Journal
FEBS LETTERS
Volume 584, Issue 11, Pages 2168-2175Publisher
WILEY
DOI: 10.1016/j.febslet.2010.03.035
Keywords
Lipid droplet; Live microscopy; Biogenesis; Targeting
Funding
- German research foundation [FU 340/5-1, EH 196/5-1]
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Lipid droplets emerge as important intracellular organelles relevant for lipid homeostasis and the pathophysiology of metabolic diseases. Here, we present a personal view on the current knowledge about the biogenesis of mammalian cytoplasmic lipid droplets, with a focus on microscopy and especially live imaging. We also discuss difficulties related to the lipid droplet proteome, contentious views on lipid droplet growth, and last but not least the evidence for the heterogeneity of lipid droplets within a single cell. We conclude with an outline of the most important future challenges. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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