- (2008) John W. Blankenship et al. BIOCHEMICAL JOURNAL
- TNF-α Induces Two Distinct Caspase-8 Activation Pathways
- (2008) Lai Wang et al. CELL
- TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor
- (2008) Sandra Gardam et al. IMMUNITY
- c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation
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- Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment
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- cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination
- (2008) Mathieu J.M. Bertrand et al. MOLECULAR CELL
- IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis
- (2008) Mads Gyrd-Hansen et al. NATURE CELL BIOLOGY
- Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling
- (2008) Sivakumar Vallabhapurapu et al. NATURE IMMUNOLOGY
- Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
- (2008) Brian J Zarnegar et al. NATURE IMMUNOLOGY
- Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation
- (2008) D. J. Mahoney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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