Innate detection of hepatitis B and C virus and viral inhibition of the response

Innate immune evasion by hepatitis B virus-mediated downregulation of TRIF

(2015) Yun Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatitis C Virus Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cells and Release of Exosomes, Which Inhibits Viral Replication

(2015) Silvia Giugliano et al.   GASTROENTEROLOGY

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

(2015) Seiichi Sato et al.   IMMUNITY

Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A

(2015) Marie-Sophie Hiet et al.   JOURNAL OF HEPATOLOGY

MDA5 plays a critical role in interferon response during hepatitis C virus infection

(2015) Xuezhi Cao et al.   JOURNAL OF HEPATOLOGY

Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways

(2015) Shi Liu et al.   JOURNAL OF HEPATOLOGY

Trained immunity in newborn infants of HBV-infected mothers

(2015) Michelle Hong et al.   Nature Communications

HepG2 cells mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection

(2014) Benjamin Israelow et al.   HEPATOLOGY

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways

(2014) Yinghui Liu et al.   JOURNAL OF VIROLOGY

Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems

(2014) A. Shlomai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages

(2014) Moses T. Bility et al.   PLoS Pathogens

Reduced Toll-like receptor-3 expression in chronic hepatitis B patients and its restoration by interferon therapy

(2013) Yi-Wen Huang et al.   ANTIVIRAL THERAPY

Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver

(2013) Stefan Wieland et al.   HEPATOLOGY

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

(2013) Haitao Wen et al.   IMMUNITY

IFN-γ production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells

(2013) Shuye Zhang et al.   JOURNAL OF HEPATOLOGY

Melanoma Differentiation-Associated Gene 5 Senses Hepatitis B Virus and Activates Innate Immune Signaling To Suppress Virus Replication

(2013) H.-L. Lu et al.   JOURNAL OF IMMUNOLOGY

Hepatitis B Virus Surface Antigen Selectively Inhibits TLR2 Ligand-Induced IL-12 Production in Monocytes/Macrophages by Interfering with JNK Activation

(2013) S. Wang et al.   JOURNAL OF IMMUNOLOGY

Activation and Evasion of Antiviral Innate Immunity by Hepatitis C Virus

(2013) Stacy M. Horner   JOURNAL OF MOLECULAR BIOLOGY

Completion of the entire hepatitis C virus life cycle in genetically humanized mice

(2013) Marcus Dorner et al.   NATURE

Regulation of hepatic innate immunity by hepatitis C virus

(2013) Stacy M Horner et al.   NATURE MEDICINE

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

Humanized murine model for HBV and HCV using human induced pluripotent stem cells

(2012) Xiao-Ling Zhou et al.   ARCHIVES OF PHARMACAL RESEARCH

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

(2012) Marlène Dreux et al.   Cell Host & Microbe

Dynamic Oscillation of Translation and Stress Granule Formation Mark the Cellular Response to Virus Infection

(2012) Alessia Ruggieri et al.   Cell Host & Microbe

Human Type 2 Myeloid Dendritic Cells Produce Interferon-λ and Amplify Interferon-α in Response to Hepatitis C Virus Infection

(2012) Shuye Zhang et al.   GASTROENTEROLOGY

Hepatitis B virus polymerase impairs interferon-α-induced STA T activation through inhibition of importin-α5 and protein kinase C-δ

(2012) Jieliang Chen et al.   HEPATOLOGY

CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of hepatitis C virus-infected cells and induction of interferon-alpha

(2012) Shuye Zhang et al.   HEPATOLOGY

Hepatitis C Virus (HCV) Induces Formation of Stress Granules Whose Proteins Regulate HCV RNA Replication and Virus Assembly and Egress

(2012) U. Garaigorta et al.   JOURNAL OF VIROLOGY

HBsAg Inhibits IFN-α Production in Plasmacytoid Dendritic Cells through TNF-α and IL-10 Induction in Monocytes

(2012) Bisheng Shi et al.   PLoS One

Stochastic Expression of the Interferon-β Gene

(2012) Mingwei Zhao et al.   PLOS BIOLOGY

Hepatitis B Virus Limits Response of Human Hepatocytes to Interferon-α in Chimeric Mice

(2011) Marc Lütgehetmann et al.   GASTROENTEROLOGY

Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates

(2011) Kui Li et al.   HEPATOLOGY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway

(2011) Tali Lang et al.   JOURNAL OF HEPATOLOGY

Hepatitis B Virus Lacks Immune Activating Capacity, but Actively Inhibits Plasmacytoid Dendritic Cell Function

(2011) Andrea M. Woltman et al.   PLoS One

Hepatitis B Virus Impairs TLR9 Expression and Function in Plasmacytoid Dendritic Cells

(2011) Isabelle E. Vincent et al.   PLoS One

Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses

(2010) Roberto Lande et al.   Annals of the New York Academy of Sciences

Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-β induction by disrupting the VISA-associated complex

(2010) Xianmiao Wang et al.   Cellular & Molecular Immunology

Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice

(2010) M. Lech et al.   INTERNATIONAL IMMUNOLOGY

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKK  and DDX3

(2010) S. Yu et al.   JOURNAL OF GENERAL VIROLOGY

The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein

(2010) C. Wei et al.   JOURNAL OF IMMUNOLOGY

Hepatitis B Virus Regulatory HBx Protein Binds to Adaptor Protein IPS-1 and Inhibits the Activation of Beta Interferon

(2010) M. Kumar et al.   JOURNAL OF VIROLOGY

Innate Antiviral Immune Responses to Hepatitis B Virus

(2010) Malika Ait-goughoulte et al.   Viruses-Basel

Hepatitis B Virus Polymerase Blocks Pattern Recognition Receptor Signaling via Interaction with DDX3: Implications for Immune Evasion

(2010) Haifeng Wang et al.   PLoS Pathogens

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

Temporal Analysis of Early Immune Responses in Patients With Acute Hepatitis B Virus Infection

(2009) Claire Dunn et al.   GASTROENTEROLOGY

Early kinetics of innate and adaptive immune responses during hepatitis B virus infection

(2009) P Fisicaro et al.   GUT

Control of hepatitis B virus replication by innate response of HepaRG cells

(2009) Julie Lucifora et al.   HEPATOLOGY

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection

(2009) Marianna Hösel et al.   HEPATOLOGY

Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system

(2009) Pantxika Bellecave et al.   HEPATOLOGY

Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication

(2009) Bo Wang et al.   JOURNAL OF HEPATOLOGY

Intracellular Innate Immune Cascades and Interferon Defenses That Control Hepatitis C Virus

(2009) Stacy M. Horner et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

HBsAg inhibits TLR9-mediated activation and IFN-α production in plasmacytoid dendritic cells

(2009) Yongfen Xu et al.   MOLECULAR IMMUNOLOGY

Characterization of the double-stranded RNA responses in human liver progenitor cells

(2008) Magali Maire et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients

(2008) Zhiao Chen et al.   CLINICAL IMMUNOLOGY

Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

(2008) Jun Wu et al.   HEPATOLOGY

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Characterization of the innate immune signalling pathways in hepatocyte cell lines

(2008) S. Preiss et al.   JOURNAL OF VIRAL HEPATITIS

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE