Article
Chemistry, Applied
Jean-Paul Kestemont, James R. Frost, Jerome Jacq, Patrick Pasau, Frederic Perl, Julien Brown, Matthieu Tissot
Summary: We present a large-scale carboxylation of N-Boc-4,4-difluoropiperidine (1) enabled by a continuous flow process. The flow process involved N-Boc-directed alpha-deprotonation using s-BuLi in THF and subsequent trapping with CO2 gas. Flow chemistry allowed for safe and scalable preparation of 400 g of carboxylic acid 2 in a day to support our medicinal chemistry research program.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Review
Pharmacology & Pharmacy
Maria Camilla Operti, Alexander Bernhardt, Silko Grimm, Andrea Engel, Carl Gustav Figdor, Oya Tagit
Summary: Nanomedicines based on PLGA carriers show great potential for biomedical research, but are not yet available on the global market. Challenges include scaling up production and successful translation into clinical practice, requiring advancements in manufacturing techniques and quality control methods.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Dan Zhang, Lin Liu, Jian Wang, Hong Zhang, Zhuo Zhang, Gang Xing, Xuan Wang, Minghua Liu
Summary: Nanoparticles based on PLGA and PEG-PLGA have been extensively studied for drug delivery in cancer treatment. These nanoparticles can encapsulate and release various drugs, and their surface can be modified with ligands for active tumor targeting. This review provides an overview of the synthesis, application, and recent advances of PEG-PLGA nanoparticles in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hani Z. Asfour, Nabil A. Alhakamy, Osama A. A. Ahmed, Usama A. Fahmy, Mohamed A. El-moselhy, Waleed Y. Rizg, Adel F. Alghaith, Basma G. Eid, Ashraf B. Abdel-Naim
Summary: This study developed a new nanoformula called Amitrip-based biodegradable PEG-PLGA self-assembled nanoparticles (Amitrip-NPs), which expedited wound healing in diabetic rats and exhibited anti-inflammatory, antioxidant, pro-collagen, and angiogenic activities.
Article
Nanoscience & Nanotechnology
Sara Gimondi, Carlos F. Guimaraes, Sara F. Vieira, Virginia M. F. Goncalves, Maria E. Tiritan, Rui L. Reis, Helena Ferreira, Nuno M. Neves
Summary: Polymeric nanoparticles with well-controlled sizes were produced using a microfluidic device. The study explored the influence of several parameters on the synthesis process and evaluated the cytocompatibility and drug carrier efficacy of the nanoparticles. The results demonstrated the importance of nanoparticle size in drug encapsulation, release, and overall biological efficacy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Juliana Palacio, Yuliana Monsalve, Janny A. Villa-Pulgarin, Katherin V. Contreras Ramirez, Carlos E. Navarro Chica, Ligia Sierra, Betty L. Lopez
Summary: In this study, the encapsulation of Gusperimus in PLGA-PEG nanoparticles was investigated to achieve controlled release and protect its stability and bioactivity. The effects of different surfactants and polymer concentrations on the properties of the nanoparticles were evaluated. The results showed that the system prepared with 1.7% w/v PLGA-PEG and 1% w/v Pluronic (R) F127 had the smallest particle size and higher colloidal stability. The nanoparticles exhibited high encapsulation efficiency and load capacity, as well as anti-inflammatory effects in macrophages.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Environmental
Gang Fu, Lei Ni, Dan Wei, Juncheng Jiang, Zhiquan Chen, Yong Pan
Summary: In this study, the scaling up of toluene nitration in a meso-scale flow reactor was conducted with consideration of safety. The exothermic characteristic of the reaction was demonstrated and numerical simulation was used to study the hydrodynamics. The effects of flow rates, temperatures, and molar ratios on the reaction were analyzed, and a comparison between batch calorimeter and flow reactor performances was presented.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Engineering, Biomedical
Paul Robert Neumann, Frank Erdmann, Joost Holthof, Gabriela Haedrich, Mark Green, Jianghong Rao, Lea Ann Dailey
Summary: This study investigated the use of PCPDTBT as a contrast agent for optical imaging, examining the impact of different encapsulation methods on imaging performance, biodistribution, and biocompatibility. Results showed that formulations have a significant impact on both imaging performance and biodistribution, indicating the importance of further exploration in this area.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Chemical
Ahmed Yusuf, Giovanni Palmisano
Summary: This paper presents the estimation of adsorption rate and apparent kinetic rate constants for 4-nitrophenol photodegradation in a recirculating and single-pass photocatalytic microreactor using simulated solar radiation. Results show the promising application of microreactors in heterogeneous photocatalysis for wastewater treatment.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Xintong Huang, Shunkai Xia, Seoyeon Lee, Yongqi Jia, Zhuo Chen, Jianhong Xu
Summary: A droplet-based microreactor system was designed to overcome the low efficiency of mass and heat transfer in conventional batch synthesis of Ag NPs. By regulating residence time and introducing seed-mediated growth, continuous and controllable synthesis of Ag NPs with sizes ranging from 7 to 30 nm, polydispersity indexes less than 10%, and high stability were achieved. This system provides a diffusion-limited reaction model for the synthesis of metal nanomaterials.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Moxia Li, Yaomengli Xu, Bingwu Liu, Jianfang Liu, Xuguang Sun, Dongmei Deng, Xidong Duan, Jiawen Hu
Summary: This article presents a bottom-up nanowelding strategy for the fabrication of high-purity nanoporous gold (NPG) from gold nanoparticles (NPs). By transferring the layered Au NP film onto a solid substrate and conducting direct current (DC) nanowelding, NPG can be produced at low temperatures within 10 seconds without damaging the spherical structure. This method also allows for the tunability of thickness, ligament size, and pore size by using differently sized Au NPs as starting building blocks, providing great flexibility for creating functional porous nanomaterials.
SCIENCE CHINA-MATERIALS
(2022)
Article
Acoustics
Jiahong Xu, Xiaojing Zhu, Jie Zhang, Zhipeng Li, Wenjiang Kang, Haibo He, Zhilin Wu, Zhengya Dong
Summary: In this study, a high-efficient ultrasonic microreactor (USMR) was used to continuously produce unified oil-in-water nanoemulsions in a single cycle. The emulsification was optimized to obtain nanoemulsions with uniform morphology and superior stability. This work provides a typical paradigm for preparing functional nanomaterials based on novel and efficient emulsification tools.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Biochemical Research Methods
Peer Erfle, Juliane Riewe, Heike Bunjes, Andreas Dietzel
Summary: The coaxial lamination mixer (CLM) enables efficient production of stable, scalable lipid nanoparticles loaded with poorly soluble drugs, ensuring high throughput parallelization.
Article
Pharmacology & Pharmacy
Isaac H. Caballero-Floran, Hernan Cortes, Fabiola V. Borbolla-Jimenez, Carla D. Floran-Hernandez, Maria L. Del Prado-Audelo, Jonathan J. Magana, Benjamin Floran, Gerardo Leyva-Gomez
Summary: This study proposes the use of polyethylene glycol 400 (PEG) and trehalose as a surface modification technique to improve PLGA-based nanoparticles as drug carriers for neurons. The combination of PEG and trehalose enhances the hydrophilicity of the nanoparticles and promotes their cellular internalization. Through optimization using central composite design, PLGA nanoparticles with diameters smaller than 200 nm were produced, and the coating process did not significantly increase their size. The nanoparticles showed high curcumin entrapment efficiency and a controlled release profile.
Article
Engineering, Civil
Jiayun Li, Chuanhao Wu, Chuan-An Xia, Pat J-F Yeh, Bei Chen, Wenhan Lv, Bill X. Hu
Summary: The voxel-based three-dimensional FD (V3DFD) method provides a better understanding of the spatio-temporal dynamics and recovery of flash drought events. In China, Guangdong and Guangxi experience more frequent and longer-lasting flash droughts compared to Yunnan and Guizhou.
JOURNAL OF HYDROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yeong Hun Kim, Sang Gu Kwon, Seo Jun Bae, Sung Jin Park, Do Jin Im
BIOELECTROCHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Hyune-Jea Lee, Robert C. Roberts, Do Jin Im, Se-Jun Yim, Heejin Kim, Ji Tae Kim, Dong-Pyo Kim
Article
Chemistry, Multidisciplinary
Do Jin Im
Article
Chemistry, Multidisciplinary
Seok Hwan Yang, Do Jin Im
Article
Chemistry, Physical
Minki Jun, Changmo Kwak, Si Young Lee, Jinwhan Joo, Ji Min Kim, Do Jin Im, Min Kyung Cho, Hionsuck Baik, Yun Jeong Hwang, Heejin Kim, Kwangyeol Lee
Summary: This study reports the synthesis of a unique hierarchical structure of Cu2O with multiple stepped surfaces via flow chemistry. The hierarchical Cu2O structure facilitates C-C bond formation and enhances ethylene production during CO2 electrochemical reduction.
Article
Engineering, Chemical
Tae Yeon Kong, Byungtae Ryu, Gilhwan Ahn, Do Jin Im
Summary: This article emphasizes the importance of modeling the energy release performance of energetic material combustion in closed systems. It proposes a theoretical model for estimating the energy release performance of mixed energetic materials and validates the model through parameter analysis and experiments.
KOREAN CHEMICAL ENGINEERING RESEARCH
(2022)
Article
Engineering, Chemical
Seo Jun Bae, Do Jin Im
Summary: In this study, the post-processing methods of the stereolithography (SLA) printing method were compared to assess their effects on the surface properties. It was found that polishing could improve transparency, although achieving glass-like transparency was challenging. The use of a commercially available vehicle scratch remover or silicone oil could effectively enhance transparency. A method combining sequential grinding with a scratch remover was proposed for achieving high transparency. However, it was difficult to achieve a contact angle of 90 degrees or more, even with various surface treatment methods.
KOREAN CHEMICAL ENGINEERING RESEARCH
(2022)
Article
Engineering, Chemical
Seo Jun Bae, Do Jin Im
KOREAN CHEMICAL ENGINEERING RESEARCH
(2020)
Article
Engineering, Chemical
Seo Jun Bae, Do Jin Im
KOREAN CHEMICAL ENGINEERING RESEARCH
(2019)
Article
Engineering, Chemical
Seo Jun Bae, Do Jin Im
KOREAN CHEMICAL ENGINEERING RESEARCH
(2019)
Correction
Chemistry, Multidisciplinary
Dong-Heon Ha, Dong-Hyeon Ko, Jin-Oh Kim, Do Jin Im, Byoung Soo Kim, Soo-Young Park, Steve Park, Dong-Pyo Kim, Dong-Woo Cho
Article
Engineering, Chemical
Chang Yong Choi, Do Jin Im
KOREAN CHEMICAL ENGINEERING RESEARCH
(2018)
Article
Engineering, Chemical
Do Jin Im
KOREAN CHEMICAL ENGINEERING RESEARCH
(2018)
Article
Chemistry, Multidisciplinary
Dong-Heon Ha, Dong-Hyeon Ko, Jin-oh Kim, Do Jin Im, Byoung Soo Kim, Soo-Young Park, Steve Park, Dong-Pyo Kim, Dong-Woo Cho
Article
Chemistry, Analytical
Byeong Sun Yoo, Do Jin Im, Myung Mo Ahn, Sung Jin Park, Yeong Hun Kim, Tae Woong Um, In Seok Kang
