Systematic heterogenization for better reproducibility in animal experimentation

More than 3Rs: the importance of scientific validity for harm-benefit analysis of animal research

(2017) Hanno Würbel   LAB ANIMAL

Improving quality of science through better animal welfare: the NC3Rs strategy

(2017) Mark J Prescott et al.   LAB ANIMAL

Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation

(2017) Jeffrey S Mogil   LAB ANIMAL

Introducing Therioepistemology: the study of how knowledge is gained from animal research

(2017) Joseph P Garner et al.   LAB ANIMAL

Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and reduction

(2016) Michael Walker et al.   BMC Medical Research Methodology

1,500 scientists lift the lid on reproducibility

(2016) Monya Baker   NATURE

Genetic Background Limits Generalizability of Genotype-Phenotype Relationships

(2016) Laura J. Sittig et al.   NEURON

Aligning statistical and scientific reasoning

(2016) Steven N. Goodman   SCIENCE

Irreproducibility in Preclinical Biomedical Research: Perceptions, Uncertainties, and Knowledge Gaps

(2016) Michael F. Jarvis et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Reproducibility Crisis: Are We Ignoring Reaction Norms?

(2016) Bernhard Voelkl et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor

(2016) Lucile Vogt et al.   PLOS BIOLOGY

When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

(2016) Jack W. Scannell et al.   PLoS One

The Researchers’ View of Scientific Rigor—Survey on the Conduct and Reporting of In Vivo Research

(2016) Thomas S. Reichlin et al.   PLoS One

The fickle P value generates irreproducible results

(2015) Lewis G Halsey et al.   NATURE METHODS

Estimating the reproducibility of psychological science

(2015)   SCIENCE

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

(2015) Malcolm R. Macleod et al.   PLOS BIOLOGY

The Extent and Consequences of P-Hacking in Science

(2015) Megan L. Head et al.   PLOS BIOLOGY

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

Refinement of Experimental Design and Conduct in Laboratory Animal Research

(2014) J. D. Bailoo et al.   ILAR JOURNAL

Increasing value and reducing waste in research design, conduct, and analysis

(2014) John P A Ioannidis et al.   LANCET

Scientific method: Statistical errors

(2014) Regina Nuzzo   NATURE

Policy: NIH plans to enhance reproducibility

(2014) Francis S. Collins et al.   NATURE

Olfactory exposure to males, including men, causes stress and related analgesia in rodents

(2014) Robert E Sorge et al.   NATURE METHODS

Journals unite for reproducibility

(2014) M. McNutt   SCIENCE

Touchscreen-paradigm for mice reveals cross-species evidence for an antagonistic relationship of cognitive flexibility and stability

(2014) S. Helene Richter et al.   Frontiers in Behavioral Neuroscience

Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies

(2014) David Baker et al.   PLOS BIOLOGY

Improving basic and translational science by accounting for litter-to-litter variation in animal models

(2013) Stanley E Lazic et al.   BMC NEUROSCIENCE

Touching on translation

(2013) John Talpos et al.   CELL AND TISSUE RESEARCH

Reanalysis of Richter et al. (2010) on reproducibility

(2013) Russell D Wolfinger   NATURE METHODS

Does systematic variation improve the reproducibility of animal experiments?

(2013) Rudy M Jonker et al.   NATURE METHODS

Reply to: "Reanalysis of Richter et al. (2010) on reproducibility"

(2013) Hanno Würbel et al.   NATURE METHODS

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Robust and Sensitive Analysis of Mouse Knockout Phenotypes

(2012) Natasha A. Karp et al.   PLoS One

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of Population Heterogenization on the Reproducibility of Mouse Behavior: A Multi-Laboratory Study

(2011) S. Helene Richter et al.   PLoS One

The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis?

(2010) Stanley E Lazic   BMC NEUROSCIENCE

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Systematic variation improves reproducibility of animal experiments

(2010) S Helene Richter et al.   NATURE METHODS

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Evaluation of animal models of neurobehavioral disorders

(2009) F Josef van der Staay et al.   Behavioral and Brain Functions

How does multiple testing correction work?

(2009) William S Noble   NATURE BIOTECHNOLOGY

Repeatability of published microarray gene expression analyses

(2009) John P A Ioannidis et al.   NATURE GENETICS

Questioning standardization in science

(2009) Richard Paylor   NATURE METHODS

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

(2009) S Helene Richter et al.   NATURE METHODS

Behavioural reaction norms: animal personality meets individual plasticity

(2009) Niels J. Dingemanse et al.   TRENDS IN ECOLOGY & EVOLUTION

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study

(2008) Silvia Mandillo et al.   PHYSIOLOGICAL GENOMICS