Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 53, Issue -, Pages 329-333Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2014.05.001
Keywords
Dendritic cells; Measles virus; Mouse model; Type I interferon (IFN); Immune suppression
Categories
Funding
- Ministry of Education, Science, and Culture (Specified Project for 'Carcinogenic Spiral')
- Ministry of Health, Labor, and Welfare of Japan
- Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases
- Japan Society for the promotion of Science Fellows [21-1368]
- Grants-in-Aid for Scientific Research [13J40020, 26860593, 24590570] Funding Source: KAKEN
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Measles caused by measles virus (MV) infection remains important in child mortality. Although the natural host of MV is human, mouse models expressing MV entry receptors (human CD46, CD150) and disrupting the interferon (IFN) pathways work for investigating immune responses during early MV infection in vivo. Dendritic cells (DCs) are primary targets for MV in the mouse models and are efficiently infected with several MV strains in the respiratory tract in vivo. However, questions remain about what kind of DC in a variety of DC subsets is involved in initial MV infection and how the RNA sensors evoke circumventing signals against MV in infected DCs. Since type I IFN-inducing pathways are a pivotal defense system that leads to the restriction of systemic viral infection, we have generated CD150-transgenic mice with disrupting each of the IFN-inducing pathway, and clarified that DC subsets had subset-specific IFN-inducing systems, which critically determined the DC's differential susceptibility to MV. (C) 2014 Elsevier Ltd. All rights reserved.
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