Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies

The path to producing pharmaceuticals from natural products uncovered by academia—from the perspective of a science coordinator

(2016) Akihiko Fujie   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Oxidative Cyclization in Natural Product Biosynthesis

(2016) Man-Cheng Tang et al.   CHEMICAL REVIEWS

Family-wide Structural Characterization and Genomic Comparisons Decode the Diversity-oriented Biosynthesis of Thalassospiramides by Marine Proteobacteria

(2016) Weipeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simultaneous biosynthesis of putrebactin, avaroferrin and bisucaberin by Shewanella putrefaciens and characterisation of complexes with iron(III), molybdenum(VI) or chromium(V)

(2016) Cho Zin Soe et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Enzymatic Reductive Dehalogenation Controls the Biosynthesis of Marine Bacterial Pyrroles

(2016) Abrahim El Gamal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spotlight on Antimicrobial Metabolites from the Marine Bacteria Pseudoalteromonas: Chemodiversity and Ecological Significance

(2016) Clément Offret et al.   Marine Drugs

Isolation and Biosynthetic Analysis of Haliamide, a New PKS-NRPS Hybrid Metabolite from the Marine Myxobacterium Haliangium ochraceum

(2016) Yuwei Sun et al.   MOLECULES

Unique marine derived cyanobacterial biosynthetic genes for chemical diversity

(2016) Karin Kleigrewe et al.   NATURAL PRODUCT REPORTS

Marine natural products

(2016) John W. Blunt et al.   NATURAL PRODUCT REPORTS

A pyridoxal phosphate–dependent enzyme that oxidizes an unactivated carbon-carbon bond

(2016) Yi-Ling Du et al.   Nature Chemical Biology

The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

(2016) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase–thioesterase enzyme pair

(2016) Abrahim El Gamal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink

(2016) Maxwell Z. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterologous Production of the Marine Myxobacterial Antibiotic Haliangicin and Its Unnatural Analogues Generated by Engineering of the Biochemical Pathway

(2016) Yuwei Sun et al.   Scientific Reports

Enzymatic Basis of “Hybridity” in Thiomarinol Biosynthesis

(2015) Zachary D. Dunn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthetic Manipulation of Tryptophan in Bacteria: Pathways and Mechanisms

(2015) Lona M. Alkhalaf et al.   CHEMISTRY & BIOLOGY

Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome

(2015) Lena Keller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Taxonomy, Physiology, and Natural Products of Actinobacteria

(2015) Essaid Ait Barka et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Modulation of violacein production and phenotypes associated with biofilm by exogenous quorum sensing N-acylhomoserine lactones in the marine bacterium Pseudoalteromonas ulvae TC14

(2015) Armande Mireille Ayé et al.   MICROBIOLOGY-SGM

Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins

(2015) Stella Cascioferro et al.   MOLECULES

Marine natural products

(2015) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B

(2015) Malia B Potts et al.   Nature Chemical Biology

Computational approaches to natural product discovery

(2015) Marnix H Medema et al.   Nature Chemical Biology

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Highly efficient CRISPR/Cas9-mediated TAR cloning of genes and chromosomal loci from complex genomes in yeast

(2015) Nicholas C.O. Lee et al.   NUCLEIC ACIDS RESEARCH

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly

(2015) Yi-Ling Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Action of Thalassospiramides, A New Class of Calpain Inhibitors

(2015) Liang Lu et al.   Scientific Reports

Enzymatic Synthesis of Polybrominated Dioxins from the Marine Environment

(2014) Vinayak Agarwal et al.   ACS Chemical Biology

A Chimeric Siderophore Halts SwarmingVibrio

(2014) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of Phenylnannolone A, a Multidrug Resistance Reversal Agent from the Halotolerant MyxobacteriumNannocystis pusillaB150

(2014) Sarah M. Bouhired et al.   CHEMBIOCHEM

Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

(2014) Nelson L. Brock et al.   CHEMICAL COMMUNICATIONS

Scrutinizing the Scaffolds of Marine Biosynthetics from Different Source Organisms: Gram-Negative Cultured Bacterial Products Enter Center Stage

(2014) Patrick C. Still et al.   JOURNAL OF NATURAL PRODUCTS

Marine natural products

(2014) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Biosynthesis of polybrominated aromatic organic compounds by marine bacteria

(2014) Vinayak Agarwal et al.   Nature Chemical Biology

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

(2014) Kazuya Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Capture and Heterologous Expression of the Pseudoalteromonas Alterochromide Gene Cluster in Escherichia coli Represents a Promising Natural Product Exploratory Platform

(2014) Avena C. Ross et al.   ACS Synthetic Biology

Protection of cod larvae from vibriosis by Phaeobacter spp.: A comparison of strains and introduction times

(2013) Paul W. D'Alvise et al.   AQUACULTURE

Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution

(2013) Hiroaki Naka et al.   BIOMETALS

Heterologous Production of Desferrioxamines with a Fusion Biosynthetic Gene Cluster

(2013) Masaki J. FUJITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Thalassospiramide G, a New γ-Amino-Acid-Bearing Peptide from the Marine Bacterium Thalassospira sp.

(2013) Soohyun Um et al.   Marine Drugs

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi

(2013) Yit-Heng Chooi et al.   ORGANIC LETTERS

New rRNA Gene-Based Phylogenies of the Alphaproteobacteria Provide Perspective on Major Groups, Mitochondrial Ancestry and Phylogenetic Instability

(2013) Matteo P. Ferla et al.   PLoS One

MS/MS networking guided analysis of molecule and gene cluster families

(2013) D. D. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp. SANK 73390

(2013) Annabel C. Murphy et al.   Chemical Science

Genetic Analysis of the Upper Phenylacetate Catabolic Pathway in the Production of Tropodithietic Acid by Phaeobacter gallaeciensis

(2012) Martine Berger et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Shiga Toxin-Producing Escherichia coli O104:H4: a New Challenge for Microbiology

(2012) Maite Muniesa et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synthesis and antibacterial activity of conjugates between norfloxacin and analogues of the siderophore vanchrobactin

(2012) Alba Souto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Coupling Reaction of Indolepyruvic Acid by StaD and Its Product: Implications for Biosynthesis of Indolocarbazole and Violacein

(2012) Shumpei Asamizu et al.   CHEMBIOCHEM

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

(2012) Rainer Wilcken et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flavoenzyme-Catalyzed Atropo-Selective N,C-Bipyrrole Homocoupling in Marinopyrrole Biosynthesis

(2012) Kazuya Yamanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacterial Biosynthesis and Maturation of the Didemnin Anti-cancer Agents

(2012) Ying Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthetic Multitasking Facilitates Thalassospiramide Structural Diversity in Marine Bacteria

(2012) Avena C. Ross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Didemnins, tamandarins and related natural products

(2012) Jisun Lee et al.   NATURAL PRODUCT REPORTS

Marine natural products

(2012) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390

(2011) Annabel C. Murphy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Violacein and related tryptophan metabolites produced by Chromobacterium violaceum: biosynthetic mechanism and pathway for construction of violacein core

(2011) Tsutomu Hoshino   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Mupirocin: biosynthesis, special features and applications of an antibiotic from a Gram-negative bacterium

(2011) Rachel Gurney et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of a gene cluster and its putative promoter region for violacein biosynthesis in Pseudoalteromonas sp. 520P1

(2011) Xi Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Diversity of DMSP transport in marine bacteria, revealed by genetic analyses

(2011) Lei Sun et al.   BIOGEOCHEMISTRY

Cloning and Heterologous Expression of the Vibrioferrin Biosynthetic Gene Cluster from a Marine Metagenomic Library

(2011) Masaki J. FUJITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Marine natural products: a new wave of drugs?

(2011) Rana Montaser et al.   Future Medicinal Chemistry

Studies on the Mechanism of Ring Hydrolysis in Phenylacetate Degradation

(2011) Robin Teufel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Production of the Tunicate-Derived Antitumor Cyclic Depsipeptide Didemnin B

(2011) Moriya Tsukimoto et al.   JOURNAL OF NATURAL PRODUCTS

Comparative Characterization of Fungal Anthracenone and Naphthacenedione Biosynthetic Pathways Reveals an α-Hydroxylation-Dependent Claisen-like Cyclization Catalyzed by a Dimanganese Thioesterase

(2011) Yanran Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Purple-Pigmented Violacein-Producing Duganella spp. Inhabit the Rhizosphere of Wild and Cultivated Olives in Southern Spain

(2011) Sergio Aranda et al.   MICROBIAL ECOLOGY

Heterologous production of bisucaberin using a biosynthetic gene cluster cloned from a deep sea metagenome

(2011) Masaki J. Fujita et al.   Molecular BioSystems

Marine natural products

(2011) John W. Blunt et al.   NATURAL PRODUCT REPORTS

A natural prodrug activation mechanism in nonribosomal peptide synthesis

(2011) Daniela Reimer et al.   Nature Chemical Biology

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic

(2011) Daisuke Fukuda et al.   PLoS One

Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases and Fatty Acid Synthase

(2010) Shane R. Wesener et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Nonribosomal peptide synthetases: structures and dynamics

(2010) Matthias Strieker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Phylogeny of Gammaproteobacteria

(2010) K. P. Williams et al.   JOURNAL OF BACTERIOLOGY

Vanchrobactin and Anguibactin Siderophores Produced byVibriosp. DS40M4

(2010) Moriah Sandy et al.   JOURNAL OF NATURAL PRODUCTS

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A sea of biosynthesis: marine natural products meet the molecular age

(2010) Amy L. Lane et al.   NATURAL PRODUCT REPORTS

Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete genome sequence of Haliangium ochraceum type strain (SMP-2T)

(2010) Natalia Ivanova et al.   Standards in Genomic Sciences

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reconstruction of the violacein biosynthetic pathway from Duganella sp. B2 in different heterologous hosts

(2009) Pei-xia Jiang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Microbial Iron Acquisition: Marine and Terrestrial Siderophores

(2009) Moriah Sandy et al.   CHEMICAL REVIEWS

Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms

(2009) P. D. Lister et al.   CLINICAL MICROBIOLOGY REVIEWS

Fodinicurvata sediminis gen. nov., sp. nov. and Fodinicurvata fenggangensis sp. nov., poly- -hydroxybutyrate-producing bacteria in the family Rhodospirillaceae

(2009) Y.-X. Wang et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Polyketide Decarboxylative Chain Termination Preceded byO-Sulfonation in Curacin A Biosynthesis

(2009) Liangcai Gu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GatekeepingversusPromiscuity in the Early Stages of the Andrimid Biosynthetic Assembly Line

(2008) Nathan A. Magarvey et al.   ACS Chemical Biology

PCR Detection of Type I Polyketide Synthase Genes in Myxobacteria

(2008) H. Komaki et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Quorum Sensing Signaling Molecules Involved in the Production of Violacein byPseudoalteromonas

(2008) Yi WANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

In vivo Mutational Analysis of the Mupirocin Gene Cluster Reveals Labile Points in the Biosynthetic Pathway: the “Leaky Hosepipe” Mechanism

(2008) Ji'en Wu et al.   CHEMBIOCHEM

Phenylnannolones A-C: Biosynthesis of New Secondary Metabolites from the MyxobacteriumNannocystis exedens

(2008) Birgit Ohlendorf et al.   CHEMBIOCHEM

Bisucaberin biosynthesis: an adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine

(2008) Nadia Kadi et al.   CHEMICAL COMMUNICATIONS

Crystal Structure of VioE, a Key Player in the Construction of the Molecular Skeleton of Violacein

(2008) Satoshi Hirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Violacein Biosynthetic Enzyme VioE Shares a Fold with Lipoprotein Transporter Proteins

(2008) Katherine S. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Gene Cluster That Directs Putrebactin Biosynthesis inShewanellaSpecies: PubC Catalyzes Cyclodimerization ofN-Hydroxy-N-succinylputrescine

(2008) Nadia Kadi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nonribosomal Peptide Synthetases Involved in the Production of Medically Relevant Natural Products

(2008) Elizabeth A. Felnagle et al.   MOLECULAR PHARMACEUTICS

Isoprenoid-like alkylations in polyketide biosynthesis

(2008) Christopher T. Calderone   NATURAL PRODUCT REPORTS

Selective isolation of genomic loci from complex genomes by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae

(2008) Natalay Kouprina et al.   Nature Protocols

DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways

(2008) Zengyi Shao et al.   NUCLEIC ACIDS RESEARCH