Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

(2016) Ekaterina Zvezdova et al.   Science Signaling

Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

(2016) Ekaterina Zvezdova et al.   Science Signaling

Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma

(2015) Elias J. Sayour et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Transcription Factor 7 Limits Regulatory T Cell Generation in the Thymus

(2015) Melanie M. Barra et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Require TCR Signaling for Their Suppressive Function

(2015) Amanda M. Schmidt et al.   JOURNAL OF IMMUNOLOGY

An Epistatic Interaction betweenThemis1andVav1Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development

(2015) Christophe Pedros et al.   JOURNAL OF IMMUNOLOGY

The cytotoxic T cell proteome and its shaping by the kinase mTOR

(2015) Jens L Hukelmann et al.   NATURE IMMUNOLOGY

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3

(2015) Dapeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A THEMIS:SHP1 complex promotes T-cell survival

(2014) W. Paster et al.   EMBO JOURNAL

Evaluation of European coeliac disease risk variants in a north Indian population

(2014) Sabyasachi Senapati et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

(2014) J. Christoph Vahl et al.   IMMUNITY

Dendritic Cell-MHC Class II and Itk Regulate Functional Development of Regulatory Innate Memory CD4+ T Cells in Bone Marrow Transplantation

(2014) W. Huang et al.   JOURNAL OF IMMUNOLOGY

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge

(2013) Constanza Bondar et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development

(2013) W. Paster et al.   JOURNAL OF IMMUNOLOGY

Proteome Analysis of Distinct Developmental Stages of Human Natural Killer (NK) Cells

(2013) Maxi Scheiter et al.   MOLECULAR & CELLULAR PROTEOMICS

Themis sets the signal threshold for positive and negative selection in T-cell development

(2013) Guo Fu et al.   NATURE

The lymphoid lineage–specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

(2013) Yinming Liang et al.   NATURE IMMUNOLOGY

Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins with Conserved Molecular Function

(2012) R. Lesourne et al.   JOURNAL OF IMMUNOLOGY

Unique Proteomic Signatures Distinguish Macrophages and Dendritic Cells

(2012) Lev Becker et al.   PLoS One

A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease

(2012) Marianne Chabod et al.   PLoS Genetics

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

A quantitative proteomic approach for detecting protein profiles of activated human myeloid dendritic cells

(2011) Daniela M. Schlatzer et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Coronin 2A mediates actin-dependent de-repression of inflammatory response genes

(2011) Wendy Huang et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

(2011) Marc Beyer et al.   NATURE IMMUNOLOGY

Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells

(2010) Christian A. Luber et al.   IMMUNITY

Extracellular NAD+shapes the Foxp3+regulatory T cell compartment through the ART2–P2X7 pathway

(2010) Sandra Hubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis

(2010) Shahin Shafiani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Protein Tyrosine Phosphatase SHP-1 Modulates the Suppressive Activity of Regulatory T Cells

(2010) T. Iype et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

In vivo prevention of transplant arteriosclerosis by ex vivo–expanded human regulatory T cells

(2010) Satish N Nadig et al.   NATURE MEDICINE

The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1-associated death domain (TRADD)

(2009) J. J. Pointon et al.   ANNALS OF THE RHEUMATIC DISEASES

A Novel Gene Essential for the Development of Single Positive Thymocytes

(2009) K. Kakugawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Themis, a T cell–specific protein important for late thymocyte development

(2009) Renaud Lesourne et al.   NATURE IMMUNOLOGY

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

(2009) Andy L Johnson et al.   NATURE IMMUNOLOGY

Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling

(2009) Guo Fu et al.   NATURE IMMUNOLOGY

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

(2009) M. S. Patrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eos Mediates Foxp3-Dependent Gene Silencing in CD4+ Regulatory T Cells

(2009) F. Pan et al.   SCIENCE

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen Recognition

(2008) Milka Sarris et al.   IMMUNITY