Phosphorylated mTOR and YAP serve as prognostic markers and therapeutic targets in gliomas

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

PI3K–mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models

(2016) Fan Lin et al.   CLINICAL CANCER RESEARCH

Targeted Therapeutics in Patients With High-Grade Gliomas: Past, Present, and Future

(2016) Ricky Chen et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Recent Advances on the Molecular Pathology of Glial Neoplasms in Children and Adults

(2016) Fausto J. Rodriguez et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Characterization of Hippo Pathway Components by Gene Inactivation

(2016) Steven W. Plouffe et al.   MOLECULAR CELL

Moving the needle: Optimizing classification for glioma

(2016) Roel G. W. Verhaak   Science Translational Medicine

PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

(2016) Xiaoman Li et al.   Oncotarget

Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling

(2016) Nicholas Nelson et al.   Oncotarget

Molecular and Genomic Alterations in Glioblastoma Multiforme

(2015) Ines Crespo et al.   AMERICAN JOURNAL OF PATHOLOGY

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

(2015) Andras Perl   Annals of the New York Academy of Sciences

Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1

(2015) Jun Rao et al.   CANCER LETTERS

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

(2015) Carsten Gram Hansen et al.   CELL RESEARCH

miR-663 Suppresses Oncogenic Function of CXCR4 in Glioblastoma

(2015) Y. Shi et al.   CLINICAL CANCER RESEARCH

Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides

(2015) Zheng Zhou et al.   FASEB JOURNAL

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

(2015) Yun-Yong Park et al.   HEPATOLOGY

Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness

(2015) Nicholas Artinian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

American Brain Tumor Association Adolescent and Young Adult Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

(2015) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

(2014) Ning Liang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mst1 regulates glioma cell proliferation via the AKT/mTOR signaling pathway

(2014) Yuewen Chao et al.   JOURNAL OF NEURO-ONCOLOGY

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Critical functions of RhoB in support of glioblastoma tumorigenesis

(2014) Yufang Ma et al.   NEURO-ONCOLOGY

Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02

(2014) P. Y. Wen et al.   NEURO-ONCOLOGY

Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

(2014) Zhisen Zhang et al.   ACS Medicinal Chemistry Letters

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Hippo–YAP and mTOR pathways collaborate to regulate organ size

(2012) Alfred Csibi et al.   NATURE CELL BIOLOGY

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

(2012) Karen Tumaneng et al.   NATURE CELL BIOLOGY

Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end?

(2012) Shota Tanaka et al.   Nature Reviews Clinical Oncology

Inhibition of mTOR Kinase by AZD8055 Can Antagonize Chemotherapy-induced Cell Death through Autophagy Induction and Down-regulation of p62/Sequestosome 1

(2011) Shengbing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling

(2011) Yi-fang Ping et al.   JOURNAL OF PATHOLOGY

Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation

(2011) A Fernandez-L et al.   ONCOGENE

Combination of Temsirolimus (CCI-779) with Chemoradiation in Newly Diagnosed Glioblastoma Multiforme (GBM) (NCCTG trial N027D) Is Associated with Increased Infectious Risks

(2010) J. N. Sarkaria et al.   CLINICAL CANCER RESEARCH

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

North Central Cancer Treatment Group Phase I Trial N057K of Everolimus (RAD001) and Temozolomide in Combination With Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme

(2010) Jann N. Sarkaria et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

(2008) S. W. Chan et al.   CANCER RESEARCH

Expression of Yes-associated protein in common solid tumors

(2008) Angela A. Steinhardt et al.   HUMAN PATHOLOGY