Development of mouse models for analysis of human virus infections

In vivomodels of hepatitis B and C virus infection

(2016) Benjamin Y. Winer et al.   FEBS LETTERS

Experimental in vitro and in vivo models for the study of human hepatitis B virus infection

(2016) Lena Allweiss et al.   JOURNAL OF HEPATOLOGY

Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response

(2016) Hiroyuki Oshiumi et al.   Frontiers in Immunology

Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection

(2016) Takahisa Kouwaki et al.   Frontiers in Immunology

Innate detection of hepatitis B and C virus and viral inhibition of the response

(2015) Zhigang Yi et al.   CELLULAR MICROBIOLOGY

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

(2015) Seiichi Sato et al.   IMMUNITY

Proteolysis of MDA5 and IPS-1 is not required for inhibition of the type I IFN response by poliovirus

(2015) Swathi Kotla et al.   Virology Journal

HepG2 cells mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection

(2014) Benjamin Israelow et al.   HEPATOLOGY

Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models

(2014) Hiromi Takaki et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A MAVS/TICAM-1-Independent Interferon-Inducing Pathway Contributes to Regulation of Hepatitis B Virus Replication in the Mouse Hydrodynamic Injection Model

(2014) Chean Ring Leong et al.   Journal of Innate Immunity

Extensive double humanization of both liver and hematopoiesis in FRGN mice

(2014) Elizabeth M. Wilson et al.   Stem Cell Research

Human Hepatocytes and Hematolymphoid Dual Reconstitution in Treosulfan-Conditioned uPA-NOG Mice

(2013) Tanuja L. Gutti et al.   AMERICAN JOURNAL OF PATHOLOGY

Multi-Step Regulation of Interferon Induction by Hepatitis C Virus

(2013) Hiroyuki Oshiumi et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections

(2013) Keiichi Kosaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The MyD88 Pathway in Plasmacytoid and CD4+ Dendritic Cells Primarily Triggers Type I IFN Production against Measles Virus in a Mouse Infection Model

(2013) H. Takaki et al.   JOURNAL OF IMMUNOLOGY

Completion of the entire hepatitis C virus life cycle in genetically humanized mice

(2013) Marcus Dorner et al.   NATURE

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection

(2013) Li-Rung Huang et al.   NATURE IMMUNOLOGY

Chimeric Mouse Model for the Infection of Hepatitis B and C Viruses

(2013) Abeba Tesfaye et al.   PLoS One

Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse

(2012) Akihito Okazaki et al.   HEPATOLOGY

Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity

(2012) Sebastian Zeissig et al.   NATURE MEDICINE

Host factors and measles virus replication

(2012) Sebastien Delpeut et al.   Current Opinion in Virology

Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates

(2011) Kui Li et al.   HEPATOLOGY

The TLR3/TICAM-1 Pathway Is Mandatory for Innate Immune Responses to Poliovirus Infection

(2011) Hiroyuki Oshiumi et al.   JOURNAL OF IMMUNOLOGY

The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice

(2011) Y. Abe et al.   JOURNAL OF VIROLOGY

Establishment of a Novel Permissive Cell Line for the Propagation of Hepatitis C Virus by Expression of MicroRNA miR122

(2011) H. Kambara et al.   JOURNAL OF VIROLOGY

A genetically humanized mouse model for hepatitis C virus infection

(2011) Marcus Dorner et al.   NATURE

Antiviral responses induced by the TLR3 pathway

(2011) Misako Matsumoto et al.   REVIEWS IN MEDICAL VIROLOGY

Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus

(2011) Ryan S. Noyce et al.   PLoS Pathogens

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

(2010) Karl-Dimiter Bissig et al.   JOURNAL OF CLINICAL INVESTIGATION

Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential

(2010) Hiromi Takaki et al.   MOLECULAR IMMUNOLOGY

Both RIG-I and MDA5 RNA Helicases Contribute to the Induction of Alpha/Beta Interferon in Measles Virus-Infected Human Cells

(2009) S. Ikegame et al.   JOURNAL OF VIROLOGY

Cleavage of IPS-1 in Cells Infected with Human Rhinovirus

(2009) J. Drahos et al.   JOURNAL OF VIROLOGY

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

(2009) Alexander Ploss et al.   NATURE

RIG-I is cleaved during picornavirus infection

(2009) Paola M. Barral et al.   VIROLOGY

MDA5/RIG-I and virus recognition

(2008) Osamu Takeuchi et al.   CURRENT OPINION IN IMMUNOLOGY

Hepatitis C virus–infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells

(2008) Takashi Ebihara et al.   HEPATOLOGY

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE